729 research outputs found
Unpacking the Ambiguous Case to Develop Conceptual Knowledge and Representational Competence
No full textThe ambiguous case is a trigonometry topic for which high school students are often told “stay away from angle-side-side.” In many cases, however, these students do not get the opportunity to explore the underlying mathematical context that serves as the basis of this warning. After a briefly presenting an overview of the ambiguous case, the author describes a mathematical activity using simple homemade manipulatives to support secondary and post-secondary students’ work to unpack and understand the ambiguous case. It then discusses how this activity can support teachers’ understanding of representational competence and recommends general practices supporting students\u27 purposeful and effective use of mathematical representations
Indigenous Detroit: indigeneity, modernity, and racial and gender formation in a modern American city, 1871-2000
No full textThis dissertation traces the role of indigeneity in the formation of modern Detroit and the impact of urban culture on the reemergence of Indigenous people in that same location at the end of the 20th century. Covering more than a hundred years of urban Indigenous history between the nexus of urban history and Indigenous studies, Indigenous Detroit examines, first, non-Natives elites, and later, Native people, and how both deployed gendered and racialized versions of indigeneity. In both instances, “indigenous” identities carried racial and gendered meanings that helped to animate their appeal. Using local newspapers, government documents, and oral histories, this dissertation demonstrates how non-Indians used images of indigeneity to erase Native people from Detroit’s history. Indigenous people reasserted their presence in the Motor City, challenging longstanding definitions of indigeneity. In the first two chapters, I argue that, in a quest to bolster both white masculinity and Detroit’s urban standing, elite white men both memorialized and erased Detroit’s indigenous past. However, as I argue in chapters three and four, Indigenus residents such as Dakota Charles Eastman and women like my great-grandmother Esther Shawboose Mays carved out spaces in Detroit to reinvigorate and redefine indigeneity through the creation of Indigenous cultural and educational institutions in a city now predicated on blackness, whiteness, and labor.Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-05-01The student, Kyle Mays, accepted the attached license on 2015-04-22 at 12:01.The student, Kyle Mays, submitted this Dissertation for approval on 2015-04-22 at 12:08.This Dissertation was approved for publication on 2015-04-22 at 15:30.DSpace SAF Submission Ingestion Package generated from Vireo submission #8020 on 2015-07-22 at 14:18:32Made available in DSpace on 2015-07-22T22:33:46Z (GMT). No. of bitstreams: 2
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Previous issue date: 2015-04-22Embargo set by: Seth Robbins for item 79894
Lift date: 2017-07-22T22:34:16Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 79894 on 2017-07-23T09:15:17Z
Review of The Burke Collection of Italian Manuscript Paintings. Sandra Hindman and Federica Toniolo, eds. London: Paul Holberton Publishing, 2021. 472 pp. £80.
No full textThe Burke Collection, assembled over the last two decades by T. Robert Burke and Katherine States Burke, is on deposit in Special Collections at the Stanford Libraries of Stanford University. Open to researchers and students, it comprises works produced in Italy from the twelfth to sixteenth centuries, predominantly manuscript paintings and leaves from choir books (antiphonals and graduals that contain the music for the divine offices and the mass, respectively) and their liturgical counterparts (breviaries and missals). Sandra Hindman and Federica Toniolo bring together essays on the collection's forty-two illuminations and two complete manuscripts into a beautiful catalogue, introduced by Christopher de Hamel and organized by chronology and geographic region. Seventeen prominent scholars from North America and Europe contribute artist biographies and individual catalogue entries. While thirty-five artists from six regions of Italy are represented (Umbria, Tuscany, Emilia Romagna, Lombardy, Veneto, and Lazio), the clear strength in the Burke Collection lies in works produced in Florence and Siena during the fourteenth and fifteenth centuries.This review is published as :Kyle SR. The Burke Collection of Italian Manuscript Paintings. Sandra Hindman and Federica Toniolo, eds. London: Paul Holberton Publishing, 2021. 472 pp. £80. Renaissance Quarterly. 2022;75(4):1368-1370. doi:10.1017/rqx.2022.374. Posted with permission.Copyright © The Author(s), 2022
Lithic technological responses to Late Pleistocene glacial cycling at Pinnacle Point Site 5-6, South Africa
