262,199 research outputs found
Correction: Semantic Evaluation of Nursing Assessment Scales Translations by ChatGPT 4.0: A Lexicometric Analysis (Nursing Reports, (2025), 15, 6, (211), 10.3390/nursrep15060211)
No full text: Elena Sblendorio was not included as an author in the original publication [...]
Gli epigrammi funerari del sepolcreto dei Fadieni (Gambulaga) e i carmi epigrafici del Ferrarese
No full text
I Carmina Latina Epigraphica non-buecheleriani delle province africane. Introduzione al tema, materiali preparatori,edizione di testi, aspetti e problemi
No full textIl volume fornisce una sintesi dei principali aspetti problematici dei carmi latini epigrafici rinvenuti nelle province africane, un complesso imponente di circa 600 testi, che di per sé fornisce documento efficace dell’importanza di tali province nell’assetto dell’Impero. Esame di temi ricorrenti, esegesi di singoli carmi particolarmente significativi o di blocchi unitari di carmi, indagine su elementi compositivi, per esempio l’acrostico, sono questi alcuni dei punti toccati. Cura particolare viene posta nell’indagine sulla distribuzione geografica dei carmi africani (cui corrisponde una distribuzione della ‘cultura’ latina dell’area africana), sugli aspetti sociali e, più ancora, su quelli linguistici e metrici dei testi
Duchenne muscular dystrophy: rational basis, state of the art
No full textAbstract
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease that affects approximately 1 in 3500 male births. Boys with Duchenne have a progressive and predictable muscle deterioration: muscles lack dystrophin, a protein essential for membrane stability, whose absence induces contraction-related membrane damage and activation of the inflammatory cascade leading to muscle failure, necrosis, fibrosis. Although DMD is present at birth, clinical symptoms are not evident until 2-6 years of age. Initial symptoms include leg weakness, increasing spine kyphosis, and a waddle-like gait. Continuous muscle wasting leads to progressively weaker muscles, usually leading DMD patients on wheelchair by the age of 8-12. Scoliosis develops in 90% of boys who use a wheelchair full-time. Progression of muscle degeneration and worsening clinical symptoms lead to death in the late twenties from respiratory/cardiac failure
Gli epigrammi funerari del sepolcreto dei Fadieni (Gambulaga) e i carmi epigrafici del Ferrarese
No full textEsame filologico di una serie di epigrammi funerari rinvenuti in un sepolcreto prediale della zona di Ferrar
Pharmacokinetic evaluation of bazedoxifene for the treatment of osteoporosis.
No full textINTRODUCTION:Bazedoxifene is a third-generation Selective Estrogen Receptor Modulator, developed on raloxifene's model, and investigated as treatment for postmenopausal osteoporosis and menopause management. Clinical trial have shown that bazedoxifene is effective as raloxifene in preventing bone loss in women at risk of osteoporosis and that in patients with osteoporosis it is effective in reducing the incidence of new vertebral fracture with a protection maintained for up 7 years.AREAS COVERED:This drug evaluation presents the antifracture efficacy of bazedoxifine and evidence that it, unlike raloxifene, can reduce the rate of non-vertebral fractures in high-risk patients. The authors also review the effects of bazedoxifine has on reproduction tissues as well as the on lipid pattern. Additionally, the authors present the safety profile of bazedoxifine and discuss its prospects, specifically in relation to conjugated estrogen.EXPERT OPINION:Despite its peculiar profile, bazedoxifene could be considered as a second-line therapy for women < 65 - 70 years of age, where bisphopshonates are contraindicated or not well tolerated. Furthermore, the authors believe that bazedoxifene could also have its place as a first-line therapy for younger postmenopausal patients in the management of menopause and prevention of osteoporosis; this could be prescribed either by itself or in combination with conjugated estrogen. The authors also highlight the fact that the association of bazedoxifene and conjugated estrogen could also be beneficial in the treatment of climacteric syndrome in patients with menopausal symptoms
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