1,720,966 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Systematic Analysis of disease pathways in Congenital, Infantile and Juvenile Neuronal Ceroid Lipofuscinoses
No full textNeuronal ceroid lipofuscinoses (NCL) are common inherited childhood brain disorders. Since 1995, 13 known NCL causative genes (CLN1-8, CLN10-14) have been identified. Despite progress in the NCL field, the primary function and physiological roles of most NCL proteins remain unresolved. In this thesis, we utilized various techniques, such as: functional proteomics, bioinformatics, and mouse disease models, in an effort to clarify disease pathways associated with congenital (CLN10), infantile, late-Infantile (CLN1, CLN5) and juvenile NCL (CLN3) in the human brain.
Firstly, we examined the synaptic proteome in a cathepsin D (Ctsd / Cln10) knockout mouse model of congenital NCL, where the synaptic pathology resembles that of patients. Quantitative mass spectrometry analysis of mouse brain synaptosomes, showed that 43 proteins were differentially expressed in the Ctsd knockout mice brains. We used protein-protein interaction databases to generate a network of differentially expressed proteins and checked individual proteins for involvement in processes, pathways or disease phenotypes. This work highlighted defects in migratory functions of cathepsin D deficient cells that were attributed to downregulation of cytoskeletal proteins.
We also aimed to map the CLN3-CLN5 protein interactome in the brain by identifying their associated proteins. Protein complexes from CLN3 or CLN5 expressing SH-SY5Y stable cells were analysed by mass spectrometry and processed by bioinformatics, to unravel molecular mechanisms underlying CLN3 and CLN5 diseases. Novel CLN3 and CLN5 interacting partners (42 and 31, respectively) were identified in this study. The extent of crosstalk amongst CLN3 and CLN5, suggests that the mechanisms leading to the functional deficits are shared between them. CLN3 was implicated in new roles of G-protein signalling and protein folding / sorting in the ER.
Finally, we analysed protein complexes from human PPT1 (CLN1) expressing SH-SY5Y stable cells as described above. The goal of this study was to identify in vivo PPT1 substrates that could provide insight on the onset and progression of CLN1 disease. Our findings suggest putative new roles of PPT1 in neuronal migration and dopamine receptor mediated signalling pathway.Neuronaaliset seroidilipofuskinoosit (NCL) ovat yleisimpiä lapsuusiässä ilmeneviä periytyviä aivosairauksia. Ensimmäinen NCL:ia aiheuttava geenivirhe julkaistiin jo vuonna 1995 ja sittemmin NCL:ia aiheuttavia alttiusgeenejä on löydetty jo yhteensä 13 (CLN1-8, CLN10-14). Tästä huolimatta useimpien NCL-tauteihin liittyvien geenien ja niiden koodaamien proteiinien ensisijaiset tehtävät soluissa ovat jääneet epäselviksi. Tässä väitöskirjatyössä on tutkittu NCL-tautien kongenitaaliseen (CLN10) sekä lapsuusiän (CLN1), myöhäisen lapsuusiän (CLN5) ja nuoruusiän ilmenemismuotoon johtavia muutoksia solujen toiminnassa hyödyntämällä funktionaalisen proteomiikan ja bioinformatiikan sovelluksia sekä kyseisiin tauteihin kehitettyjä hiirimalleja.
Ensimmäisessä työssä hyödynsimme NCL:in kongenitaaliselle ilmenemismuodolle (CLN10) kehitettyä katepsiini D (Ctsd / Cln10) poistogeenistä hiirimallia, jonka on aikaisemmissa tutkimuksissa todettu ilmentävän hyvin taudin patologisia muutoksia synaptisilla alueilla. Tässä työssä osoitettiin kvantitatiivisen massaspektrometrian avulla, että Ctsd poistogeenisen hiiren aivojen synaptosomaalisella alueella 43 proteiinin ilmenemistasot ovat muuttuneet. Proteiinivuorovaikutustietokantoja hyödyntämällä määritettiin kyseisten proteiinien keskinäinen verkostoituminen sekä tarkistettiin kunkin yksittäisen proteiinin taustat solunsisäisissä prosesseissa, reaktioteissä ja tautifenotyypeissä. Tämän osatyössä ilmeni, että soluilla, joilla katepsiini D proteiinin toiminta on estynyt, on ongelmia solujen liikkumiseen liittyvissä toiminnoissa. Tämän pääteltiin johtuvan solutukirankaproteiinien alentuneesta ilmenemistasosta.
Tämän väitöskirjatyön tavoitteena oli myös kartoittaa CLN3- ja CLN5-proteiinien vuorovaikutusverkostoa aivokudoksessa CLN3- ja CLN5-tautiin johtavien solunsisäisten tapahtumien selvittämiseksi. CLN3- ja CLN5-proteiinia ilmentävien SH-SY5Y-solujen proteiinikompleksit eristettiin ja tunnistettiin massaspektrometrialla, minkä jälkeen tuloksia analysoitiin edelleen bioinformatiikan avulla. Tässä työssä tunnistettiin lukuisia CLN3- ja CLN5-proteiinien vuorovaikutuskumppaneita (42 CLN3-proteiinille ja 31 CLN5-proteiinille). CLN3- ja CLN5-vuorovaikutusverkostojen havaittiin sisältävän keskenään samoja tekijöitä, mikä viittaa siihen, että kyseisiin tauteihin johtavat solunsisäiset molekyylitason muutokset ovat osittain samoja. Tässä työssä selvitettyjen proteiinivuorovaikusverkostojen perusteella CLN3-proteiinilla on aikaisemmin havaitsematon rooli G-proteiinivälitteisessä solunsisäisessä signaloinnissa sekä proteiinien laskostumisessa/solukalvoliikenteen säätelyssä endoplasmaattisessa retikkelissä (ER).
Tämän väitöskirjan viimeisessä osatyössä analysoitiin puolestaan PPT1 (CLN1) -proteiinin vuorovaikutusverkostoja SH-SY5Y-soluissa. Tämän osatyön tavoitteena oli etsiä in vivo substraatteja entsymaattisesti aktiiviselle PPT1-proteiinille, mikä saattaa auttaa CLN1-taudin vaihtelevaan ilmiasuun vaikuttavien tekijöiden selvittämisessä. Tämän osatyön tulosten perusteella PPT1-proteiinilla on ennen, proteiinitasolla havaitsematon rooli hermosolujen liikkumisessa ja dopamiinireseptorivälitteisessä signaalinvälityksessä.ei saavutettav
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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