117,155 research outputs found

    Fibrous Cap Thickness and Smooth Muscle Cell Apoptosis in High-grade Carotid Artery Stenosis

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    AbstractObjectiveThere is growing evidence that, in high-grade internal carotid artery (ICA) stenosis, continuous fibrous cap thinning is not mandatory for plaque rupture and symptom development. The possibility that smooth muscle cell (SMC) apoptosis is involved in loss of fibrous cap volume has only been examined in a limited number of patients with high grade carotid artery stenosis.MethodsEndarterectomy specimens from n=38 consecutive patients undergoing surgery for high-grade ICA stenosis (≥70%) were transversely sectioned at 2mm intervals. Plaque instability was defined clinically, by a history of recent ischemic symptoms (<60 days before surgery; n=19) attributable to the stenosis, or histopathologically by the presence of plaque rupture (n=14). Detailed morphometric analyses of the fibrous cap was based on routine stains; for DNA in situ end labeling the TUNEL technique was used. SMCs were identified by immunostaining for SMC actin.ResultsWe found no significant difference between symptomatic/asymptomatic or ruptured/unruptured plaque with respect to various morphometric measures of the fibrous cap (i.e. mean area, number of plaque sections with fibrous cap, necrotic core-to-lumen distance at its thinnest or thickest part). The mean (±SD) apoptotic SMCs per thousand within the fibrous cap was significantly higher in symptomatic vs. asymptomatic (64.53±77.3 vs. 6.71±11.9; P<0.001) but not in ruptured plaques (43.3±64.4 vs. 30.1±60.9; P=0.117).ConclusionsThese data suggest that continuous thinning of the fibrous cap is not an essential prerequisite for plaque rupture in ICA stenosis. Symptomatic, but not ruptured plaque, were associated with the highest number of apoptotic SMC. Thus, it seems unlikely that SMC apoptosis promotes plaque rupture by fibrous cap thinning

    Workload-Ahead-Driven Online Energy Minimization Techniques for Battery-Powered Embedded Systems with Time-Constraints

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    This paper proposes a new online voltage scaling (VS) technique for battery-powered embedded systems with real-time constraints. The VS technique takes into account the tasks execution times and discharge currents to further reduce the battery charge consumption when compared to the recently reported slack forwarding technique, whilst maintaining low online complexity of O(1). Furthermore, we investigate the impact of online rescheduling and remapping on the battery charge consumption for tasks with data dependency which has not been explicitly addressed in the literature and propose a novel rescheduling/remapping technique. We demonstrate and compare the efficiency of the presented techniques using seven real-life benchmarks and numerous automatically generated examples

    Predatory Cooperation: Reaction to L. Ahrens, L. Hakelberg & T. Rixen

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    In \u27Breaking the shackles of tax competition: How financial transparency enables governments to tax portfolio capital\u27, Ahrens, Hakelberg, and Rixen note that after decades of decline in the capacity of OECD member countries to tax, those rich countries seem finally to have recovered the knack. To date, they have only applied that newfound knowledge to taxing individuals. The authors optimistically conclude that since international cooperation allowed OECD states to gain the upper hand in their fight against tax evasion by individuals, international cooperation could do the same for tax avoidance by corporations

    Low Power Process Assignment for Distributed Embedded Systems using Dynamic Voltage Scaling

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    This paper presents an efficient algorithm for voltage scaling of an distributed embedded system taking communicating processes into account. The algorithm finds scaled voltages for each processes without restricting the applicable voltage levels apriori. In addition the algorithm is not limited by a fixed power consumption among processes. Furthermore we show the importance of a process optimisation which is optimised for the dynamic voltage scaling (DVS) technique. Various examples from the literature and randomly generate show the efficiency of the proposed scaling algorithm and the DVS optimised process assignment

    T. Spidlik, L'idée russe. Une autre vision de l'homme, 1994

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    Schmitz-Perrin Rudolf. T. Spidlik, L'idée russe. Une autre vision de l'homme, 1994. In: Revue des Sciences Religieuses, tome 70, fascicule 3, 1996. pp. 418-419

    Chonocephalus transversalis Schmitz

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    Chonocephalus transversalis (Schmitz). (Figs 31­32) Epichonocephalus transversalis Schmitz, 1928: 105. Chonocephalus transversalis (Schmitz). Comb. nov. This species is formally transferred to the genus Chonocephalus as a consequence of synonymising Epichonocephalus with this genus (see above). Material Holotype male (wing only), Bismarck Archipelago, Neupommern, Lewon, 3­ 9 November (MKB). 1 male, Papua New Guinea, Baiyer R., Goroka, 1200 m, 4­12 August 1985, T. Anderson (leg. R. S. George) (UMZC ­ 3­143).Published as part of Disney, R. Henry L., 2002, Revisionary notes on Chonocephalus Wandolleck (Diptera: Phoridae) with keys to species of the Holarctic Region, pp. 1-36 in Zootaxa 60 on page 32, DOI: 10.5281/zenodo.15598

    Simultaneous communication and processor voltage scaling for dynamic and leakage energy reduction in time-constrained systems

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    We propose a new technique for the combined voltage scaling of processors and communication links, taking into account dynamic as well as leakage power consumption. The voltage scaling technique achieves energy efficiency by simultaneously scaling the supply and body bias voltages in the case of processors and buses with repeaters, while energy efficiency on fat wires is achieved through dynamic voltage swing scaling. We also introduce a set of accurate communication models for the energy estimation of voltage scalable embedded systems. In particular, we demonstrate that voltage scaling of bus repeaters and dynamic adaption of the voltage swing on fat wires can significantly influence the system's energy consumption. Experimental results, conducted on numerous generated benchmarks and a real-life example, demonstrate that substantial energy savings can be achieved with the proposed techniques
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