305,272 research outputs found
I fattori che limitano lo sviluppo del mercato delle tecnologie di bonifica dei siti contaminati e la validazione della tecnologia innovativa HPSS quale strumento per abbattere le barriere di mercato
No full textIn the first part of the present work the results of the European project Eurodemo are reported, where an analysis of the remediation technologies market has been performed also identifying the bottlenecks which are slackening it at European and local level. Between the strategies to pull down these barriers it is appeared important the development of an European Environmental Technology Verification System (EETV). In fact, the demonstrative and the verification phases of a new techniques are pointed out as significant to boost their enter on the market. In the second part, the work reports the phases of the verification process of an innovative Stabilization/Solidification (S/S) techniques which is based on the High Performance Concrete (HPC) knowhow. The research was focus on the selection and application of the more suitable evaluation tests to measure the S/S performance, such as leaching and physical-mechanical test. The good results of the cross-examination analysis performed pulled down many different barriers both regarding the control authorities and other stakeholders.Il presente lavoro riporta, nella sua prima parte, i risultati principali del progetto europeo Eurodemo nell’ambito del quale si è svolta una analisi del mercato delle tecnologie di bonifica individuando i meccanismi e degli ostacoli che ne stanno rallentando lo sviluppo sia a livello europeo che locale. Tra le strategie per abbattere tali barriere risulta importante l’istituzione di un European Environmental Technology Verification System (EETV), poiché si è evidenziato che la fase dimostrativa e di validazione di una nuova tecnica sono significative per agevolarne l’entrata nel mercato. Nella sua seconda parte (quella sperimentale), il lavoro riporta le fasi del processo di validazione di una innovativa tecnologia di Stabilizzazione/Solidificazione (S/S) che sfrutta le tecniche costruttive dei calcestruzzi ad alte prestazione (High Performance Concrete). Nello specifico la ricerca si è concentrata nell’individuare, selezionare ed applicare i più idonei sistemi valutativi dell’efficacia delle tecniche di S/S, quali test di cessione e prove fisico-meccaniche. I buon esito delle analisi effettuate in contradditorio hanno portato a eliminare molte barriere sia nel confronto con gli enti di controllo che gli altri portatori di interesse
Bacterial melanin production by heterologous expression of 4 hydroxyphenylpyruvate dioxygenase from Pseudomonas aeruginosa
No full textPyomelanin is a reddish-brown pigment produced by bacteria of different genera and plays a variety of physiological roles. Proposals have been regarding the use of pyomelanin in various environmental, industrial and, more recently, cosmetic applications. In Pseudomonas aeruginosa, the enzyme 4‐hydroxyphenylpiruvate dioxygenase (Hpd) converts 4-hydroxyphenylpiruvate into homogentisic acid, which represents the key intermediate for melanin biosynthesis. This work aimed to obtain Escherichia coli cells overexpressing hpd gene from the PAO1 strain to produce large amounts of pyomelanin for biotechnological purposes. The recombinant dioxygenase expression gave E. coli JM109 the ability to produce pyomelanin. A series of biotransformations led us to choose the best experimental conditions for pyomelanin production. Cells were grown at the mid-exponential phase in a mineral medium with added glucose 10 mM as carbon and energy sources and casamino acid 0.2% w/v as an amino acid source. The administration of tyrosine 1 mM after 30 min of exposure to arabinose 1% w/v made it possible to purify 213 mg/L of pyomelanin after 6 days of biotransformation. In addition to the interesting biotechnological outcomes, the resulting expression system supports the correlation between the hpd gene from P. aeruginosa PAO1 and pyomelanin synthesis
Scanner intraorale e facciale, chirurgia guidata e carbonio. Il futuro dell’odontoiatria? = Intraoral and facial scanner, guided surgery and carbon. The future of dentistry?
No full textOBIETTIVI: Presentazione di un caso clinico caratterizzato da un workflow totalmente digitale eseguito grazie all’ausilio di scanner intraorale, software di progettazione di chirurgia guidata e scanner facciale per la produzione del restauro protesico, finalizzato con una sottostruttura in carbonio ed elementi singoli in zirconia 600 MPa.
