1,721,006 research outputs found
L’anemia nelle infezioni
No full textL'anemia è usualmente osservata nelle infezioni gravi, croniche, infiammatorie e neoplastiche. E' evidenziato il ruolo delle citochine nella patogenesi dell'anemia nelle malattie corniche
Incidence of Severe Streptococcal-Related Diseases in Italian Children in an Era of High Group A Streptococcal Resistance to Macrolides
No full textMacrolides are still widely prescribed for adult and pediatric respiratory infections in Italy despite the fact that it is known that the resistance of group A streptococci has dramatically increased since 1994, The aim of this study was to evaluate the incidence of severe streptococcal-related diseases from 1990 to 1996 on the basis of data derived from computer-generated lists of children hospitalized in 35 Pediatric Departments. The clinical record of each case was reviewed in order to gather data concerning clinical diagnoses, laboratory investigations and antibiotic therapies in the preceding four weeks, Six hundred and twenty of the total of 321,612 hospitalized children had severe streptococcal diseases; the overall annual rate remained stable at 2.13/1000 admissions in 1990 to 1.7/1000 admissions in 1996, Severe diseases were preceded by a microbiologically confirmed acute streptococcal infection treated with antibiotics in only 392 of the 620 children (63.2%), Between 1993 and 1996 (with the exception of 1995), macrolides were more frequently prescribed than beta-lactam antibiotics for acute streptococcal infections that subsequently developed into severe disease. There was no difference in the rate of severe streptococcal complications between the patients adequately treated with antibiotics and those who were inadequately or not treated. Possible explanations for the relatively stable rate of severe streptococcal complications in Italian children could be (1) a relative absence of invasive, rheumatogenic or nephritogenic strains and/or (2) a difference between in vitro and in vivo resistance of group A streptococci to macrolides. Further studies are needed to investigate the biological characteristics of resistant group A streptococcal strains and their relationships to short- and long-term clinical outcomes
Uso degli interferoni nell’epatite cronica C in thalassemia major: studio prospettico
No full textLa ricerca valuta gli effetti dell'interferone ricombinante versus l'interferone linfoblastoide nei pazienti thalassemici con epatite cornica C
Safety and effectiveness of Medtronic MiniMedTM 780G in a neonate with transient neonatal diabetes mellitus: a case report
No full textNeonatal diabetes mellitus (NDM) is a rare disease (ORPHA:224) with an estimated incidence ranging from 1:20,000 to 350,000 live births, with the highest incidence in those countries with high rate of consanguinity. It is usually defined as “a diabetes duration of at least 2 weeks that occurs within the first 6 months of life”. It can be classified as transient (TNDM) or permanent (PNDM), and in a minority of cases it is associated to other syndromes (syndromic diabetes). A genetic aetiology can be recognized in most of the patients.
Up-to-date, more than 30 genes responsible for NDM have been identified [1]. The genetic diagnosis plays a key-role to guide clinicians to choose the appropriate treatment as more than 90% of patients with NDM due to KCNJ11 and ABCC8 mutations can be successfully treated with sulfonylureas, while patients with NDM due to defects of 6q24 seem responsive to different antidiabetic agents [2]. Usually, all the other patients carrying mutations of other genes require a different treatment, with insulin or even, rarely, bone-marrow transplantation. According to the ISPAD guidelines, NDM is a circumstance in which insulin pumps may be beneficial [3].
In this paper, we describe an infant diagnosed with TNDM due to defect in the 6q24 region. He was treated with intravenous insulin infusion and then with an advanced hybrid closed loop system (AHCL), which allowed to discharge the patient and to prevent hypoglycaemic events even during the insulin suspension due to remission phase
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
EAB da arteria ombelicale in neonati da taglio cesareo: influenza di fattori ostetrici, anestesiologici e neonatali
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