461 research outputs found
The effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination
No full textPlanar cell polarity (PCP) is known as the polarization of cells within the plane of the tissue layer. This form of polarization controls several epithelial and non-epithelial morphological processes, such as the orientation of primary cilia in the inner ear, convergent extension (CE) and directed migration. A three tiered model of PCP regulation has been proposed which consists of the global, core, and effector modules. However there is one addition level of modulation through non-canonical Wnt signaling pathway. Of the many Wnt proteins a few have been identified to signal primarily through this pathway. One such protein is Wnt5a, which has been shown to modulate PCP during directed cell migration. In this study we gather preliminary data for the presence of PCP signaling components in Schwann cells and investigate the effect of Wnt5a and its antagonist Wnt3a on Schwann cell proliferation, migration and myelination.M.S.Includes bibliographical referencesby Neha Jan
The effects of immediate versus delayed feedback after multiple-choice questions on subsequent exam performance
No full textThis thesis investigates the effects of immediate versus delayed feedback following multiple-choice questions on subsequent performance on multiple-choice and recall questions. In three experiments, students in a college psychology lecture course received immediate or delayed feedback following multiple-choice questions on an initial unit exam which was followed up with exam(s) including both multiple-choice and short-answer questions. In the first experiment, the kind of feedback did not affect performance on the same multiple-choice questions when they were repeated on the final. In the second experiment, two subsequent follow-up exams included first a short-answer version of the multiple-choice question and then the same multiple-choice question. Performance on the short-answer questions was better following delayed feedback than following immediate feedback. However, the kind of feedback had no effect on the performance of the repeated multiple-choice questions. Also, the interval between the initial exam and the follow-up exam had no effect on performance. The third experiment examined whether delayed feedback increased confidence more than immediate feedback and whether the increase in confidence mediated the improved performance on subsequent short-answer questions. The delayed feedback had no effect on confidence for the subsequent short-answer and multiple-choice responses. Together, these results demonstrate that delayed feedback improves performance on the short-answer questions by increasing the subsequent generation of the correct response but does not influence recognition of it.M.S.Includes bibliographical referencesIncludes vitaby Neha Sinh
Moral Panic, Social Exclusion and The Human Rights of Same-Sex Partners in Ghana-RETRACTED
No full textThis article is retracted :
The retraction is based on the request of the author, Dr. Neha Jain, as it contains some exclusive and private data of a community out of India, that should not be released online. https://doi.org/10.55938/ijgasr.v1i3.20
Sincerely,Editorial Team, IJGASR
Announcement: https://journals.icapsr.com/index.php/ijgasr/announcement/view/17
Fused deep learning paradigm for the prediction of o6-methylguanine-DNA methyltransferase genotype in glioblastoma patients: A neuro-oncological investigation
No full textBackground: The O6-methylguanine-DNA methyltransferase (MGMT) is a deoxyribonucleic acid (DNA) repairing enzyme that has been established as an essential clinical brain tumor biomarker for Glioblastoma Multiforme (GBM). Knowing the status of MGMT methylation biomarkers using multi-parametric MRI (mp-MRI) helps neuro-oncologists to analyze GBM and its treatment plan. Method: The hand-crafted radiomics feature extraction of GBM's subregions, such as edema(ED), tumor core (TC), and enhancing tumor (ET) in the machine learning (ML) framework, was investigated using support vector machine(SVM), K-Nearest Neighbours (KNN), random forest (RF), LightGBM, and extreme gradient boosting (XGB). For tissue-level analysis of the promotor genes in GBM, we used the deep residual neural network (ResNet-18) with 3D architecture, followed by EfficientNet-based investigation for variants as B0 and B1. Lastly, we analyzed the fused deep learning (FDL) framework that combines ML and DL frameworks. Result: Structural mp-MRI consisting of T1, T2, FLAIR, and T1GD having a size of 400 and 185 patients, respectively, for discovery and replication cohorts. Using the CV protocol in the ResNet-3D framework, MGMT methylation status prediction in mp-MRI gave the AUC of 0.753 (p < 0.0001) and 0.72 (p < 0.0001) for the discovery and replication cohort, respectively. We presented that the FDL is ∼7% superior to solo DL and ∼15% to solo ML. Conclusion: The proposed study aims to provide solutions for building an efficient predictive model of MGMT for GBM patients using deep radiomics features obtained from mp-MRI with the end-to-end ResNet-18 3D and FDL imaging signatures
Correction to: A cell-cycle signature classifier for pan-cancer analysis
No full textIn the original published version, the list of authors was incomplete. Theodora A. Constantin was missing, and Neha Tabassum and Theodora A. Constantin share first authorship. The correct author list is given above. The original article has been corrected. DOI to original article: https://doi.org/10.1038/s41388-020-01426-
Less-institutionalized social structures: a theoretical, methodological, and empirical analysis of how networks and culture matter for emergence