MATERIALI E METODI: Paziente donna di anni 57 si presenta all’attenzione degli autori, presso la Clinica Odontoiatrica Giorgio Vogel di Milano, richiedendo la riabilitazione protesica dell’arcata superiore. La paziente è portatrice di una protesi totale rimovibile supportata da 4 attacchi (cappette su radici con attacco a sfera) fissati su elementi ormai parodontalmente gravemente compromessi, caratterizzati da algia alla percussione e mobilità di 2° grado. La richiesta della paziente è indirizzata verso una riabilitazione fissa e, dopo avere analizzato gli esami radiografici, si propone l’avulsione degli elementi residui e la produzione di un restauro protesico fisso implanto- supportato. Si decide di utilizzare un approccio totalmente digitale utilizzando scanner intraorale, chirurgia computer-guidata e scanner facciale per la progettazione della riabilitazione.
Viene eseguita una scansione della protesi totale rimovibile con uno scanner intraorale e dal file STL così ottenuto il laboratorio ricava una dima radiologica. Dopo avere valutati la stabilità e il corretto posizionamento nella cavità orale della paziente si esegue una tomografia computerizzata conebeam. Si procede quindi alla progettazione dell’intervento, con il posizionamento virtuale degli impianti e della relativa dima chirurgica tramite software dedicato. Vengono posizionati 6 impianti bone level in chirurgia computerguidata attraverso un approccio flapless. Trascorse 10 settimane si procede al posizionamento degli scan abutment e alla rilevazione delle posizioni degli impianti attraverso una scansione intraorale. Inoltre, è stata effettuata una scansione facciale per consentire al laboratorio di ottenere tutti i parametri del volto al fine di produrre un restauro perfettamente integrato nel viso della paziente. Viene eseguita una prova protesica con un restauro in PMMA per analizzare i risultati funzionali ed estetici e, una volta ottimizzati e ottenuta l’accettazione da parte della paziente, si procede con il restauro definitivo, il quale è stato realizzato producendo una sottostruttura in carbonio sulla quale sono stati applicati, con tecnica adesiva, i singoli elementi realizzati in zirconia.
RISULTATI E CONCLUSIONI: L’utilizzo di queste tecnologie ha consentito l’inserimento degli impianti in posizione protesicamente guidata, garantendo così un restauro funzionale ed estetico. Inoltre, grazie all’approccio flapless il discomfort chirurgico per la paziente è stato ridotto al minimo. Grazie alla scansione facciale è stato possibile condividere con il laboratorio informazioni fondamentali relative al volto e alla mimica della paziente, consentendo così di ottenere una riabilitazione in grado di integrarsi al meglio all’interno del viso e che rispettasse le proporzioni fisionomiche e funzionali. La scelta di un materiale come il carbonio ha consentito inoltre di ottenere un restauro resistente ed estremamente leggero e l’utilizzo della zirconia 600 MPa per la produzione degli elementi singoli ha garantito robustezza, con risultati sovrapponibili ai classici altri materiali estetici.
