1,721,074 research outputs found
Biomonitoring of exposure to diesel exhaust. Development and application of techniques, using 1-nitropyrene as a marker.
No full textItem does not contain fulltextKatholieke Universiteit Nijmegen, 28 oktober 1999Promotor : Smits, P. Co-promotores : Bos, R.P., Scheepers, P.T.J
Evaluation of the use of 1-nitropyrene, pyrene, and 1-hydroxypyrene as markers of diesel exhaust exposure in underground mining: Results from the biomodem study
No full textThe exposure to diesel exhaust was studied in underground mining of oil shale in Estonia. The purpose of this study was to evaluate different approaches to exposure assessment. Fifty men who drove diesel-powered excavators underground were compared with 50 surface workers who had no known occupational exposure to diesel exhaust. Samples of respirable air were analyzed for 1-nitropyrene and pyrene. Urine samples were collected at the start and after the first and the last shift of the same week, and were analyzed for 1-hydroxypyrene. Although ambient monitoring of 1-nitropyrene indicated a relatively high exposure of underground workers to diesel exhaust compared to surface workers (approximately 10-fold higher), only a small increase in the excretion of 1-hydroxypyerene was observed. Nonoccupational exposures such as smoking, recent consumption of grilled food, and recent proximity to an open fire had a greater impact on urinary excretion of 1-hydroxypyrene than occupational exposure to diesel exhaus
'Incidenten met gevaarlijke stoffen: chemie of hysterie'
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81833.pdf (Publisher’s version ) (Open Access
Advances in the discovery of low-abundance proteins. A report on the "Biomarker Discovery of Mass Spectrometry" Symposium, Amsterdam, The Netherlands, 18-19 May 2006
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50535.pdf (Publisher’s version ) (Open Access
Van spanningsboog tot brug: het bereiken van afstemming over de kwaliteit van werk- en woonomgeving
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80961.pdf (Publisher’s version ) (Open Access
Communicatie via cell broadcast tijdens een chemisch incident. Hoe breng je de bevolking in veiligheid met 200 tekens?
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110611.pdf (Publisher’s version ) (Open Access
The use of biomarkers for improved retrospective exposure assessment in epidemiological studies: summary of an ECETOC workshop.
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70631.pdf (Publisher’s version ) (Open Access)During a scientific workshop the use of biological monitoring in characterization of retrospective exposure assessment was discussed. The workshop addressed currently available methodology and also novel approaches such as in different fields of 'omics'. For use in epidemiology requiring retrospective exposure assessment, biomarker levels should not vary too much over time. If variability in exposure over time is large and differences in exposure between individuals are relatively small, this may lead to underestimation of the exposure-response relationship. This means that, for a sound assessment of health risk, biomarkers that reflect cumulative exposure over a long period of time are preferred over biomarkers with short half-lives. Most of the existing biomarkers such as metabolites in body fluids usually have rather short half-lives, typically less than 1-2 days. Some adducts to DNA show somewhat longer half-lives. The current limit to persistence of biomarkers reflecting cumulative exposure over time is from adducts to haemoglobin with a half-life of 4 months. Some specific organic substances may be more persistent due to storage in adipose tissue or metals in kidneys, nails and hair. The metabonomics, proteomics and present gene expression profiling approaches do not provide a perspective to the availability of more persistent biomarkers and most approaches discussed to date show that it is difficult to interpret study outcomes in terms of exposure to a specific xenobiotic factor. Research efforts should focus on improvement and validation of currently available approaches in the field of addition products to DNA and proteins. Promising new developments may be phosphotriester DNA adducts and adducts to more long-lived proteins such as histones
Monitoring of occupational exposure to diesel exhaust
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mmubn000001_187460590.pdf (Publisher’s version ) (Open Access)Promotores : J. Noordhoek en R. Bos238 p
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