323,112 research outputs found
Cardiovascular diseases in the elderly: possibilities for modulating autophagy using non-coding RNAs
No full textAutophagy is a crucial mechanism implicated in both aging and cardiovascular disease, which are two closely interconnected conditions. Modulation of autophagy is expected to have profound impacts on cellular aging and maintenance of cardiovascular functions under physiological or pathological conditions. Consequently, modulation of autophagy could be an effective strategy for counteracting age-induced vascular and cardiac remodelling as well as alleviating cardiovascular disease. The present review comprehensively elucidates the multifaceted impacts of autophagy on aging of the cardiovascular system. We comprehensively analyse both vascular and cardiac tissues, including vascular and cardiac malignancies, in distinct contexts. We also emphasize the significance of non-coding RNAs (ncRNAs) in the epigenetic regulation of gene expression and their roles as biomarkers of cardiovascular pathologies while maintaining clear distinctions between the vascular and cardiac tissues. Preclinical and clinical models are described herein to highlight the importance of ncRNAs in disease treatment by considering their involvement in the modulation of autophagy within the cardiocirculatory system. Finally, we conducted a comprehensive meta-analysis of transcriptomic data to underscore the paramount importance of autophagy while demonstrating it as a process that is frequently dysregulated in both cardiac and vascular cells under pathological conditions. The findings presented herein emphasize the importance of investigating novel strategies for modulating autophagy as a potential therapeutic approach to the management of age-related cardiovascular disorders
Automated FingerPrint Background removal: FPB
No full textAbstract Background The construction of a whole-genome physical map has been an essential component of numerous genome projects initiated since the inception of the Human Genome Project. Its usefulness has been proved for whole-genome shotgun projects as a post-assembly validation and recently it has also been used in the assembly step to constrain on BACs positions. Fingerprinting is usually the method of choice for construction of physical maps. A clone fingerprint is composed of true peaks representing real fragments and background peaks, mainly composed of E. coli genomic DNA, partial digestions, star activity by-products, and machine background. High-throughput fingerprinting leads to the production of thousands of BAC clone fingerprints per day. That is why background peaks removal has become an important issue and needs to be automatized, especially in capillary electrophoresis based fingerprints. Results At the moment, the only tools available for such a task are GenoProfiler and its descendant FPMiner. The large variation in the quality of fingerprints that is usually present in large fingerprinting projects represents a major difficulty in the correct removal of background peaks that has only been partially addressed by the methods so far adopted that all require a long manual optimization of parameters. Thus, we implemented a new data-independent tool, FPB (FingerPrint Background removal), suitable for large scale projects as well as mapping of few clones. Conclusion FPB is freely available at http://www.appliedgenomics.org/tools.php. FPB was used to remove the background from all fingerprints of three grapevine physical map projects. The first project consists of about 50,000 fingerprints, the second one consists of about 70,000 fingerprints, and the third one consists of about 45,000 fingerprints. In all cases a successful assembly was built.</p
