109 research outputs found
Quality of postpartum hemorrhage care. The need for standardization
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157069.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit, 24 mei 2016Promotores : Grol, R.P.T.M., Lotgering, F.K. Co-promotores : Hermens, R.P.M.G., Scheepers, H.C.J
Maintenance tocolysis with nifedipine in threatened preterm labor
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132632.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 18 december 2014Promotores : Lotgering, F.K., Mol, B.W.J. Co-promotores : Spaanderman, M.E.A., Scheepers, H.C.J
Bridging the gap: implementing evidence-based pharmacotherapy for pregnant women and children
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319717.pdf (Publisher’s version ) (Open Access)Drugs are processed differently by pregnant women and children’s bodies compared to adults who are not pregnant. However, evidence for safe and effective treatments in these groups is lacking. The first part of this thesis highlights gaps in information on drug use in children. It maps differences between asthma guidelines from the Netherlands and the United Kingdom and shows that most apps used to calculate children’s doses have not officially been approved in the European Union. The second part addresses the need for evidence-based doses for pregnant women and fetuses, summarising views from doctors and women. It introduces a new method using virtual models of pregnant women and babies to determine effective doses, with sertraline as an example. This method is now used in the Netherlands. Additionally, the thesis presents a new way to make informed decisions about medications during pregnancy, considering the risks and benefits for both women and fetuses.Radboud University, 06 juni 2025Promotores : Wildt, S.N. de, Franklin, B.D. Co-promotor : Scheepers, H.C.J.259 p
Birth spacing and adverse perinatal outcomes.
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50919scheepers.pdf (Publisher’s version ) (Closed access
Armature reaction and armature leakage in salient-pole type synchronous machines
No full textElectrical Engineering, Mathematics and Computer Scienc
Prediction of propeller-induced hull-pressure fluctuations
No full textThe cavitating propeller often forms the primary source of noise and vibration on board ships. The propeller induces hydroacoustic pressure fluctuations due to the passing blades and, more importantly, the dynamic activity of cavities in the propeller’s immediate vicinity. The accurate prediction of the resulting vibratory hull-excitation forces is indispensible in the ship design process, but is not always warranted. From this follows the main objective of the thesis, which is the development of improved prediction capabilities for propeller-induced hullexcitation forces based on experimental and computational procedures. On the basis of experience and a literature study several topics have been selected that are considered most in need of improvement. On the experimental side, the model scale effect on the effective ship wake has been studied. An improved model testing procedure has been developed, which is based on the use of a geometrically non-similar model hull form designed by means of a RANS method. It is shown how the closer resemblance of the model’s wake field with that of the real ship improves the similarity of the propeller cavitation dynamics and thereby the prediction of the resulting first blade rate order hull-pressure fluctuations. On the basis of the boundary element method, a computational method has been developed for the computation of the scattering effect of the hull on incident pressures caused by propeller noise sources. The method has been validated with model scale experiments on propellers with and without cavitation. The same boundary element method has been used to correct for the influence of model hull vibrations on the assessment of hull-excitation forces. Guidelines have been derived for the execution of model scale experiments so as to minimize vibration-induced hull pressures. Inverse scattering techniques have been applied to the determination of the propeller source strength from measured or computed hull pressures. On the basis of the source strength, the pressure distribution on the hull may be derived from which effective vibratory excitation forces follow. It is proposed to use propeller noise source strenghts or hullexcitation forces instead of local pressure amplitudes in contract specifications. It is strongly recommended that for the correct prediction of pressure fluctuations at higher orders of the blade passage frequency, tip and leading edge vortex dynamics are studied as well as the effect of gas content on the dynamics of the cavitating vortexMarine TechnologyMechanical, Maritime and Materials Engineerin
Book Reviews
No full textBook 1Book Title: Health Care as Human RightBook Author: Ed. by Anton van NiekerkPp. 115. Stellenbosch: Unit for Bioethics, University of Stellenbosch. 1993. ISBN 0-79720429- 6.Book 2Book Title: Psychosis and its ManagementBook Author: A.E. GangatPp. xvii + 169. Durban: Valentine Bedford. 1992. ISBN 0-620-16940-0.Book 3Book Title: Health Care in South Africa: Structure and DynamicsBook Authors: H.C.J. van Rensburg, A. Fourie & E. PretoriusPp. xix + 438. lllustrated. Pretoria: Academica. 1992. ISBN 0-86874-471-9Book 4Book Title: Guidelines for Cholera ControlBook Author: WHOPp. vi + 61. (in English; French and Spanish in preparation). $16,20. Geneva: WHO. 1993. Order No. 1150398. ISBN 92-4-15444-9X
Consecutive intra-umbilical vein injection of misoprostol and intravenous sulprostone in the management of retained placenta
No full textConsecutive intra-umbilical vein injection of misoprostol and intravenous sulprostone in the management of retained placenta (RP). The general accepted treatment of RP is manual removal of the placenta (MRP), but medical intervention protocols were suggested. We evaluate a protocol of using intra-umbilical vein injection of misoprostol followed, if necessary, by intravenous sulprostone. A reduction in the need for MRP and less blood loss was expected. Cohort A (1 January 2007 to 31 September 2008), managed by an expectative protocol including active management of the third stage of labor and if necessary MRP performed 60 min after birth of the baby, was compared with cohort B (1 April 2009 to 31 December 2010) managed by medical intervention protocol. This protocol consisted of intra-umbilical vein injection of misoprostol and if not successful, 250 mu g of sulprostone was given intravenously in 30 min. All vaginal deliveries after 24 weeks of gestation, with RP after 20 min and blood loss <500 mL were included. An intention to treat analysis was performed, with the need for MRP as the primary outcome. Baseline characteristics were similar. In cohort A, 275 women met the inclusion criteria and 57 (20.7 %) women needed MRP. In cohort B, 219 women were included and 35 (16 %) women needed MRP. There was no significant difference in number of MRP, the amount of blood loss and other secondary outcomes. We conclude that the use of intra-umbilical vein injection of misoprostol and intravenous sulprostone consecutively, does not reduce the number of MRPs as well as the total amount of blood loss in women with RP after 20 min. The study shows that changing obstetric management by extrapolating results from specific study groups to a general population may lead to other results
Anxiety during an IVF procedure: the influence of dietary sodium restriction, several infertility characteristics and early pregnancy
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Carbohydrate solution intake during labour just before the start of the second stage: a double-blind study on metabolic effects and clinical outcome
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