21,177 research outputs found
Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors
No full textThe microbial macrolides bafilomycin A(1), B-1, and concanamycin A from Streptomyces spp. are potent and specific inhibitors of V-ATPases. The question of the biosynthetic origin of the two uncommon "glycolate units" of each of the macrolide structures was addressed by feeding experiments with stereo specifically C-13-labeled precursors. Our studies clearly indicate that glycerol is a source for the methoxylated C-2-units and determines the orientation of the incorporation. Products from the carboxylic acid pool or TCA cycle are ruled out as key precursors. The data suggest the action of a glycerol kinase and point to phosphoglycerate as an intermediate in their biosynthesis. However, glycerate itself is not accepted as a precursor. We present the likely biosynthetic pathway and show the value of stereospecifically labeled presursors as an important tool for biosynthetic investigations.NIBIB NIH HHS [EB002166
Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors
No full textThe microbial macrolides bafilomycin A(1), B-1, and concanamycin A from Streptomyces spp. are potent and specific inhibitors of V-ATPases. The question of the biosynthetic origin of the two uncommon "glycolate units" of each of the macrolide structures was addressed by feeding experiments with stereo specifically C-13-labeled precursors. Our studies clearly indicate that glycerol is a source for the methoxylated C-2-units and determines the orientation of the incorporation. Products from the carboxylic acid pool or TCA cycle are ruled out as key precursors. The data suggest the action of a glycerol kinase and point to phosphoglycerate as an intermediate in their biosynthesis. However, glycerate itself is not accepted as a precursor. We present the likely biosynthetic pathway and show the value of stereospecifically labeled presursors as an important tool for biosynthetic investigations.NIBIB NIH HHS [EB002166
Report on Meteorological Research March 1, 1935 (m-1)
No full textThe object of the report was to elucidate in detail the various features of the research program in meteorology being carried on at the Daniel Guggenheim Airship Institute in Akron, Ohio. Mr. L. J. Fangman, of the U.S. Weather Bureau, was collaborating with the author in carrying out work such as a study of autographic records of the various meteorological elements during frontal passages with a view to the possible prediction of the intensity of the accompanying disturbance as it may affect the operation of aircraft and a study of atmospheric gustiness with a view to finding the dependence between frequency end amplitude of velocity fluctuations and the vertical temperature and velocity gradients
ElKowmGIS : ein neues System zur Dokumentation archäologischer Fundstellen
No full textSeit dem Jahr 2005 beruht die Dokumentation der paläolithischen Grabung Hummal (El Kowm, Syrien) auf der Dokumentation mittels Computer. Hierfür wurde, speziell für die Vermessung, die Software AutoCAD mit den Applikationen TachyCAD und Photoplan angeschafft. Hierbei handelt es sich um eine kommerzielle Lösung, welche in vielen archäologischen Institutionen zum Einsatz kommt. Während der Arbeit mit diesem System fiel jedoch auf, dass nicht alle Belange, welche ein Archäologe haben kann, berücksichtigt werden (können). Eine Anpassung der Software auf die individuelle Grabung ist nicht ohne weiteres möglich, da es sich hierbei um Lösungen handelt, die nicht frei veränderbar sind. Aus der Notwendigkeit, eine anpassbare Lösung zu haben, entstand die Idee, eine eigene Softwarelösung zu produzieren, welche von Archäologen für Archäologen geschaffen wurde. Hierbei handelt es sich um ElKowmGIS, einem archäologischen Dokumentationssystem, welches im Wesentlichen die drei Bestandteile CAD, GIS und Datenbank in einem Paket vereint. Für die Entwicklung von ElKowmGIS wurden im Rahmen einer Doktorarbeit folgende Grundregeln definiert:
- Plattformunabhängigkeit: Der User soll die Software auf “seinem“ Computer nutzen können, egal welches Betriebssystem installiert ist.
- Modularer Aufbau: Das System soll so aufgebaut sein, dass für jede Aufgabenstellung Module zur Verfügung gestellt werden. Fehlt ein Modul, so kann es ohne weiteres nachträglich erstellt werden.
- Adaption der Software: Die Software soll auf die Dokumentationsstruktur anpassbar sein, nicht umgekehrt.
- “Künstliche Intelligenz“: Das Programm soll gewisse Aufgaben, z.B. Weiterführung der Laufnummer, Sortieren der Bilder, etc., selbstständig ausführen. Der Benutzer muss lediglich die Regeln hierfür vorgeben.
- Dokumentstruktur und Dateigrößen: Die verwendete Datenbank im Hintergrund soll es ermöglichen, mit kleinstmöglichem Platzbedarf und Zeitaufwand die erhobenen Daten zu sichern und auch zu verwenden.
- Anwenderfreundlichkeit: Das Programm soll selbsterklärend sein, d.h. der User soll sich alleine zurechtfinden, ohne tagelang ein Handbuch wälzen zu müssen.
Für die Implementierung wurde die Kombination aus JAVA, für die Programmierung der Benutzeroberfläche, und PostgreSQL als Datenbankserver gewählt. Zum einen bietet sich hier die Möglichkeit, die Plattformunabhängigkeit zu implementieren. Zum anderen lässt sich dadurch das ganze System modular aufbauen
(Fourth) Report on Meteorological Activities at the DGAI (8-1-36)(Weather Bureau Copy)
No full textThis report is on the investigations of frontal phenomena at the Daniel Guggenheim Airship Institute in Akron, Ohio from January 1, 1935 through August 1, 1936. The investigation was carried out with the cooperation of the U.S. Bureau of Aeronautics, the U.S. Weather Bureau, the California Institute of Technology, and the Guggenheim Airship Institute. Mr. R.C. Robinson of the Weather Bureau cooperated with the author in carrying out the investigation. The object of the investigation was to determine the intensity of the atmospheric disturbances (i.e. rapidity of wind shift and gustiness) accompanying the passage of cold fronts, along with a study of the characteristics of the air masses involved and other features which might affect the intensity of the disturbance. The report treated thirty cold fronts which passed the station during 1935 to 1936
Archives and Images as Repositories of Time, Language, and Forms from the Past: A Conversation with Daniel Eisenberg
No full textDaniel Akech
No full textabstract: Daniel was a little boy when the war came to his village. He witnessed people being shot and running for shelter. There was no food or water so he drank urine and ate tree leaves.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 24Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel Emmett postcard
No full textPostcard of Daniel Emmett and his home in Mount Vernon, Ohio. Emmett is considered to be the author of the antebellum song "Dixie," written in 1859, which became the unofficial song of the Confederate soldiers during the American Civil War. He was born in Mount Vernon in 1815 and taught himself the fiddle, and later became associated with minstrel shows and helped to define that genre. Minstrel shows traveled around the United States, presenting skits and musical performances. Emmett also composed many other songs, including "Old Dan Tucker," "Turkey in the Straw," and "The Blue Tail Fly." He died in 1904
Daniel Jau Maper
No full textabstract: Daniel Jau Maper was herding cattle when Arabs attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 27Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel A. Ngor
No full textWhen Daniel was five years old Arab soldiers attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age : 23Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
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