101,958 research outputs found
The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels.
No full textElevated factor VIII (FVIII) levels are a recognized risk factor for venous
thrombosis. Recently, family studies suggested that the G allele of the 3951C/G
(D1241E) FVIII polymorphism is associated to lower FVIII activity. We
investigated in case-control studies both biological effects (FVIII levels and
activated protein C sensitivity ratio) and clinical associations (venous
thromboembolism) of the D1241E change. Among 145 healthy and 150 thrombotic
women, not carriers of known thrombophilic defects, the 1241E allele was
associated with 11% reduced (t-test, P<0.05) FVIII levels. The effect on
activated protein C sensitivity ratio was not statistically significant.
Carriership of the 1241E allele, potentially conferring protection from
thrombosis, was found in 22.8% of controls and in 15.3% of cases. In an
additional cohort of factor V Leiden carriers (n=283), carriership of the 1241E
allele was 25.2% among 143 asymptomatic subjects and 17.1% among 140 thrombotic
patients. Our data do not indicate a specific interaction with factor V Leiden.
These genotype distributions suggest a mild protective effect from venous
thrombosis conferred by 1241E FVIII, masked by other genetic and/or
environmental components, and detectable only in very large population studies.
Our findings point toward the presence of genetic determinant of coagulation
factor levels with a biologically significant role, but with a poor predictive
value to estimate thrombotic risk beyond established risk factors
FV multiallelic marker detects genetic components of APC resistance contributing to venous thromboembolism in FV Leiden carriers
No full textActivated protein C resistance (APCR) is a major risk factor for venous thromboembolism (VTE). Although the factor V (FV) Leiden mutation accounts for the vast majority of APCR cases, other polymorphisms may contribute to the APCR phenotype. Genetic components of APCR and thrombophilia were investigated by two dinucleotide repeats, characterized in introns 2 and 11 of the FV gene. Only the intron 11 marker was genetically stable and thus suitable for further analysis. Its allelic frequencies were found to differ significantly (P=0.003) between subjects selected for increased APCR in the absence of the FV R506Q mutation (n=70, normalized ratios ≤0.80), and for increased APC sensitivity (n=98, normalized ratios ≥1.31). Genotype differences were also found (P=0.017) between FV R506Q heterozygotes (n=100) who had experienced previous VTE and those (n=100), who were still asymptomatic for VTE. Significance was mostly driven by the relative over-representation of the 12R allele and to a minor extent by the under-representation of the 15R allele among the symptomatic versus the asymptomatic FV Leiden carriers.
Two SNPs (4070A/G and 2391A/G) were found to underlie the 12R and 15R alleles respectively, and marked extended haplo-types, previously (HR2) or newly (HT2) identified. Only the FV HR2 differed (P=0.002) in frequency between the two groups of FV R506Q heterozygotes, suggesting that it represents the most relevant FV genetic component of APCR or VTE detectable by this experimental and clinical approach. Our analysis indicates that frequent FV genetic components might contribute to shape the risk for VTE in FV Leiden carriers
Does factor V Asp79His(409 G/C) polymorphism influence factor V and APC resistence levels?
No full textDoes factor V Asp79His (409 G/C) polymorphism influence factor V and APC resistance levels?
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Incidence of Perfluoroalkyl Substances in Commercial Eggs and Their Impact on Consumer’s Safety
No full textEggs play an important role in a balanced diet; however, the European Food Safety Au-
thority (EFSA) recognizes eggs as a major source of poly and per-fluoroalkyl substances (PFASs).
In this study, the presence of PFASs was analysed in eggs produced by hens from Northern Italian
regions, a PFASs-contaminated area. Sixty-five samples were analysed by high-performance liquid
chromatography coupled with high-resolution mass spectrometry. The greatest presence of PFASs
was found in eggs from Veneto and Emilia Romagna, and the most detected PFASs were perfluorobu-
tanoic acid (PFBA) and perfluorooctanesulfonic acid (PFOS) (mean concentrations 0.30 ± 0.15 and
0.05 ± 0.00 ng g−1) . Considering the most recent updates for the sum of the main four PFASs, the
highest concentration found in the analysed samples was 0.05 ng g−1, well below the maximum limit
set by the European Union. The PFAS intake evaluation confirmed that egg consumption does not
represent a risk for Italian consumers
Two polymorphisms (2120Met/Thr, 2194 Asp/Gly,) in the C2 domain of factor V are associated with reduced factor V levels.
No full textBibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
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