1,720,972 research outputs found
Utilizzo del sistema informativo delle schede di dimissione ospedaliera per l’individuazione di possibili tumori di origine professionale.
No full textsistema informativo - schede di dimissione ospedaliera - possibili tumori di origine professional
Oncologic Outcome and Continence Recovery after Laparoscopic Radical Prostatectomy: 3 Years' Follow-Up in a "Second Generation Center"
No full textObjectiues: Laparoscopic radical prostatectomy in major centers guarantees oncologic and functional results equal to open procedures. In our institution this operation was introduced in 2001 after an adequate training in laparoscopic surgery. We report the oncologic and functional results after 3 years of experience.Methods: We considered our first 150 patients that had undergone transperitoneal laparoscopic radical prostatectomy. The following parameters were prospectively collected and analyzed: pathological findings, surgical margins, surgical time, blood loss, hospital stay, catheterization, complications, oncologic follow-up and continence.Results: Single positive surgical margins were observed in 26 patients (17.3%) and multiple positive margins in 15 patients (10%). The rates of positive margins in organ confined tumors (pT2a/b) were 11.3%. Preoperative PSA > 10 ng/ml (Chi-square p < 0.01), pathological stage > pT2 (Chi-square p < 0.001) and Gleason score > 6 (Chi-square p < 0.01) were significantly correlated with positive margins. Major complications occurred in 16 patients (10.7%). The total recurrence rate is 11.7%. The continence rate at 12 months is 91.7%. with 44.3% of patients completely continent at the moment of catheter removal.Conclusions: Laparoscopic radical prostatectomy in now a well codified operation that, after an adequate training, could be learned and reproduced safely. Actually this is our first choice surgical approach in patients with localized prostate cancer. (c) 2006 Elsevier B.V. All rights reserved
Data-driven modelling and optimal management of district heating networks
No full textThis paper presents an optimization-based algorithm for the management of district heating networks, aiming to minimize their operational cost and maximize their efficiency. The method involves a mixed-integer formulation to properly control the operations of gas boilers and cogeneration systems at the central heating station. A novel modelling method for the district heating networks is also proposed, where temperature dynamics are directly learned from data through the identification of piece-wise affine models. The developed approach ensures that proper temperature levels are always provided to all users, meanwhile minimizing the network heat losses, and enabling cogeneration systems to optimally participate to the Day-Ahead Energy Market. The optimization system has been designed considering a real district heating network in the Milan area and first experiments on the real plant have been carried out. The economic evaluations are satisfactory, leading to significative energy saving and a consistent reduction of CO2 emissions and gas consumption
[Study of lung cancer risk in the electroplating industry in Lombardy based on the OCCAM method].
No full textLa metodologia OCCAM consiste nello studio dei rischi professionali di tumore per area e comparto produttivo con
un disegno di tipo caso-controllo, utilizzando le informazioni degli archivi correnti per l’identificazione dei casi e
dei controlli e per l’attribuzione delle esposizioni. OCCAM assegna come esposizione a ciascun soggetto il codice di comparto produttivo dove abbia lavorato per la maggiore quantità di tempo. La categoria dei “non esposti” è costituita
dai lavoratori del terziario. Il comparto produttivo, a sua volta, è determinato dal codice di attività economica
ATECO attribuito da INPS a ciascuna azienda ove abbia lavorato il soggetto. In questo lavoro le aziende di lavorazione
galvanica della Lombardia sono state ricercate mediante la descrizione in chiaro della attività produttiva,
anch’essa presente negli archivi INPS, nell’intento di ottenere una maggiore sensibilità e specificità rispetto al settore
“trattamento metalli” previsto dal codice ATECO pure fornito da INPS. Sono stati considerati i casi incidenti di
tumore del polmone nel periodo 2001-2008 residenti in Lombardia identificati mediante le schede di dimissione
ospedaliera. Con questa riclassificazione il rischio di tumore del polmone negli addetti alla lavorazione galvanica è
passato nei maschi da 1.32 (90% CI 1,06-1,64, 67 casi), relativo a “trattamento metalli” a 2.03 (90% CI 1,33-
3,10, 18 casi) nelle industrie galvaniche e nelle femmine da 1.33 (90% CI 0.51-3.59, 10 casi) a 3.00 (90% CI
1,38-9,03, 4 casi). Il miglioramento della classificazione ha prodotto una stima superiore del rischio, anche se basata
su di un numero inferiore di casi. Pur trattandosi di rischi dovuti ad esposizioni del passato, la storia di alcuni
casi e l’avere osservato casi recenti di perforazione del setto nasale in lavoratori delle galvaniche indicano che, almeno
in alcune aziende, ancora oggi vi possano essere situazioni di rischio
Female breast cancer in Lombardy, Italy (2002-2009): A case-control study on occupational risks.