No full textabstract: There are multiple hypotheses for human responses to glacial cycling in the Late Pleistocene, including changes in population size, interconnectedness, and mobility. Lithic technological analysis informs us of human responses to environmental change because lithic assemblage characteristics are a reflection of raw material transport, reduction, and discard behaviors that depend on hunter-gatherer social and economic decisions. Pinnacle Point Site 5–6 (PP5-6), Western Cape, South Africa is an ideal locality for examining the influence of glacial cycling on early modern human behaviors because it preserves a long sequence spanning marine isotope stages (MIS) 5, 4, and 3 and is associated with robust records of paleoenvironmental change. The analysis presented here addresses the question, what, if any, lithic assemblage traits at PP5-6 represent changing behavioral responses to the MIS 5-4-3 interglacial-glacial cycle? It statistically evaluates changes in 93 traits with no a priori assumptions about which traits may significantly associate with MIS. In contrast to other studies that claim that there is little relationship between broad-scale patterns of climate change and lithic technology, we identified the following characteristics that are associated with MIS 4: increased use of quartz, increased evidence for outcrop sources of quartzite and silcrete, increased evidence for earlier stages of reduction in silcrete, evidence for increased flaking efficiency in all raw material types, and changes in tool types and function for silcrete. Based on these results, we suggest that foragers responded to MIS 4 glacial environmental conditions at PP5-6 with increased population or group sizes, ‘place provisioning’, longer and/or more intense site occupations, and decreased residential mobility. Several other traits, including silcrete frequency, do not exhibit an association with MIS. Backed pieces, once they appear in the PP5-6 record during MIS 4, persist through MIS 3. Changing paleoenvironments explain some, but not all temporal technological variability at PP5-6.The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.017405
Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
No full textThis article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above recent studies their combinatorial targeting may be justified in the development of future treatments. In order to investigate effects of BRCA2 that can be explored for this combinatorial targeting we focused on the analysis of recombination rates at telomeres by monitoring T-SCEs (Telomere Sister Chromatid Exchanges). Results: We observed a significant increase in T-SCE frequencies in four BRCA2 defective human cell lines thus suggesting that BRCA2 suppresses recombination at telomeres. To test this hypothesis further we analyzed T-SCE frequencies in a set of Chinese hamster cell lines with or without functional BRCA2. Our results indicate that introduction of functional BRCA2 normalizes frequencies of T-SCEs thus supporting the notion that BRCA2 suppresses recombination at telomeres. Given that ALT (Alternative Lengthening of Telomeres) positive cells maintain telomeres by recombination we investigated the effect of BRCA2 depletion in these cells. Our results show that this depletion causes a dramatic reduction in T-SCE frequencies in ALT positive cells, but not in non-ALT cells. Conclusion: BRCA2 suppresses recombination at telomeres in cells that maintain them by conventional mechanisms. Furthermore, BRCA2 depletion in ALT positive cells reduces high levels of T-SCEs normally found in these cells. Our results could be potentially important for refining telomerase-based anti-cancer therapies.This work is supported in part by grants from European Commission RISC-RAD contract FI6RCT2003-508842 and British Counci
A soldier of the legion lay dying in Algiers,
No full textvoiceContinued by Binghin on the Rhine (cont.)Collected by Merlin Mitchell
Transcribed by Kyle Perrin
Mrs. Bement
Springdale, Ark.
April 19, 1950
Binghin on the Rhine
A soldier of the legion lay dying in Algiers,
There was lack of woman's nursing, derth of woman's tears,
A comrad stood beside him as Ma life-blood ebbed away,
AND death with fleeing glances to hear what he might say.
The dying soldier faultered as he took that comrad's hint,
And said, I never more shall see my own, my native land,
Take a message and a token to some distant friends of nine,
For I was born at Binghin, at Binghin on the Rhine.
Tell my brothers and companions when they meet and crowd around
To them I . . . mournful stories(?) in the pleasant vinyard brown(?),
That we fought the battle bravely and when the day was done,
Full many a-corpse lay ghastly pale beneath the setting sun.
Amidst the dead and dying were some grown old in wars,
Who . . . the last of many scars,
But some were young and suddenly beheld l i f e ' s morn decline,
And wounded come from Binghin, from Binghin on the Rhine.
Tell my mother that her other sons shall comfort her old age,
And I was a trooper that thought his home a cage,
For my father was a soldier and even as a child,
My heart leaped for to hear him tell of struggles fierce and wild.
