168 research outputs found
Characterisation of receptor-specific TNFα functions in adipocyte cell lines lacking type 1 and 2 TNF receptors
No full textAbstractTumour necrosis factor-alpha (TNFα) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including adipocytes through its two distinct cell surface receptors. To address the role of each TNF receptor in the biological actions of TNFα in adipocytes, we have developed four new preadipocyte cell lines. These were established from wild type controls (TNFR1+/+R2+/+) and from mice lacking TNFR1 (TNFR1−/−), TNFR2 (TNFR2−/−) or both (TNFR1−/−R2−/−). All four new cell lines can fully differentiate to form mature adipocytes, under appropriate culture conditions, as judged by cell morphology, expression of multiple adipogenic markers and the ability to mediate agonist-stimulated lipolysis and insulin-stimulated glucose transport. In wild type (TNFR1+/+R2+/+) and TNFR2−/− adipocytes, TNFα stimulated lipolysis and inhibited insulin-stimulated glucose transport as well as insulin receptor autophosphorylation. In contrast, these activities were completely lost in the TNFR1−/−R2−/− and TNFR1−/− cells. Taken together, these studies demonstrate that TNFα-induced lipolysis, as well as inhibition of insulin-stimulated glucose transport are predominantly mediated by TNFR1 and that the presence of TNFR2 is not necessary for these functions. This new experimental system promises to be useful in dissecting the molecular pathways activated by each TNF receptor in mediating the biological functions of TNFα in differentiated adipocytes
Francois Ludger Diard poetry notebook and Mobile scrapbook, W.0025
No full textAbstract: Notebook of this Mobile, Alabama, native's poetry and a scrapbook of newspaper clippings and letters relating to his work.Scope and Content Note: This collection contains a notebook of Diard's poetry and a scrapbook of newspaper clippings and letters relating to his work. Diard annotated many of the poems collected in this 200-page notebook, noting when they were written and/or published. The majority of the notebook contains clippings of poetry published by local newspapers during World War I. Most of these poems are patriotic, praising the sacrifices of Alabama servicemen. Toward the back of the volume are several letters to Diard from the vice-president of the
Mobile Register, Erwin Craighead, soliciting poems for an anthology of Mobile literati.The Mobile scrapbook contains newspaper items clipped from the
Mobile Register, the
Mobile Times, and other Mobile newspapers. The articles were published between 1849 and 1945, with most of the articles published between 1929 and 1945. While most of the items address city events and Mobile's literary community, other items include obituaries and state and national news briefs. Approximately one-quarter of the articles clipped are copies of Erwin Craighead's column "Dropped Stitches From Mobile's Past."Biographical/Historical Note: Francois Ludger Diard, son of Charles August R. and Sarah Antonia Ludgere Diard, was born on 29 October 1883 in Mobile, Alabama. He was the author of many poems, including "We Have Kept the Faith," a response to "We Shall Not Sleep, Tho Poppies Grow in Flanders Fields" written by Lieutenant Colonel Dr. John McRae of Canada while the second battle of Ypres, Belgium, was in progress. He also wrote
The Tree: Being the Strange Case of Charles R. S. Boyington about the 1835 Mobile murder of Nathaniel Frost by Charles Boyington. Diard died in Mobile on 25 March 1955
European Union - The Second Founding
No full textProf. Dr. Ludger Kühnhardt, Director at the renowned Center for European Integration Studies (ZEI) at the University of Bonn is presenting a broadly structured study about the first fifty years of European integration, its geopolitical context and academic reflection. His study is based on the two-fold thesis that since a few years, the European Union is going through a process of its Second Founding while simultaneously changing its rationale. The original founding of European integration in 1957 was based on the notion of internal reconciliation among European states and societies. Since the 1990""s European integration has become, increasingly, a political project with implications for the internal structure of its member states and their societies. At the same time, with the end of the Cold War, the rational of European integration has begun to change: European integration is about a new global role of Europe, its contribution to the management of global affairs and its ability to cope with the effects of globalization on Europe. Inside the EU, the Second Founding is about a new contract between political elites and the people of Europe in order to solidify legitimacy and effectiveness for this unique experiment in European history. Prof. Dr. Ludger Kühnhardt has been Director at the Center for European Integration Studies (ZEI) since 1997. He is author of thirty books and edits the volumes of ZEI at Nomos
No Separation: Christians, Secular Democracy, and Sex. By Ludger H. Viefhues-Bailey
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Church and State following peer review. The version of record Lauren Barbato, No Separation: Christians, Secular Democracy, and Sex. By Ludger H. Viefhues-Bailey, Journal of Church and State, Volume 67, Issue 1, Winter 2025, csae070, https://doi.org/10.1093/jcs/csae070 is available online at: https://doi.org/10.1093/jcs/csae070.