SIGNIFICATO CLINICO: A differenza della chirurgia computer- guidata e delle impronte rilevate con scanner intraorali che godono ormai di ampia letteratura dedicata, la scansione intraorale e l’utilizzo del carbonio come materiale per la sottostruttura difettano di un numero ridotto di applicazioni odontoiatriche. Nello specifico, inoltre, il caso descritto presenta un limitato follow- up, ma le impressioni cliniche relative alla precisione del risultato chirurgico e alla funzionalità del restauro ottenuto sono estremamente positive e promettenti per ulteriori applicazioni del protocollo descritto.OBJECTIVES The presentation of a clinical case characterized by a totally digital workflow, effected by means of an intraoral scanner, software design of computer-guided surgery and a facial scanner for the production of prosthetic restoration, finalized with a substructure in carbon and single zirconia crowns 600 MPa. MATERIALS AND METHODS The patient was a 57-year-old woman and came to the attention of the authors, at Dentistry Clinic Giorgio Vogel in Milan, requesting prosthetic restructuring of the superior dental arch. The patient had a removable complete denture supported by 4 attachments (root spherical connections) fixed onto elements periodontally severely compromised, characterized by pain in percussion and 2nd degree mobility. The request of the patient was orientated towards a fixed re habilitation, and, after a radiographic analysis, the proposed solution was the avulsion of residual elements and rehabilitation through the production of an implant-supported fixed prosthesis. It was decided to utilize a totally digital approach using an intraoral scanner, computer-guided surgery and facial scanner for the rehabilitation design. A scan of the total removable prosthesis is performed with an intraoral scanner, and from the STL file thus obtained the laboratory obtains a radiological tem plate. After evaluating its stability and correct positioning in the patient’s oral cavity, a cone-beam computed tomography is per formed. Once the TC cone-beam had been executed, the surgery operation design followed, with the virtual positioning of the implants and of the relative surgical template through dedicated software. Six bone level implants in computer-guided surgery through a flapless approach were then positioned. After 10 weeks the positioning of the scan abutment took place together with the identification of the positions of the implants through an intraoral scan. Furthermore, a facial scan was effected to permit the laboratory to obtain all the facial parameters which produced a perfect integration with the face of the patient. A prosthetic test with restoration in PMMA was carried out to analyze the functional and cosmetic results. Once optimized and the patient was satisfied, the definitive restoration took place, which was realized by producing a carbon substructure on which single zirconia crowns were applied with adhesive technique. RESULTS AND CONCLUSIONS The use of this technology permit ted the insertion of the implants in a prosthetically guided position, ensuring a functional and aesthetic restoration. Furthermore, thanks to the flapless approach, surgical dis comfort for the patient has been reduced to a minimum. Thanks to the facial scan it was possible to share with the laboratory fundamental information relative to the face and to the facial expressions of the patient, thus permitting a rehabilitation capable of integrating in an optimal way with the face and which took account of the physiognomical and functional proportions. Choosing carbon as a material permitted the realization of a resistant and extremely light resto ration, and the utilization of zirconia 600 MPa for the production of the single crowns guaranteed resilience, with results comparable to other esthetic materials. CLINICAL SIGNIFICANCE Unlike computer-guided surgery and impressions taken with intra oral scanners which now enjoy extensive dedicated literature, intraoral scanning and the use of carbon as a material for the sub structure present a small number of dental applications. The case described has a limited follow-up, but the clinical impressions relating to the precision of the surgical result and the functionality of the restoration obtained are extremely positive and promising for further applications of the described protocol
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Integrin in substrate adhesion and phagocytosis by haemocytes of the colonial ascidian Botryllus schlosseri.
No full textFIG. 4 in A nearly complete skeleton of the oldest definitive erycine boid (Messel, Germany)
No full textFIG. 4. — Frontal: A-D, left frontal of HLMD-Me 9723, holotype of Rageryx schmidi n. gen., n. sp., in dorsal, ventral, lateral, and anterior views, respectively; E-H, left frontal of Eryx johnii BM 1930.5.8.31 in dorsal, ventral, lateral, and anterior views, respectively; I-L, left frontal of Lichanura trivirgata CM 145332 in dorsal, ventral, lateral, and anterior views, respectively. Scale bar: A-D, 1 mm; E-L, 2 mm.Published as part of Smith, Krister T. & Scanferla, Agustín, 2021, A nearly complete skeleton of the oldest definitive erycine boid (Messel, Germany), pp. 1-24 in Geodiversitas 43 (1) on page 9, DOI: 10.5252/geodiversitas2021v43a1, http://zenodo.org/record/448644
Figure 1 in The skull of the Upper Cretaceous snake Dinilysia patagonica Smith-Woodward, 1901, and its phylogenetic position revisited
No full textFigure 1. Holotype of Dinilysia patagonica (MLP 26–410). Skull in dorsal (A), ventral (B), right lateral (C), and posterior (D) views; fragmentary right dentary in lingual (E) and medial (F) views; right compound bone in dorsal view (G) and left compound bone in dorsolateral view (H).Published as part of Zaher, Hussam & Scanferla, Carlos Agustín, 2012, The skull of the Upper Cretaceous snake Dinilysia patagonica Smith-Woodward, 1901, and its phylogenetic position revisited, pp. 194-238 in Zoological Journal of the Linnean Society 164 (1) on page 196, DOI: 10.1111/j.1096-3642.2011.00755.x, http://zenodo.org/record/540555
Six-mm versus 10-mm long implants in the rehabilitation of posterior edentulous jaws : a 5-year follow-up of a randomised controlled trial
No full textTo compare the clinical outcome of 6-mm and 10-mm long implants in partially edentulous posterior areas.
