1,721,142 research outputs found
Recurrent hepatocellular carcinoma: A Western strategy that emphasizes the impact of pathologic profile of the first resection
No full textHepatocellular carcinoma (HCC) often recurs after curative resection,
and thus the optimal treatment strategy to treat recurrences remains uncertain.
We analyzed the results of different options to treat recurrent HCC and
emphasized the impact of pathologic patterns of the tumor at initial resection.
METHODS: Between 2000 and 2014, 293 patients underwent potentially curative
hepatic resection for HCC. Among them, 150 experienced a recurrence and have been
treated by repeat resection (RR), radiofrequency ablation (RFA), salvage liver
transplantation (SLT), transarterial chemoembolization (TACE), or conservative
treatment, including systemic or targeted chemotherapy. Clinical outcomes were
analyzed and compared between the treatment groups, focusing on clinical and
pathologic characteristics of the tumor at initial resection.
RESULTS: After a median follow-up of 26 months, the overall survival (OS) at 1,
3, and 5 years after recurrence was 62%, 48%, and 40%, respectively. Survival
rates were greater in patients treated by a curative approach (RR, RFA, SLT) than
those treated by TACE, with 5-year OS of >70% and 37%, respectively. Univariate
analysis showed satellitosis and microvascular invasion (MVI) at initial
resection as negative prognostic factors of survival after recurrence (P < .05).
On multivariate analysis, type of treatment was the only independent factor
associated with survival. A subgroup analysis showed that RR/RFA led to better
survival outcomes than TACE for early stage intrahepatic recurrences in the
absence of satellitosis or MVI on the primary resected tumor.
CONCLUSION: Curative treatments of recurrent HCC improve patient survival.
Satellitosis and MVI on the primary resected specimen may be used as selection
criteria for the best treatment strategy for intrahepatic recurrences
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Optimizing marginal liver grafts : development of an ex-vivo perfusion system and metabolic manipulations via an oxygenated dynamic sequence
No full textEn raison de la pénurie d'organes, des greffons hépatiques"marginaux" tels que les foies stéatosiques sont de plus en plus proposés aux équipes de transplantation, bien qu'ils tolèrent mal l’ischémie-reperfusion. La perfusion oxygénée ex-vivo des greffons hépatiques permet de minimiser l’ischémie-reperfusion, mais la variabilité des systèmes, des paramètres et l’importance des coûts des machines disponibles limitent sa généralisation. En 2014, l'équipe chirurgicale de la Pitié Salpêtrière et des ingénieurs de l'UTC ont conçu un prototype de dispositif de perfusion hépatique oxygénée. Ce projet de thèse s’est inscrit dans la continuité de ces travaux préliminaires et s’est développé autour de plusieurs axes: 1) développement d’un système de perfusion ex-vivo correspondant aux exigences métaboliques et hémodynamiques requises par la physiologie, mais aussi aux prérequis techniques définis par notre équipe. Ce développement a abouti à l’élaboration d’un prototype en partenariat avec un industriel (Livanova®).2) mise au point d’un protocole de perfusion dynamique spécifique (de l'hypo à la normothermie) avec ce système sur des foies humains « super marginaux ». Ce protocole de perfusion dynamique « cold-to-warm » sans interruption a été testé avec succès sur notre premier prototype et a permis une simplification de la séquence de perfusion par rapport aux technologies existantes. 3) évaluation du métabolisme de greffons stéatosiques perfusés et de l’efficacité d’un cocktail pharmacologique "défattant" permettant l'activation de la β-oxydation et l’export des lipides, évalué in vitro puis sur 7 foies humains ultra marginaux dont 5 stéatosiques perfusés sur notre circuit.Due to organ shortage, marginal liver grafts such as steatotic livers are increasingly proposed to transplantation teams. However, these livers have a low ischemia-reperfusion tolerance. Ex-vivo oxygenated perfusion of liver grafts represents a solution to minimize ischemia-reperfusion, but the variability of systems, parameters, and the high cost of available machines limit its expansion. In 2014, the surgical team at Pitié Salpêtrière and engineers from UTC designed a prototype of oxygenated liver perfusion device. This thesis is a continuation of this preliminary work and developed around several axes:1) development of an ex-vivo perfusion system corresponding to the metabolic and hemodynamic requirements of liver physiology, but also to the technical requirements defined by our team. This development led to the elaboration of a prototype in partnership with an industrial company (Livanova®).2) development of a specific dynamic perfusion protocol (from hypo to normothermia) with this system on "super marginal" human livers. This dynamic cold-to-warm perfusion protocol without interruption was successfully tested on our first prototype and allowed a simplification of the perfusion sequence compared to existing technologies.3) Evaluation of the metabolism of perfused steatotic grafts and of the efficacy of a defatting pharmacological cocktail. This second step, based on preliminary in vitro results showing the efficacy of a defatting cocktail on the activation of β-oxidation lipid export, led us to inject this cocktail into 7 ultra-marginal human livers, 5 of which were steatotic grafts perfused on our circuit with the "cold-to-warm" protocol
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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