2,928 research outputs found
MAVISp_MD_SMPD1_P17405
No full textMD simulations used in MAVISp ensemble mode for SMPD1 in association with a lysosomal-like membrane. Reference: Scrima et al., biorxiv, https://doi.org/10.1101/2023.11.24.56855
MAVISp_MD_SMPD1_P17405
No full textMD simulations used in MAVISp ensemble mode for SMPD1 in association with a lysosomal-like membrane. Reference: Scrima et al., biorxiv, https://doi.org/10.1101/2023.11.24.56855
Rozpor ako východisko, láska ako smer u Simone Weilovej (Contradiction as base, Love as direction in writings of Simone Weil)
No full textArticle is explaining contradiction and love, Simone Weil‘s essential terms of hermeneutics of human Being. It introduces close relation of these terms with her understanding of God as well as with her overall concept of religion. Author also mentions Simone Weil‘s inspirations with philosophical and spiritual concepts of the East
ASM variants in the spotlight:A structure-based atlas for unraveling pathogenic mechanisms in lysosomal acid sphingomyelinase
No full textLysosomal acid sphingomyelinase (ASM), a critical enzyme in lipid metabolism encoded by the SMPD1 gene, plays a crucial role in sphingomyelin hydrolysis in lysosomes. ASM deficiency leads to acid sphingomyelinase deficiency, a rare genetic disorder with diverse clinical manifestations, and the protein can be found mutated in other diseases. We employed a structure-based framework to comprehensively understand the functional implications of ASM variants, integrating pathogenicity predictions with molecular insights derived from a molecular dynamics simulation in a lysosomal membrane environment. Our analysis, encompassing over 400 variants, establishes a structural atlas of missense variants of lysosomal ASM, associating mechanistic indicators with pathogenic potential. Our study highlights variants that influence structural stability or exert local and long-range effects at functional sites. To validate our predictions, we compared them to available experimental data on residual catalytic activity in 135 ASM variants. Notably, our findings also suggest applications of the resulting data for identifying cases suited for enzyme replacement therapy. This comprehensive approach enhances the understanding of ASM variants and provides valuable insights for potential therapeutic interventions.</p
Simulations
No full textCollections of simulations for the publication Maertens JM, Scrima S, Lambrughi M, Genheden S, Trivellin C, Eriksson LA,
Papaleo E, Olsson L, Bettiga M. Molecular-dynamics-simulation-guided membrane engineering allows the increase of membrane fatty acid chain length in Saccharomyces cerevisiae. Sci Rep. 2021 Aug 30;11(1):17333. doi: 10.1038/s41598-021-96757-y. The script and input files can be found in the associated Github repository of our group: https://github.com/ELELAB/YEAST_MEMBRANE_M
Simulations of yeast membranes
No full textCollections of simulations for the publication Maertens JM, Scrima S, Lambrughi M, Genheden S, Trivellin C, Eriksson LA,
Papaleo E, Olsson L, Bettiga M. Molecular-dynamics-simulation-guided membrane engineering allows the increase of membrane fatty acid chain length in Saccharomyces cerevisiae. Sci Rep. 2021 Aug 30;11(1):17333. doi: 10.1038/s41598-021-96757-y. The script and input files can be found in the associated Github repository of our group: https://github.com/ELELAB/YEAST_MEMBRANE_M
Simulations
No full textCollections of simulations for the publication Maertens JM, Scrima S, Lambrughi M, Genheden S, Trivellin C, Eriksson LA,
Papaleo E, Olsson L, Bettiga M. Molecular-dynamics-simulation-guided membrane engineering allows the increase of membrane fatty acid chain length in Saccharomyces cerevisiae. Sci Rep. 2021 Aug 30;11(1):17333. doi: 10.1038/s41598-021-96757-y. The script and input files can be found in the associated Github repository of our group: https://github.com/ELELAB/YEAST_MEMBRANE_M
Simulations
No full textCollections of simulations for the publication Maertens JM, Scrima S, Lambrughi M, Genheden S, Trivellin C, Eriksson LA,
Papaleo E, Olsson L, Bettiga M. Molecular-dynamics-simulation-guided membrane engineering allows the increase of membrane fatty acid chain length in Saccharomyces cerevisiae. Sci Rep. 2021 Aug 30;11(1):17333. doi: 10.1038/s41598-021-96757-y. The script and input files can be found in the associated Github repository of our group: https://github.com/ELELAB/YEAST_MEMBRANE_M
“I beg you to tell me what has become of Djamila”: The Political Mobilization of Simone de Beauvoir’s Readers During the Boupacha Affair
No full textBy Sophia Millman This is a condensed version of a Masters thesis dedicated to the political mobilization of Simone de Beauvoir’s readers. The citations from the letters were translated from French by the author. *** On June 2, 1960, the French government ordered all copies of the daily Algiers edition of Le Monde seized and destroyed to suppress the publication of Simone de Beauvoir’s article “Pour Djamila Boupacha.” Beauvoir, a self-professed “woman of letters”, not “of action[1]”, and one ..
LipidDyn
No full textCollection of simulations used in the publication: " Unraveling membrane properties at the organelle-level with LipidDyn" Scrima S et al., biorxiv, doi: https://doi.org/10.1101/2022.01.04.474788
For the software and other data see also https://github.com/ELELAB/LipidDyn and https://github.com/ELELAB/Lipiddyn_case_studie
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