And when he died and l e f t us to divide his scanty hoard,
I let them take whate'er they would but kept my father's sword,
And my boyish . . . the bright light use to shine,
On the cottage at fair Binghin, fair Binghin on the Rhine.
Tell my sister not to weep o'er me and sob with drooping head,
When the troops are marching home again with glad and galant tread,
But to look upon them proudly with a calm, steadfast eye,
or her brother was a soldier, too, and not afraid to die.
And i f a comrad seek her love, why ask her my name,
To lock upon him proudly without regret or shame,
And to hang the old SWORD in its place, my father's sword and mine,
Far down(?) in old Binghin, dear Binghin on the Rhine.
There's another, rot a sister, in happy days gone by,
You're to know her by the . . . that sparkled in her eye,
Who the simple coquetry to f a l l for bridal scorning,
Oh, friends, I fear the lightest heart makes sometimes heaviest mourning.
**The next three verses are also found on reel 40.
***The remainder of the song is found on reel 40.
Reel 39
Item (more)
Binghin on the Rhine (Cont.)
Tell her the last night of my l i f e 'fore e'er the noon be risen,
My body will be out of pain, my soul be out of prison,
I dreamed I stood with her and saw the yellow sunlight shine,
On the fine paths(?) of Binghin, f a i r Binghin on the Rhine.
I saw the blue Rhine sweep a l o n g ( ? ) , I heard or seemed to hear,
The Germans all they use to sing in chorus sweet and clear,
And on the plaza clean(?) and up the slanting h i l l,
The echoing chorus sounded through the evening calm and s t i l l .
And her glad blue eyes were on me as we passed with friendly talk,
The many a-path belong to yore and well remembered walk,
And her l i t t l e hand lay lightly, invitingly in mine,
I looked no more at Binghin, at Binghin on the Rhine.
His voice grew faint and courser, his grasp was childish weak,
His eyes put on a dying look, he sighed but ceased to speak,
A comrad bent to l i f t him but the spark of l i f e had fled,
The soldier of the ligion in a foreign land was dead.
And the soft moon rose up slowly and coldly she looked down,
On the wreched and bloody(?) battlefield with bloody corpses strewn,
Yea, come she on that dreadful scene, her pale light seemed to shine,
As she shown can distant Binghin, f a i r Binghin on the Rhine.
Mitch..Who's the author of that song?
Mrs.B..A Mistress Norton. It's in such fine print—Mistress Norton,
Caroline Elizabeth Sheridan was granddaughter of Richard Greenly
Sheridan—
Mitch..Is the date of the song given?
Mrs. B..No, but the Germans have been fighters all these years, you know.
This is printed in I860. I don't know how Iong this happened
before that, Well, one, I suppose, Just composed i t . If you
could read it—if you want to read that latter part there—
I t ' s in such fine print that I can't read i t.Funding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
Supporting mathematics teacher educators’ practices for facilitating prospective teachers’ mathematical explanations in content courses
No full textThe push for more student-generated explanations in K-8 mathematics classrooms, together with prospective teachers’ well-documented weaknesses in both providing adequate explanation and appreciating what constitutes a sound mathematical explanation, points to the need for more experiences for prospective teachers to formulate explanations of mathematical ideas before asking them to facilitate students’ explanations. Creating experiences for prospective teachers to wrestle with challenging mathematics and learn to elicit, develop, and evaluate mathematical explanations is a responsibility of mathematics teacher educators (MTEs) who teach content courses for teachers. Our work considers MTEs’ practices that encourage prospective elementary teachers to construct and critique explanations. Through examination of data from a professional development designed for MTEs, we identified what aspects of prospective elementary teachers’ mathematical explanations MTEs attended to while observing and discussing a math content course for prospective elementary teachers. From this study we identified five MTE practices that provide opportunities to engage PSTs in constructing mathematical explanations. Specific strategies for MTEs to implement these practices are shared and related dilemmas are discussed
Binghin on the Rhine
No full textCollected by Merlin Mitchell
Transcribed by Kyle Perrin
Mrs. Bement
Springdale, Ark.
April 19, 1950
Binghin on the Rhine
A soldier of the legion lay dying in Algiers,
There was lack of woman's nursing, derth of woman's tears,
A comrad stood beside him as Ma life-blood ebbed away,
AND death with fleeing glances to hear what he might say.
