1,721,131 research outputs found
Interfering with feedback processing: Implications for decision making and learning
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200819.pdf (Publisher’s version ) (Open Access)Radboud University, 30 januari 2019Promotor : Bekkering, H. Co-promotor : Schutter, D.J.L.G.275 p
Haven't I seen you before? Measurement and manipulation of episodic memory confidence
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216190.pdf (Publisher’s version ) (Open Access)Radboud University, 13 maart 2020Promotor : Kessels, R.P.C. Co-promotores : Schutter, D.J.L.G., Hendriks, M.P.H.163 p
The cerebello-hypothalamic-pituitary-adrenal axis dysregulation hypothesis in depressive disorder
No full textItem does not contain fulltextDepressive disorder can be viewed as an adaptive defense mechanism in response to excessive stress that has gone awry. The hypothalamic–pituitary–adrenal (HPA) axis is an important node in the brain’s stress circuit and suggested to play a role in several subtypes of depression. While the hippocampus, amygdala and prefrontal cortex are considered important regions implicated in stress regulation and depressive disorder, the existence of reciprocal monosynaptic cerebello-hypothalamic connections and the presence of dense glucocorticoid binding sites point towards the view that the cerebellum plays a functional role in the regulation of HPA-axis as well. The present hypothesis may further contribute to contemporary neurobiological views on stress regulation and depressive disorder, and may offer a potential biological basis for developing novel neurosomatic treatment protocols
Current directions in the treatment of major depressive disorder
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The Affective Brain : Novel insights into the biological mechanisms of motivation and emotion
Full text linkAffective neuroscience is a new emerging doctrine in the brain sciences, which studies the neurobiological correlates of motivation and emotion. The research reported in this thesis starts with discussing empirical studies on the lateralized involvement of the prefrontal cortex in affective
processing. Next, the involvement of the parietal cortex, the cerebellum and their functional connectivity to the prefrontal cortex in affective processing will be examined. In addition, it will be argued that motivation
and emotion are implemented in multiple and functionally interconnected brain regions. Furthermore, a heuristic working model will be presented, which does not only provide a theoretical basis for testing new hypotheses
in affective neuroscientific research, but also for the clinical application of magnetic brain stimulation in the treatment of depression. The current thesis provides novel insights into the biological mechanisms of affectie
processing, evidenced from electrophysiological, repetitive transcranial magnetic stimulation, endocrinological and behavioral studies
Syncing your brain: Electric currents to enhance cognition
No full textItem does not contain fulltextContemporary studies in cognitive neuroscience demonstrate that cognitive performance can be enhanced by applying exogenous low-intensity electric currents to the brain. These findings have resulted in a widespread interest from both scientists and popular media, particularly, regarding the host of possible applications in everyday life functioning. I discuss here the significance and current challenges of low-intensity electric current stimulation in enhancing cognitive performance.3 p
Electric Current and Emotional Control: Brain stimulation and mental health in military personnel
No full textIt is known that stress and trauma can cause psychological complaints, and that these psychological complaints are accompanied by abnormal activity in certain brain areas. Influencing this brain activity could promote the prevention and treatment of psychological complaints, particularly among military personnel and veterans. For them, current therapies are often insufficiently effective.
Brain activity can be influenced in a safe way with non-invasive brain stimulation. The research in this dissertation focuses on a specific brain stimulation technique called 'tDCS', an abbreviation of transcranial direct current stimulation. Previous research on brain stimulation with tDCS in healthy volunteers shows that tDCS can affect emotional and cognitive processes in a controlled test room environment. This dissertation translated that research into effects on stress-related mental health in military personnel and veterans.
The study results in this dissertation do not provide convincing evidence for positive effects of tDCS on emotional control or recovery from symptoms in military personnel and veterans. That is, we found no relevant effects of the specific way tDCS was applied in two placebo-controlled intervention studies among military personnel and veterans with anxiety, aggression or post-traumatic stress symptoms, and among military personnel without mental health symptoms. Our findings suggest that brain stimulation with tDCS is not yet ready for use in the context of mental health in military personnel and veterans, and underscore the importance of further research into the mechanism of action of tDCS and effective applications
Transcraniële zwakstroomstimulatie voor het verbeteren van cognitie en stemming: Feit of fictie?
No full textWetenschappelijk onderzoek heeft aangetoond dat zwakke elektrische stromen effecten hebben op hersenen en gedrag. Experimentele studies laten zien dat gelijkstroom, dan wel alternerende stroom, cognitieve prestaties van gezonde mensen kunnen verbeteren. Deze effecten zijn echter klein en de praktische toepasbaarheid is nog beperkt. Klinisch onderzoek heeft uitgewezen dat zwakstroomstimulatie op de frontale hersenkwab een positief effect heeft op stemming bij mensen met een depressieve stoornis. Verder onderzoek naar de precieze werkingsmechanismen is nodig voor het vaststellen van de reikwijdte van deze techniek als het gaat om gedragsbeïnvloeding
Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis - Corrigendum
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129963.pdf (Publisher’s version ) (Open Access)1 p
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