102,120 research outputs found
1973 in first person: Aesthetic responses to horror|El '73 en primera persona: respuestas estéticas al horror
No full textEl ’73 en primera persona: respuestas estéticas al horror (editado por) Rubí Carreño Bolívar, Laura Scarabelli, Federico Cantoni y Giuseppe Cali
Imaginar el pasado, fabricar el presente. El rol del testimonio en "La dimension desconocida" de Nona Fernández
No full text
Albendazole: a new therapeutic regimen in cutaneous larva migrans
No full textVarious therapeutic modalities have been used to treat cutaneous larva migrans, including physical treatments (cryotherapy), topical drugs (tiabendazole), and systemic drugs (tiabendazole, albendazole, and ivermectin). Physical treatments are often ineffective and not devoid of side-effects. Topical tiabendazole is difficult to find in many countries; it is effective orally but frequently causes side-effects. Ivermectin has been used in a small number of patients
Structure and sequence determinants of aggregation investigated with molecular dynamics
No full textSpontaneous self-assembly and amyloid formation are a general property of many polypeptides and the information controlling these processes is encoded in the sequence. This determines the form and structural features of the interacting partners that regulate the properties of the final aggregates. Understanding the correlations between sequence, structure and dynamics in peptides and proteins at an atomistic level of resolution still represents one of the grand challenges of modern biological chemistry. In this context, computer simulations represent a valuable approach to understand recognition and spontaneous self-organization, processes that cannot be directly observed experimentally. Herein, we will discuss cases illustrating the extent to which simulations can be used to understand the self-organization properties of natural and designed amyloidogenic peptide sequences. The simulations provide evidence for the influence of specific interactions with well defined stereochemical constraints on fibril formation. The results from our and other groups suggest that simulations can be applied to detect the critical physico-chemical determinants of a certain process and can be helpful in the design of new chemical systems and experiments
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