© The Author(s) 2024. Published by Oxford University Press on behalf of the J. M. Dawson Institute of Church-State Studies. All rights reserved. For permissions, please e-mail: [email protected].
This article will be embargoed until 12/10/2026.What happens when a Western secular democracy produces a Christianity of its own? Does it become another formation of the secular, a civil religion, or a cultural religious movement in service of a select body politic? Following in the lineage of Robert Bellah, Talal Asad, and Saba Mahmood, Ludger H. Viefhues-Bailey’s No Separation: Christians, Secular Democracy, and Sex challenges the deployment of political secularisms in three Western nations and argues that such deployments in the twenty-first century have woven populist, anti-textual Christianities into the boundaries delineating borders and citizens. Disconnected from doctrine and institutional authority, these Christianities form cultural religions that Viefhues-Bailey labels civil religion’s “unruly cousin” (p. 24). In his taxonomy, cultural religions lack founding myths and central texts; their usage of history is neither scripturally nor politically coherent; and they are often “coercive” in identifying “who is part of the body politic” and “who is not” (p. 24). The intervention that Viefhues-Bailey makes goes beyond which bodies matter to the state and why. Rather, he concludes that these “exclusionary Christianities” reveal that “the project of democratic governance is profoundly problematic” and strives to envision new theological strategies for liberative democracies (pp. 224–225)
Organ-specific role of the lipogenic transcription factor ChREBP for metabolic adaptation in response to cold exposure and its implications for metabolic diseases
No full textEver since the discovery of active and adequate brown fat depots in adult humans, non-shivering thermogenesis (NST) function of brown adipose tissue (BAT), where oxidation of tissue-stored fats is uncoupled from ATP synthesis and instead used to generate heat for the body, has become a promising avenue for metabolic disease research in the last decade. As BAT utilizes its stored fats for the purpose of generating heat for the body, it also maintains a stable energy storage in the form of fats within brown adipocytes. To prevent replenishment of these fat stores, upon cold stimuli, BAT picks up additional glucose from plasma to be converted into storage triglycerides via de novo lipogenesis (DNL), alongside taking up additional lipids also from plasma. If the cold stimuli are long enough, the same phenomena are observed in white adipose tissue (WAT) as well via a process called browning. These trends make BAT, NST and WAT browning exciting avenues for metabolic disease research targeting type 2 diabetes and obesity, alongside fatty liver diseases and other metabolic conditions. ChREBP, as a glycolytic and lipogenic transcription factor identified more than a decade ago, has been established to be the main driver of DNL in adipocytes and thus has important roles in the processes observed in BAT and WAT during NST and browning, which can have far-reaching implications. The present thesis work evaluates effects and necessity of ChREBP function by analysing its organ-specific roles during metabolic adaptation to cold, in liver, BAT, and WAT via gene expression, protein expression, and tissue uptake data obtained from murine cohorts with ChREBP availability versus deletion, housed under different ambient temperatures.Biochemical EngineeringBSc/B
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