Infrared Optoacoustic Spectroscopy Of 13cd3od Around 9p Co2 Laser Lines
No full textIn this work we present the results of an investigation about Doppler limited infrared absorbing transitions of the in-plane methyl-rocking and the asymmetric methyl deformation modes of 13CD3OD by means of optoacoustic detection. This is an alternative and attractive technique to be applied to this methanol isotopromer, in comparison to Fourier transform spectroscopy. In fact the contamination problem associated with the fast exchange of OD by OH in the molecule limits the use of the Fourier transform technique. Using a waveguide CO2 laser of 290 MHz tunability on each line we were able to observe 20 IR absorptions, most of them of large offset. The data will be useful in theoretical analysis of this molecule, as well as in the generation of FIR laser radiation in optically pumped molecular laser.214621632Borden, A., Baker, F.E., (1939) J.Chem Phys., 6, p. 553Koehler, J.S., Dennison, D.M., (1940) Phys. Rev., 57, p. 1006Pereira, D., Moraes, J.C.S., Telles, E.M., Scalabrin, A., Strumia, F., Moretti, A., Carelli, G., Massa, C.A., (1994) Int. J. of Infrared and Millimeter Waves, 15 (1), p. 1Moruzzi, G., Moraes, J.C.S., Strumia, F., (1992) Int. J. of Infrared and Millimeter Waves, 13 (9), p. 1269Henkel, C., Jacq, T., Nuersberger, R., Menten, K.M., Steppe, H., (1987) Astron. Astrophys., 188 (1), pp. L1Sutton, E.C., Herbst, E., (1988) Astrophys. J., 333 (1), p. 359Moruzzi, G., Strumia, F., Carnesecchi, P., Mukhopadyay, I., Lees, R.M., Johns, J.W.C., (1989) Infrared Phys., 29 (2), p. 583Moruzzi, G., Riminucchi, P., Strumia, F., Carli, B., Carlotti, M., Lees, R.M., Mukhopadyay, I., Winnewisser, M., (1990) J.Mol. Spectrosc., 144 (1), p. 139Moraes, J.C.S., Scalabrin, A., Pereira, D., Dilonardo, G., Fusina, L., (1991) Infrared Phys., 31 (4), p. 365Moraes, J.C.S., Scalabrin, A., Pereira, D., Carelli, G., Ioli, N., Moretti, Strumia, F., (1992) Appl. Phys. B, 54 (1), p. 24Mukhopadyay, I., Lees, R.M., Llewis-Bevan, W., Johns, J.W., (1995) J. Chem. Phys., 102 (16), p. 6444Moraes, J.C.S., Pereira, D., Scalabrin, A., Moruzzi, G., Strumia, F., Winnewisser, B.P., Winnewisser, M., Gupta, P.K., (1995) J. Mol. Spectrosc., 174 (1), p. 177Moraes, J.C.S., Carelli, G., Moretti, A., Moruzzi, G., Strumia, F., (1996) J.Mol. Spectrosc. J. Mol. Spectrosc., 177 (2), p. 302Carelli, G., Ioli, N., Moretti, A., Moruzzi, G., Strumia, F., Zhao, S., Lees, R.M., Goulding, R.R., (1995) Infrared Phys.Tech., 35 (6), p. 743Carelli, G., Moretti, A., Strumia, F., Zhao, S., Lees, R.M., (1996) J. Mol. Spectrosc., 177 (1), p. 79Cruz, F.C., Scalabrin, A., Pereira, D., Vazquez, P.A.M., Hase, Y., Strumia, F., (1992) J. Mol. Spectrosc., 156 (1), p. 22Viscovini, R.C., Scalabrin, A., Pereira, D., (1996) Int. J. of Infrared and Millimeter Waves, 17 (11), p. 1821Carelli, G., Ioli, N., Messina, A., Moretti, A., Strumia, F., Telles, E.M., Moraes, J.C.S., Pereira, D., (1991) Infrared Phys., 31 (4), p. 323Telles, E.M., Moraes, J.C.S., Scalabrin, A., Pereira, D., Carelli, G., Ioli, N., Moretti, A., Strumia, F., (1994) IEEE J. Quantum