1,720,968 research outputs found
Design Automation of Lattice-based Customized Orthopedic for Load-bearing Implants
Full text linkThis work aims at the development of a streamlined and robust CAD procedure to design load-bearing implants. The methodology used to reach this result is explained in the paper: 3D digital anatomy reconstruction of defective structures of the patient is performed with the help of a statistical shape model; subsequently, a CAD modelling tool based on implicit modelling (i.e., nTopology) is used to implement a repeatable semi-automatic procedure that can be performed by a competent user with little effort and limited manual operations. Once that the main shape of the implant is defined, lattice geometries are generated to improve mechanical properties of the implant. The procedure requires as inputs the reconstructed anatomy of the patient and a series of clinical indications on the type of implant that needs to be designed. The paper discusses the development of the whole procedure; achieved results, which include the application of the whole framework on multiple case studies, are presented. The procedure allows the design of a whole implant in 20 minutes circa
LIPOSARCOMA MIXOIDE/A CELLULE ROTONDE: RISULTATI CLINICI DI 148 CASI
No full textIntroduzione: lo scopo di questo studio è di valutare i risultati clinici del trattamento multimodale dei pazienti affetti da liposarcoma mixoide/a cellule rotonde (MRCL) e di esaminare i fattori prognostici sul controllo locale e sistemico e sulla sopravvivenza.
Materiali e Metodi: sono stati revisionati i dati clinici e strumentali di 148 pazienti (89 maschi, 59 femmine) trattati nel nostro Centro negli ultimi 25 anni, con un follow-up medio di 73 mesi (min 6, max 257). La localizzazione dei MRCL è stata: arto inferiore in 129 casi (87%), arto superiore in 13 (9%) e tronco in 6 pazienti (4%). L’età media alla diagnosi era di 49 anni (min 16 - max 82). La diagnosi istologica è stata di liposarcoma a basso grado nel 49% dei casi e ad alto grado nel 51%. La dimensione del tumore era inferiore a 5 cm nel 23% dei pazienti, tra 5 e 10 cm nel 45% dei casi e maggiore di 10 cm nel 32% dei casi. Il tumore era alla prima presentazione nel 70% dei casi, mentre nel 18% dei casi si trattava di recidiva locale (RL) e nel restante 12% dei casi era stata eseguita una radicalizzazione di una precedente escissione inadeguata. La sola chirurgia è stata eseguita nel 29% dei casi, mentre sono state associate chemioterapia e/o radioterapia nel 71% dei casi. I margini chirurgici sono risultati radicali nel 1% dei casi, ampi nel 70%, marginali nel 28% e intra-lesionali nel 1%. Dopo l’escissione, in 15 casi è stato usato un lembo di copertura (di rotazione in 4 casi, libero in 11).Risultati: in 15 casi (10%) si è presentata una RL, trattata con escissione in 12 casi e amputazione in 3. Venti pazienti hanno sviluppato metastasi (14%), in un caso già presenti alla diagnosi. Le metastasi erano localizzate ai polmoni in 9 casi ed in sedi extrapolmonari in 11 casi. Al follow-up più recente l’80% dei pazienti era libero da malattia, l’8% era libero da malattia dopo escissione di RL o metastasi, il 2% era vivo con malattia, il 10% era deceduto per la malattia. 11 pazienti (5%) sono stati sottoposti ad amputazione, in un caso come prima procedura chirurgica, in 3 casi dopo RL e in 3 casi per complicazioni dovute alla radioterapia. La sopravvivenza a 5 e 10 anni è stata rispetti-vamente del 90% e 85%. La sopravvivenza libera da RL è stata dell’89% e 86% a 5 e 10 anni e la sopravvivenza libera da meta-stasi è stata del 85% e 81% a 5 e 10 anni. Abbiamo rilevato una differenza statisticamente significativa sia tra margini adeguati e inadeguati e RL (92% vs 82% a 5 anni; 86% vs 82% a 10 anni; P = 0,0457) che nello sviluppo di metastasi (94% vs 63% a 5 anni; 89% vs 63% a 10 anni; P=<0.0001).
Discussione: il trattamento multidisciplinare si è dimostrato efficace nel controllo locale e sistemico del MRCL. I margini chirurgici si sono rivelati l’unico fattore prognostico significativo sia per il controllo locale che sistemico.
Conclusioni: in oltre la metà dei casi le metastasi a distanza erano a localizzazione extra polmonare: questo dovrebbe essere tenuto in considerazione durante il follow-up
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Biological intercalary reconstruction with bone grafts after joint-sparing resection of the lower limb: is this an effective and durable solution for joint preservation?
No full textDue to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts. Inclusion criteria were an osteotomy line within 5 cm from the knee and ankle joint surface and an osteotomy line proximal to 1 cm below the lesser trochanter at the hip level. Intra-epiphyseal resection was performed in 25 patients (39%)and intercalary resection was performed in 39 (61%). Reconstruction included 49 allograft + vascularized fibular graft (VFG), 10 allografts, and 5 VFG + structural allogenic grafts. At a mean follow-up of 117 months (range 12-305), 51 patients (80%) were continuously disease-free, and 6 showed no evidence of disease after treatment of local recurrence or metastatic lesion. One patient was alive with lung metastases at 26 months of follow-up and six patients died of disease. In the entire series of 64 patients, 26 had a non-oncological complication that required surgical revision (40.6%). Overall survival (OS) of reconstruction was 92% at 5 years and 90% at 10 and 15 years. Limb salvage survival (LSS) was 94% at 5, 10 and 15 years. Twenty-two fractures occurred in 17 patients (26.5%). There were a total of nine non-unions (14%). Six patients (9.3%) presented early wound dehiscence (average 1.8 months, range 0-6). A deep infection occurred in 3 cases (4.7 %). In 12 patients treated with VGF reconstruction (12/54:22%), a donor-site complication was observed. The overall Musculoskeletal Tumor Society (MSTS) functional score in 54 evaluable patients, who were alive with reconstruction in situ, was 27 points (range 18-30). Biologic intercalary reconstructions with bone grafts resulted in effective joint-sparing resections of the lower limb, allowing joint preservation in all but one case who required a total knee replacement for varus osteoarthritis. Despite the high rate of complications requiring surgical revision, at 15 years, overall survival of the reconstruction was 90% and limb salvage survival was 94%. In our experience, revision-free survival was better with VFG reconstruction than with allograft alone and the combination of VFG and allogenic graft seems to favor spontaneous fracture-healing and to decrease the non-union rate
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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