The dying soldier faultered as he took that comrad's hint,
And said, I never more shall see my own, my native land,
Take a message and a token to some distant friends of nine,
For I was born at Binghin, at Binghin on the Rhine.
Tell my brothers and companions when they meet and crowd around
To them I . . . mournful stories(?) in the pleasant vinyard brown(?),
That we fought the battle bravely and when the day was done,
Full many a-corpse lay ghastly pale beneath the setting sun.
Amidst the dead and dying were some grown old in wars,
Who . . . the last of many scars,
But some were young and suddenly beheld l i f e ' s morn decline,
And wounded come from Binghin, from Binghin on the Rhine.
Tell my mother that her other sons shall comfort her old age,
And I was a trooper that thought his home a cage,
For my father was a soldier and even as a child,
My heart leaped for to hear him tell of struggles fierce and wild.
And when he died and l e f t us to divide his scanty hoard,
I let them take whate'er they would but kept my father's sword,
And my boyish . . . the bright light use to shine,
On the cottage at fair Binghin, fair Binghin on the Rhine.
Tell my sister not to weep o'er me and sob with drooping head,
When the troops are marching home again with glad and galant tread,
But to look upon them proudly with a calm, steadfast eye,
or her brother was a soldier, too, and not afraid to die.
And i f a comrad seek her love, why ask her my name,
To lock upon him proudly without regret or shame,
And to hang the old SWORD in its place, my father's sword and mine,
Far down(?) in old Binghin, dear Binghin on the Rhine.
There's another, rot a sister, in happy days gone by,
You're to know her by the . . . that sparkled in her eye,
Who the simple coquetry to f a l l for bridal scorning,
Oh, friends, I fear the lightest heart makes sometimes heaviest mourning.
**The next three verses are also found on reel 40.
***The remainder of the song is found on reel 40.
Reel 39
Item (more)
Binghin on the Rhine (Cont.)
Tell her the last night of my l i f e 'fore e'er the noon be risen,
My body will be out of pain, my soul be out of prison,
I dreamed I stood with her and saw the yellow sunlight shine,
On the fine paths(?) of Binghin, f a i r Binghin on the Rhine.
I saw the blue Rhine sweep a l o n g ( ? ) , I heard or seemed to hear,
The Germans all they use to sing in chorus sweet and clear,
And on the plaza clean(?) and up the slanting h i l l,
The echoing chorus sounded through the evening calm and s t i l l .
And her glad blue eyes were on me as we passed with friendly talk,
The many a-path belong to yore and well remembered walk,
And her l i t t l e hand lay lightly, invitingly in mine,
I looked no more at Binghin, at Binghin on the Rhine.
His voice grew faint and courser, his grasp was childish weak,
His eyes put on a dying look, he sighed but ceased to speak,
A comrad bent to l i f t him but the spark of l i f e had fled,
The soldier of the ligion in a foreign land was dead.
And the soft moon rose up slowly and coldly she looked down,
On the wreched and bloody(?) battlefield with bloody corpses strewn,
Yea, come she on that dreadful scene, her pale light seemed to shine,
As she shown can distant Binghin, f a i r Binghin on the Rhine.
Mitch..Who's the author of that song?
Mrs.B..A Mistress Norton. It's in such fine print—Mistress Norton,
Caroline Elizabeth Sheridan was granddaughter of Richard Greenly
Sheridan—
Mitch..Is the date of the song given?
Mrs. B..No, but the Germans have been fighters all these years, you know.
This is printed in I860. I don't know how Iong this happened
before that, Well, one, I suppose, Just composed i t . If you
could read it—if you want to read that latter part there—
I t ' s in such fine print that I can't read i t.Funding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2
No full textWhile much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxylate substrate proline residues and have been linked to fuel switching. Here, we reveal that PHD3 rapidly triggers repression of FAO in response to nutrient abundance via hydroxylation of acetyl-coA carboxylase 2 (ACC2). We find that PHD3 expression is strongly decreased in subsets of cancer including acute myeloid leukemia (AML) and is linked to a reliance on fat catabolism regardless of external nutrient cues. Overexpressing PHD3 limits FAO via regulation of ACC2 and consequently impedes leukemia cell proliferation. Thus, loss of PHD3 enables greater utilization of fatty acids but may also serve as a metabolic and therapeutic liability by indicating cancer cell susceptibility to FAO inhibition
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