MATERIALS AND METHODS:
Twenty-four patients, with a partially edentulous area in the jaws with a height and width allowing the positioning of 2 to 3 adjacent 10 × 4.1 mm implants without any augmentation procedure, were randomly allocated according to a parallel group design to receive 6-mm long or 10-mm long implants. A total of 54 implants were placed (26 × 6 mm and 28 × 10 mm implants). Patients were restored 8 weeks after surgery and were followed for 5 years. Outcome measures were prosthesis and implant survival, as well as marginal bone level changes and complications.
RESULTS:
After 5 years, 18 patients were available. One 6 mm implant failed during the healing period and its related prosthesis could not be placed. No implants were lost after loading. The 6 mm group registered 5 complications (1 mucositis, 3 prosthesis decementations and 1 chipping), while only 3 were registered in the 10 mm group (2 decementations and 1 chipping). The difference in complications between the two groups was not statistically significant (P = 0.39). Marginal bone loss at 5 years was 0.43 and 0.24 mm with the 6 mm and 10 mm groups, respectively (not statistically significant; difference between the two groups 0.19 mm; SD 0.23 mm; 95% CI -0.34;0.73; t test P = 0.42) CONCLUSIONS: Implant and prosthetic survival and success rates were similar between prostheses supported by 6-mm or 10-mm long implants. Conflict-of-interests statement: The present study was supported by grant 369_2004 from ITI, Basel, Switzerland used to provide free implants and prosthetic components to the patient. Authors declare no conflict of interest
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Stratification of prosthetic complications by manufacturer in implant-supported restorations with a 5 years’ follow-up: systematic review of the literature
No full textINTRODUCTION:
Prosthetic complications on implant-supported restorations have been documented in several papers published in the literature. Several manufacturers are present on the market but results are often cumulated and may thus be misleading. The objective of the present review is to assess the prosthetic complications of implant-supported restorations with particular interest of the results obtained with prostheses from different manufacturers.
EVIDENCE ACQUISITION:
A manual search of Medline/PubMed was carried out up to June 2016, yielding a total of 6832 articles, which were narrowed down to 1450, then 347 abstracts to include 55 papers after full text reading. Papers with at least 5 years of follow-up reporting on prosthetic complications of single and fixed partial prosthesis were included. Prosthetic complications were divided into mechanical and technical complications, and reported in a table.
EVIDENCE SYNTHESIS:
Overall 14.4% of prosthetic complication was found for a total of 6623 restorations followed for an average of 7.4 years (range 5-16 years). Results where then sorted and compared. Single crowns were affected by 1.4% of mechanical complications and 10.9% of technical complications after a mean of 7.4 years. Fixed partial prosthesis were affected by 2.5% of mechanical complications and 18% of technical complications. Screw-retained and cemented restorations were calculated to have a 5 years rate of complications of 21.2% and 9.3%, respectively, which demonstrated a statistically difference with fisher exact test with P<0.1. Only 3 manufacturers presented more than 10 articles and were directly compared with Fisher's exact test with P<0.1. The incidence of overall complications was estimated to be after 5 years of 11.2%, 10.8% and 13.8% for Straumann, Nobel, and Astratech, respectively, but dividing results in mechanical and technical complications, gave different results. Straumann was estimated to have less mechanical complications after 5 years in respect to Nobel and Astratech, but the three were similar for technical complications.
CONCLUSIONS:
although studies present very different material and methods and do not report all data, some conclusions can be made. The difference between mechanical complications lead the authors to suppose that there might be a difference in results obtained by different implant abutment connections. It is also noticed that all papers were published by expert clinicians and universities research centers that apply rigid surgical and prosthetic protocols and use original abutments
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