1,720,961 research outputs found
The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension.
No full textHypertension and type 2 diabetes mellitus (T2DM) cause endothelial dysfunction
probably through increased oxidant stress. Paraoxonase (PON1) is an high-density
lipoprotein (HDL)-linked anti-oxidant enzyme whose capacity is influenced by a
genetic polymorphism at codon 192. In the present study we have investigated the
role of PON1 polymorphism on endothelial function in subjects with T2DM with or
without hypertension. Three groups of male subjects were enrolled: 65 healthy
control subjects without T2DM or hypertension (CON), 51 with only T2DM (DM), and
67 with both hypertension and T2DM (HYP+DM). The PON1 Gln192Arg polymorphism was
determined by polymerase chain reaction (PCR) amplification and restriction
analysis. Endothelial function was evaluated as flow-mediated vasodilatation
(FMD) of the brachial artery after forearm ischemia. Data were analyzed according
to the presence or absence of the Arg allele. Subjects with T2DM had markedly
impaired FMD, compared with those of the CON group. In the CON and HYP+DM groups
no difference was observed in FMD between subjects homozygous for the Gln allele
and those carrying the Arg allele. In the DM group FMD was lower among those
carrying the Arg allele compared with Gln/Gln homozygotes (2.1+/-2.4% vs.
6.2+/-5.2%, p=0.002). In conclusion, the present findings demonstrated that FMD
was less impaired in normotensive diabetic subjects homozygous for the Gln
allele, consistent with the notion that this isoform has a more effective
antioxidant action that serves to protect circulating low-density lipoprotein
(LDL). Hypertension seems to abolish the protective effect of the Gln isoform.
These findings, however, warrant further investigation to clarify their clinical
import
Body mass index, metabolic syndrome and carotid atherosclerosis.
No full textOBJECTIVE: Body fatness and fat distribution are widely accepted as coronary
heart disease risk factors. In this study, we have evaluated the contribution of
generalized adiposity, assessed by body mass index (BMI), to carotid
atherosclerosis, in participants with or without metabolic syndrome (MetS).
METHODS: We have analysed 840 female and 1002 male participants in a regional
Cardiovascular Disease Prevention Campaign. Blood glucose and lipids were
analysed by standard methods. According to BMI, calculated as weight (in
kilograms)/height (in square metres), participants were divided into normal
weight (BMI <25 kg/m2), overweight (BMI between 25 and 29.9 kg/m2) and obese
(BMI>29.9 kg/m2). Carotid atherosclerosis was evaluated by echo Doppler.
RESULTS: Blood pressure, waist circumference, triglycerides and glucose were
significantly higher, and high-density lipoprotein was lower, in overweight and
obese participants, compared with normal weight. MetS was more frequent among
obese and overweight than normal-weight participants (51.7 vs. 21.5 vs. 9.8%,
respectively). The prevalence of carotid atherosclerosis was 45.29% in
participants with MetS, significantly higher than in participants without MetS
(33.04%, P<0.0001), but it was similar across the three weight categories.
Furthermore, in multiple regression analyses BMI was not significantly associated
with carotid atherosclerosis.
CONCLUSION: The present findings suggest that increasing body weight favours the
clustering of coronary heart disease risk factors. Overweight and obesity,
however, do not independently associate with carotid atherosclerosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
L’integrina αvβ3 modula l’adesione, la proliferazione e la produzione di proteasi in cellule di tumori linfoidi umani
No full textDispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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