Electron, QE30 (12), p. 2946Moraes, J.C.S., Telles, E.M., Cruz, F.C., Scalabrin, A., Pereira, D., Carelli, G., Ioli, N., Strumia, F., (1992) Int. J. Infrared and Millimeter Waves, 13 (11), p. 1801Viscovini, R.C., Scalabrin, A., Pereira, D., (1997) IEEE J. Quantum Electron, QE33 (6), p. 916Viscovini, R.C., Telles, E.M., Scalabrin, A., Pereira, D., (1997) Appl. Phys. B, 65 (1), p. 33Viscovini, R.C., Telles, E.M., Scalabrin, A., Pereira, D., (1999) IEEE J. Quantum Electron, QE35 (11), p. 1613Viscovini, R.C., Cruz, F.C., Moraes, J.C.S., Scalabrin, A., Pereira, D., (1999) Int. J. Infrared and Millimeter Waves, 20 (2), p. 193Telles, E.M., Moraes, J.C.S., Scalabrin, A., Pereira, D., Moretti, A., Strumia, F., (1991) Appl. Phys. B, 52 (1), p. 36Pereira, D., Scalabrin, A., (1992) Infrared Phys., 33 (6), p. 549Carelli, G., Ioli, N., Moretti, A., Pereira, D., Strumia, F., (1987) Appl. Phys. B, 44 (2), p. 11
Isothermal VLE measurements for the binary mixtures HFC-125+HFC-245fa and HC-290+HFC-245fa,
No full textThe (P,rho,T) behaviour of 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea) at temperatures between 253 K and 403 K and pressures up to 20 MPa
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Vibrational And Rotational Spectroscopy Of 13cd3od
No full textWe have used Fourier Transform spectral data on the C-O stretching mode of 13CD3OD in order to perform a vibro-rotational analysis for this molecule. We have estimated a few molecular parameters of the ground and C-O stretching vibrational modes. Based on these parameters, and by using the Kwan-Dennison model, we propose assignments for a number of far-infrared laser transitions of 13CD3OD.202193201Moruzzi, G., Winnewisser, B.P., Winnewiesser, M., Mukhopadhyay, I., Strumia, F., (1995) Microwave - Infrared and Laser Transistions of Methanol., , CRC Press, IncMoraes, J.C.S., Pereira, D., Scalabrin, A., Moruzzi, G., Strumia, F., Winnewisser, B.P., Winnewiesser, M., Gupta, P.K., (1995) J. Mol. Spectrosc., 174, p. 177Lees, R.M., Mukhopadhyay, I., Predoi, A., Lewisbevan, W., Johns, J.W.C., (1996) J. Chem. Phys., 105, p. 3406Xu, L.-H., (1994) J. Mol. Spectrosc., 164, p. 287Xu, L.-H., Lees, R.M., Mukhopadhyay, I., Johns, J.W.C., Moruzzi, G., (1993) J. Mol. Spectrosc., 157, p. 447Kwan, Y.Y., Dennison, D.M., (1972) J. Mol. Spectrosc., 43, p. 291Moruzzi, G., Xu, L.-H., Lees, R.M., Winnewisser, B.P., Winnewiesser, M., (1994) J. Mol. Spectrosc., 167, p. 156Viscovini, R.C., Scalabrin, A., Pereira, D., (1996) Int. J. Infrared Millimeter Waves, 17, p. 1821Cruz, F.C., Scalabrin, A., Pereira, D., Vazquez, P.A.M., Hase, Y., Strumia, F., (1992) J. Mol. Spectrosc., 156, p. 22Mukhopadhyay, I., (1997) Spectroc. Acta A, 53, p. 979Jackson, M., Sudhakaran, G.R., Gansen, E., (1996) J. Mol. Spectrosc., 176, p. 439Moraes, J.C.S., Scalabrin, A., Pereira, D., Di Leonardo, G., Fusina, L., (1991) Infr. Phys., 31, p. 365Walker, S., Straw, H., (1970) Spectroscopy, , Chapman & Hall, LondonLees, R.M., Baker, J.G., (1968) J. Chem. Phys., 48, p. 5299Lees, R.M., (1972) J. Chem. Phys., 56, p. 5887Viscovini, R.C., Telles, E.M., Scalabrin, A., Pereira, D., (1997) Appl. Phys. B, 65, p. 33Viscovini, R.C., Scalabrin, A., Pereira, D., (1997) IEEE J. Quantum Electron., 33, p. 91
Development of a fundamental equation of state for the liquid region of a pure fluid from speed of sound measurements. Application to water.
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