1,720,953 research outputs found
Diagnosis of Myocardial Diseases Applying Cardiac Magnetic Resonence
No full textHabilitationsschriftIn der Kardiologie stellt die nichtinvasive Differenzierung von Myokardschäden
noch immer eine diagnostische Herausforderung dar. In dieser Arbeit wurde die
kardiale Magnetresonanztomographie genutzt, um Myokardschäden zu
differenzieren und Zusammenhänge zu funktionellen Veränderungen, insbesondere
bei primären und sekundären Kardiomyopathien zu untersuchen. Es ist gelungen,
Einsatzmöglichkeiten der Methode aufzuzeigen, die bereits auch Verbreitung in
der klinischen Routine gefunden haben. Bei der Hypertrophischen
Kardiomyopathie führten wir die Planimetrie der Fläche des linksventrikulären
Ausflusstraktes zur Quantifizierung der Obstruktion ein und konnten nicht nur
Patienten nach Septumablation kontrollieren, sondern erstellten auch Normwerte
zur Differenzierung der Obstruktion. Nach der Intervention wurden im
zeitlichen Verlauf die Evolution des peri-infarziellen Ödemes und der
Infarktnarbe, einschließlich des Zusammenhanges zur funktionellen und
klinischen Verbesserung untersucht. Durch die Anwendung einer Kombination von
T2-gewichteten und kontrastverstärkten T1-gewichteten Sequenzen im zeitlichen
Verlauf konnten sowohl die sehr frühen als auch die späten
Myokardveränderungen dargestellt werden. Da die therapeutisch indizierte
Intervention ohne Induktion einer alkoholbedingten Kolliquationsnekrose mit
Schaumstoffpartikeln durchführt wurde, ist das Ergebnis mit einer nicht
iatrogenen akuten Koronararterienokklusion vergleichbar. Dies erlaubt
Rückschlüsse auf die Darstellung eines akuten Infarkt mittels
Magnetresonanztomographie. Der echokardiographische Nachweis von
Wandbewegungsstörungen ist eine grundlegende diagnostische Information,
allerdings ist die Unterscheidung zwischen einer entzündlichen oder
ischämischen Genese nicht möglich. Diese Lücke kann nunmehr durch die kardiale
Magnetresonanztomographie geschlossen werden. Das von uns eingeführte
multisequentielle Protokoll führte zum Beispiel bei der Myokarditis zu einer
Verbesserung der diagnostischen Genauigkeit der magnetresonanztomographischen
Untersuchungen. Ebenso konnte eine myokardiale Mitbeteiligung bei Sarkoidose
bereits bei normaler linksventrikulärer Funktion gezeigt werden. Für die
Darstellung der Koronararterien wurde eine 3D-Steady-State-Free-Precession-
Sequenz bei gesunden Probanden und in klinischer Umgebung geprüft, sie erwies
sich als verlässlich, muss aber noch weiter evaluiert werden. Die kardiale MRT
hat in einigen kardiologischen Bereichen bereits Eingang in die Routine
gefunden. Die Methode hat das Potenzial, prospektiv reversible und
irreversible myokardiale Veränderungen zu unterscheiden und sie darüber hinaus
im Verlauf zu untersuchen. Es ist zu erwarten, dass auf dem Gebiet der
myokardialen Erkrankungen nichtinvasive bildgebende Differenzierungen zur
Charakterisierung des klinischen Status und Therapieerfolges beitragen werden.
Weitere Studien werden gestatten, die prognostische Relevanz frühzeitig
erfasster Veränderungen zur bewerten.Non-invasive differentiation of myocardial injury is an ongoing diagnostic
challenge in cardiology. We used cardiac magnetic resonance to characterize
myocardial injuries and to investigate their relations to functional changes,
especially in primary and secondary cardiomyopathies. We were able to describe
novel applications of CMR, which are currently used in routine settings. The
planimetry of the left ventricular outflow tract area to quantify obstruction
was developed to characterize hypertrophic cardiomyopathies (HCM). We applied
the method in patients after septal artery embolization to monitor the success
of the intervention. We then extended our observations to establish cut-off
values to differentiate between the obstructive and non-obstructive forms of
HCM and to provide the first reference standard for planimetric values in
healthy volunteers. After intervention infarct related edema and fibrosis was
detected during follow-up and correlated to functional and clinical
improvement of the patients. Combining of T2-weighted and contrast-enhanced
T1-weighted images allowed the detection of very early and late myocardial
changes during follow-up. As the intervention was performed using foam gel
instead of alcohol, the therapeutically induced infarction was similar to an
abrupt coronary occlusion in the clinical setting in contrast to the non-
physiological alcohol-like colliquation-necrosis. As such, we were able not
only to monitor the intervention-related tissue injuries but also to gain
novel insights into the very early myocardial tissue injuries in acute
myocardial infarction Assessment of wall motion abnormalities applying
echocardiography is a basic diagnostic information, but it is not possible to
differentiate between e.g. inflammatory or ischemic aetiologies. Applying
cardiac magnetic resonance (CMR), this information can be provided. Exploiting
the unique tissue characterization capabilities of CMR, we introduced a multi-
sequential approach, which was shown to increase the diagnostic accuracy of
magnetic resonance imaging to detect myocarditis. Applying a similar approach
we were able to detect myocardial involvement in sarcoidosis even when left
ventricular function was still preserved. A 3D-steady-state-free-precession
pulse sequence was applied in volunteers and patients and could be shown to be
applicable, but has to be improved. Cardiac magnetic resonance is routinely
applied in many areas of cardiology. The method has the potential to
differentiate prospectively between reversible and irreversible myocardial
injuries. The changes can be detected during follow-up. One could expect, that
in the field of myocardial diseases the differentiation by non-invasive
imaging modalities will improve clinical characterization and monitor the
success of therapy or (therapeutic success). Further studies will allow
identifying the prognostic values of the early-detected injuries
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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