1,720,977 research outputs found
E2A expression stimulates Ig hypermutation
No full textIg hypermutation is limited to a region of 2 kb downstream of the transcription start sites of the Ig loci. The process requires
transcription and the presence of Ig enhancer sequences, and is initiated by the activation-induced cytidine deaminase (AID)-
mediated deamination of cytidine bases. It remains unknown why AID causes mutations selectively in the Ig genes and not in most
other transcribed loci of B cells. In this study, we report that the inactivation of the E2A gene strongly reduces the rate of Ig L
chain mutations in the chicken B cell line DT40 without affecting the levels of surface Ig or AID expression. The defect is
complemented by the expression of cDNAs corresponding to either of the two E2A splice variants E12 or E47. The results suggest
that E2A-encoded proteins enhance Ig hypermutation by recruitment of AID to the Ig loci
E. Douglas van Buren — I. Foundation figurines and offerings. 1931 — II. The flowing vase and the god with streams. 1933. Berlin, Hans Schoetz u. C°, Verlagsbuechh. (Walter de Gruyter u. C°.)
No full textRonzevalle Sébastien. E. Douglas van Buren — I. Foundation figurines and offerings. 1931 — II. The flowing vase and the god with streams. 1933. Berlin, Hans Schoetz u. C°, Verlagsbuechh. (Walter de Gruyter u. C°.). In: Mélanges de l'Université Saint-Joseph, tome 17, 1933. pp. 197-198
Inherent radioresistance of head and neck squamous cell carcinoma cells: principal component analysis identifies cellular senescence as a crucial driver
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Inherent radioresistance of head and neck squamous cell carcinoma cells: principal component analysis identifies cellular senescence as a crucial driver
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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