1,721,130 research outputs found
Re: Marzia Del Re, Elisa Biasco, Stefania Crucitta, et al. The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients. Eur Urol 2017;71:680–7
No full textPalliative sedation in end-of-life care
No full textPURPOSE OF REVIEW: The aim of this review was to present and comment on recent data published on palliative sedation in palliative and end-of-life care. Palliative sedation is a medical procedure used to deal with the refractory symptoms occurring in the advanced stages of cancer. It has clinical, nursing, relational and ethical implications, making it a highly sensitive issue. RECENT FINDINGS: Over the last 12 months, a number of authors have published interesting new findings on different areas of palliative sedation, that is prevalence, indications, monitoring, duration and choice of drugs. In particular, a clear definition of palliative sedation and of its more pronounced form, deep continuous sedation (DCS), has emerged. It has been confirmed that, when performed in the correct way and with the right aims, palliative sedation does not have a detrimental impact on survival. SUMMARY: Recent findings confirm that palliative sedation is an integral part of a medical palliative care approach and is needed in certain clinical situations. It is a legitimate clinical practice from any ethical point of view. While oncologists should have a basic knowledge of the procedure, its in depth study is a core competency for palliative care physicians. Copyright © Lippincott Williams & Wilkins
Palliative sedation for intolerable suffering
No full textThe purpose of this review is to provide an update on palliative sedation in palliative and end-of-life care. Palliative sedation is the medical procedure used to deal with refractory symptoms in advanced cancer patients when all other specific approaches have failed. RECENT FINDINGS: Palliative sedation, in the strictest sense of the term, is a proportionate (proportionate palliative sedation, PPS) and intrinsically variable procedure used on an individual basis to relieve refractory symptoms in terminally ill patients, without the intention of hastening death. Completely separate from any other end-of-life decision and not intended to hasten death, palliative sedation has been shown not to have a detrimental impact on survival. SUMMARY: To maintain palliative sedation as a legitimate clinical procedure from any ethical or clinical point of view, it must be limited to the restricted area for which it was conceived, that is, relief from refractory suffering as deemed necessary by a patient and by an experienced palliative care team. In this way, there is no risk of associating palliative sedation with other end-of-life decisions. Close collaboration is needed between oncologists and palliative care physicians for this clinical procedure. Copyright © Lippincott Williams & Wilkins
Body mass index (BMI) and benefit from adjuvant chemotherapy in breast cancer: is it enough?
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Esoterismi bianchi e neri. Mondi contigui nella letteratura sudafricana contemporanea
Full text linkNel contesto di una riflessione che riguarda se e in che modo un riesame delle tradizioni ermetiche/esoteriche ci aiuti a interrogare e a comprendere la nostra contemporaneità, il saggio prende in esame due testi della letteratura sudafricana contemporanea, Dimetos di Athol Fugard e The Heart of Redness di Zakes Mda. Il primo è un dramma in due atti del 1975, che è stato effettivamente recepito come esoterico – un testo oscuro per un’elite di iniziati – nella produzione di Fugard, tutt’ora considerato uno dei maggiori drammaturghi di lingua inglese. Il romanzo Heart of Redness (2000) è di uno scrittore sudafricano di origine Xhosa, che nasce come drammaturgo e si muove poi verso la narrativa con voce originale. In Dimetos traspare come in un palinsesto la tradizione europea, mentre in Heart of Redness aspetti oscuri e magici, legati alle culture africane, emergono a contatto con la cultura bianca coloniale dell’Ottocento o riaffiorano nel presente con una serie di conseguenze interessanti di tipo epistemologico e culturale. Cosmologie che sottolineano la posizione di esseri umani quali intermediari tra un’entità creatrice e ordinatrice e il mondo materiale, tra macrocosmo e microcosmo, storia ed eternità, offrono nuove riflessioni su soggettività e temporalità, come una forma di divenire dall’interno dell’immobilità del tempo
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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