117,975 research outputs found

    Cointestazione del conto corrente bancario e morte di uno dei correntisti

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    La cointestazione del conto corrente bancario solleva problematiche di indubbia complessità che risultano ancor più evidenti alla morte di uno degli intestatari del conto. Sul piano della legittimazione a operare sul conto corrente bancario, lo scarno dato normativo di riferimento – costituito dall’art. 1854 c.c. – deve necessariamente coordinarsi con le altre regole che governano la materia; tra esse figura, in particolare, la normativa fiscale, della quale – come opportunamente rimarcato da talune pronunce dell’Arbitro bancario finanziario – non può non tenersi conto. Al contempo, non par dubbio che la generale presunzione di titolarità in parti uguali delle somme giacenti sul conto corrente cointestato – desumibile dall’art. 1854 c.c. – non esclude, nei rapporti interni tra i correntisti, la prova di una situazione giuridica diversa; in tale contesto, si innesta il problema dell’eventuale prova di una donazione indiretta compiuta da un correntista in favore dell’altro, i cui aspetti necessitano di essere ulteriormente indagati

    Suonando suonando. Scola e la musica: il sodalizio con Armando Trovaioli

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    Con venticinque film realizzati nell'arco di quarant'anni, Ettore Scola e Armando Trovaioli (1917-2013), hanno dato vita a una delle più solide, durature ed esclusive collaborazioni nella storia del rapporto tra cinema e musica

    L’attualizzazione del diritto dei contratti: prospettive di semplificazione, chiarezza e intellegibilità della disciplina negoziale in favore dei suoi immediati fruitori

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    Nel contesto odierno, le difficoltà degli schemi contrattuali a essere compresi e attuati dal comune fruitore sono sovente alla base di dissidi e controversie tra i contraenti, con grave nocumento per il regolare svolgimento dei rapporti negoziali. Il contributo indaga la possibilità di semplificare e, ove opportuno, completare la disciplina del contratto e gli schemi contrattuali a disposizione dei suoi fruitori, così come e le tecniche di diffusione e applicazione degli stessi, affinché chiunque possa agevolmente avvalersene. Ciò anche – e a maggior ragione – lì dove il rapporto non sia segnato da una specifica asimmetria contrattuale o non si evidenzino altre esigenze di tutela del contraente debole già prese in considerazione dal legislatore. In questo scenario, tanto il dato comparatistico, quanto talune norme di matrice eurounitaria, offrono un valido terreno per l'indagine

    EVALUATION OF FERRITIN LEVELS AND OTHER CIRCULATING PARAMETERS AS PREDICTIVE BIOMARKERS OF POSTOPERATIVE ATRIAL FIBRILLATION RISK

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    BACKGROUND-AIM Postoperative atrial fibrillation (POAF) represents a critical issue in the cardiovascular area as well as the most common arrhythmia post cardiothoracic surgery. POAF, thus, is associated with diverse severe complications, including potentially fatal conditions. The risk of developing stroke is particularly frequent in post-cardiothoracic surgery AF patients. Little is known about the pathophysiological mechanisms that lead to this fibrillation and there are currently no useful markers to predict it. Yet, it is known that ferritin, a protein that into the serum act as an iron carrier, it’s correlated with an increased risk for atrial fibrillation. METHODS Based on this evidence, here, we evaluated, through a retrospective observational study, the validity of ferritin and other haematological parameters as POAF risk biomarkers in patients undergoing cardiac surgery. The cohort consists of 105 patients (mean age = 70.1 ± 7.1 years; 70 men and 35 females) with an history of cardiothoracic surgery. Haematological, electrocardiographic, and echocardiographic parameters were evaluated. RESULTS The data obtained evidenced that POAF patients showed significantly higher concentrations, absolute values, and percentages, of ferritin, RDW, and PLTs, respectively. However, after adjustment for other risk POAF variables, the ferritin resulted to be the independent factor associated with the onset POAF risk. Such result led us to identify the ferritin cut-off value, which, when equal to or greater than the value of 148.5 ng/mL, identifies the subjects with highest risk of developing POAF. These findings demonstrated, for the first time, the importance of detecting serum ferritin values, and if ≥148.5 ng/mL, the individuals subject to cardiothoracic surgery, this suggests a high probability of developing POAF after the surgery treatment in conventional extracorporeal circulation (CECC). CONCLUSIONS Thus, serum ferritin, RDW, and PTLs represent predictive biomarkers of POAF after cardiothoracic surgery in CECC; particularly, serum ferritin combined with anormal PW indices and structural heart disease variables can represent an excellent tool for predicting not only POAF, but also the eventual stroke onset

    The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming

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    The research on neurodegenerative diseases (NeuroDegD) has been traditionally focused on later life stages. There is now an increasing evidence, that they may be programmed during early development. Here, we propose that NeuroDegD are the result of the complex process of imprinting on fetal hemogenic endothelium, from which the microglial cells make to origin. The central role of placenta and epigenetic mechanisms (methylation of DNA, histone modifications and regulation by non-coding RNAs) in mediating the short and long-term effects has been also described. Precisely, it reports their role in impacting plasticity and memory of microglial cells. In addition, we also underline the necessity of further studies for clearing all mechanisms involved and developing epigenetic methods for identifying potential targets as biomarkers, and for developing preventive measures. Such biomarkers might be used to identify individuals at risk to NeuroDegD. Finally, the sex dependence of fetal programming process has been discussed. It might justify the sex differences in the epidemiologic, imaging, biomarkers, and pathology studies of these pathologies. The discovery of related mechanisms might have important clinical implications in both the etiology of disorders and the management of pregnant women for encouraging healthy long-term outcomes for their children, and future generations. Impending research on the mechanisms related to transgenerational transmission of prenatal stress might consent the development and application of therapies and/or intervention strategies for these disorders in humans

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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