No full textAbstract
BACKGROUND:
The role of occupational exposures in breast cancer development is still uncertain and, to our knowledge, no studies have been recently carried out in Italy to provide a comprehensive estimation of this possible risk.
METHODS:
Based on administrative data, a case-control study was carried out recruiting all incident cases of female breast cancer in the period 2002-2009, aged between 35 and 69 years, residing in Lombardy, Italy. Controls were randomly sampled from all women residing in Lombardy as of December 31, 2005. Occupational histories, including blue-collar status, were available from 1974 through record linkage with a social security pension database, and were obtained for 11,188 cases and 25,329 controls. Adjusted odds ratios (ORs) and corresponding 90% confidence intervals (CIs) were calculated using multiple unconditional logistic regression models, including terms for sectors of longest employment and for duration of employment. Multiple comparisons were accounted for according to the Benjamini-Hochberg method.
RESULTS:
The ORs for female breast cancer were modestly but significantly increased for employment in electrical manufacturing (OR 1.12, 90%CI 1.04-1.21), textile (OR 1.08, 90%CI 1.02-1.15), paper (OR 1.25, 90%CI 1.06-1.46) and rubber (OR 1.26, 90%CI 1.03-1.54) industries. Analysis by duration of employment within sectors showed significantly increased ORs for electrical manufacturing and rubber industries. After adjustment for multiple comparisons no estimates remained statistically significant.
CONCLUSIONS:
Although with several limitations, our results point to a possible role of exposures in electrical manufacturing, textile, paper and rubber industries in the process leading to breast cancer. An in-dept study for the electrical manufacturing industry has been already planned. Am. J. Ind. Med. 2013. © 2013 Wiley Periodicals, Inc
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
[Female breast cancer and occupational sectors: a preliminary study in the provinces of Lombardy, Italy].
No full textBackground. The role of occupational exposures in
breast cancer development is still uncertain. A recent paper
showed increased risks in some occupational sectors in
Lombardy, Italy. We deepened this analysis at the level of singleprovinces of the same Italian region.
Methods. Based on administrative data, a case-control study was
carried out recruiting all incident cases of female breast cancer in the period 2002-2009, aged between 35 and 69 years, residing in Lombardy, Italy. Controls were randomly sampled from all women residing in Lombardy as of December 31, 2005.
Occupational histories, including blue collar status, were
available from 1974 through record linkage with a social security
pension database, and were obtained for 11188 cases and 25329 controls. Adjusted odds ratios (ORs) and corresponding 90% confidence intervals (CIs) were calculated using multiple
unconditional logistic regression models. Analyses were
performed also by single provinces of Lombardy, Italy.
Multiple comparisons were accounted for according to the
Benjamini-Hochberg method.
Results. The ORs for female breast cancer were modestly
but significantly increased for employment in electrical
manufacturing (OR 1.12, 90% CI 1.04-1.21), textile (OR 1.08,
90% CI 1.02-1.15), paper (OR 1.25, 90% CI 1.06-1.46) and rubber
(OR 1.26, 90% CI 1.03-1.54) industries. Analysis by province
showed significantly increased ORs for electrical manufacturing
in the Milano province. After adjustment for multiple
comparisons no estimates remained statistically significant,
except OR for electrical manufacturing in the Milano province.
Conclusions. Although with several limitations, our results point
to a possible role of exposures in electrical manufacturing,
textile, paper and rubber industries in the process leading to
breast cancer. An in-dept study for the electrical manufacturing industry has been already planned in Milano province
Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case-Control Study.
Full text linkBackground: A previous explorative record-linkage study suggested a putative role of employment in electrical manufacturing in increasing female breast cancer risk in the Province of Milan (Italy). We deepened the understanding of this possible association in a single large electrical manufacturing plant located in Lombardy in the Province of Milan. Methods: We carried out a nested case-control study within a cohort of women employed in a large electrical manufacturing plant. All incident cases during 2002 to 2009 of female breast cancer in individuals who worked at least a 1 year in the factory and resided in Lombardy, Italy, were selected. Controls were randomly sampled from all women who worked in the same plant and resided in Lombardy as of December 31, 2005. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated using multiple logistic regression models, taking into consideration only female workers as ever/never exposed to physical/chemical agents and their longest occupational period. ORs were adjusted for several potential confounders, namely, other known risk factors. Results: The ORs for female breast cancer were significantly increased for exposure to chlorinated solvents (OR 1.65, 95% CI 1.04−2.62), and there was a twofold increase (OR 2.10, 95% CI 1.21−3.66) among women exposed for at least 10 years. We found no other significantly increased OR by exposure or job title
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