No full textUsing a networks and culture lens, I investigate the micro-level processes underlying the production of order in social contexts or locations that are relationally-defined and meaningful, but lack cultural cues to action and interpretation or are in the early stages of acquiring such meaning. Drawing on neoinstitutionalist theory, I refer to such social structures as less-institutionalized. To explain order in the absence of situational cultural cues literature in social network analysis has traditionally attributed regularities to situational structural tendencies that preclude shared understandings and/or subjective engagement. Recent literature in the sociology of culture that revives overarching moral intuitions as a basis for action similarly rejects the explanatory value of situational cultural cues. Arguing that culture is neither irrelevant nor implicated in an overarching way in culturally less-institutionalized situations, I posit that order can be linked to individuals’ tacit and discursive use of cultural repertoires acquired over the life-course through involvements in multiple networks of interaction and domains of shared meanings or ‘netdoms.’ I analytically distinguish between three categories of less-institutionalized situations of the basis of the degree of uncertainty in interpretation and action they impose upon their occupants: high, intermediate, and absence/low. I demonstrate my argument using three examples of less-institutionalized situations/positions from distinct sociological fields: (1) rapid labor-force feminization in South Asia (high-uncertainty); (2) an emergent area of knowledge production (intermediate-uncertainty); and (3) falling average sibship-size implicated in worldwide fertility decline (low/absent uncertainty). Elaborating upon three cross-netdom mechanisms - analogizing, contrasting, and spillovers – and using a mixture of interpretive techniques, multilevel statistical models, and exponential random graph models, I show that occupants use cultural repertoires discursively in high-uncertainty less-institutionalized positions, tacitly in low-uncertainty situations, and in a combination of tacit and deliberative ways under conditions of intermediate uncertainty. I also develop a mathematical model to show how less-institutionalized practices/interpretations can come to be institutionalized over time through management of uncertainty within homophilous networks. Lastly, positing a duality between the cultural repertoires of individuals and those of social locations, I conclude with a discussion on how less-institutionalized positions offer a unique window into investigating processes of emergence and social change.Ph. D.Includes bibliographical referencesIncludes vitaby Neha Gonda
STUDY OF PLANT GROWTH & SOIL POLLUTION BY MARBLE SLURRY
No full textMakrana is a biggest Marble cluster of India. In the present study marble industries soil pollution by marble slurry was taken from the industrial site situated in Makrana. Soil texture is determined by the size of constituent particles which have been named differently by the international society of soil science. From these industries slurry powder is come out from the earth and mixed with soil. Slowly soils upper strata become destroy from this slurry
Isolation and Characterization of Xanthine Oxidase Inhibitor(s) from Endophytic Fungi
No full textThe present study was oriented towards the exploration of xanthine oxidase inhibitory potential of fungal endophytes isolated from Indian medicinal plants inhabiting biodiversity hotspots of India. Of 181 endophytic isolates, culture filtrates of 38 isolates were found to exhibit XO inhibitory activity over xanthine-NBT agar plate preliminary assay. Both the quantitative assays indicated ten fungal isolates to be potent producers of xanthine oxidase inhibitory entities. The crude chloroform residue of endophytic fungal isolate, #1 CCSTITD was found to be non-purine in nature and exhibited maximum XO inhibitory activity with IC50 of 0.54 μg/ml which was better than positive control Allopurinol (IC50- 0.93 μg/ml). The potential endophytic fungus was identified using morphological and molecular tools as novel Muscodor species named as Muscodor darjeelingensis. Further, the crude chloroform residue of M. darjeelingensis was fractionated into 18 major fractions using TLC and column chromatography.
The fraction 9 was found to exhibit mixed type XO inhibitory potential with Ki value of 17.54 μM which was quite close to the febuxostat (Ki- 14.5 μM). The fraction 9 was pale yellow in color, light sensitive, slightly polar having a melting point >200 ˚C. H1-NMR and C13-NMR spectra of bioactive fraction 9 suggested it to be a long chain unsaturated, hydroxylated terpenoid. Further, IR spectra confirmed the presence of carboxyl group. Mass spectra of bioactive fraction showed parent ion peak at m/z 569 and molecular ion peak at m/z 553. The NMR, IR and ESI-MS spectral data of bioactive fraction 9 was found to be identical to that of dihydroxy-carotenoid Lutein. Hence, the bioactive fraction was proposed to be Lutein. This is the first report of a plant carotenoid being produced by an endophytic fungus which is also a potent XO inhibitor. The present study establishes that endophytic fungi are prolific sources of novel non-purine selective inhibitors of xanthine oxidase (NP-SIXO’s). The isolation of Lutein, as XO inhibitor from endophytic fungi further warrants its further evaluation by in silico docking studies and optimizing using QSAR (Quantitative Structure Activity Relationship) for its development into a pharmacophore in management of long term hyperuricemia and oxidative stress related diseases since lutein is already being used as a nutraceuticals
Water Quality Analysis of near Marble Mine Area in Tehsil -Kotputali, District- Jaipur, Rajasthan (India)
No full textWater is the most vital resources in our planet. From the different mining process the quality of ground water and surface water get contaminated by chemicals from mining. Further in processes creating environmental damage, the contamination resulting from leakage of chemicals also affects the health of the local population. To assess the quality of water two monitoring/sampling summer seasons were selected to analyses the quality of water near the marble mine in Tehsil - Kotputali, District- Jaipur (Rajasthan). Result shows that mining affects the quality of surrounding surface water and ground water. Observation showed a negative correlation with the water control. 20% results are within the permissible limits but 80 % results are above the permissible limits recommended by IS:3025 & APHA. The water is contaminated with high concentration of metals, types of toxic sulphides, and the presence of salts can negatively affect the water quality, marine life and ground water quality. Keyword: Mining, Sulphides, Toxic, Jaipur
Competing bimetallic ratios: Amsterdam, London and bullion arbitrage in the 18th century
No full textThis article analyses the stability of bimetallism in the mid-18th century for the case of two large centres that had different legal ratios and only one international market ratio. A new theoretical framework is articulated for the situation of international independence to set legal bimetallic ratios by monetary authorities in different countries. Then, using new data handcollected from archival sources and relevant to the two main bullion markets in the 18th century, Amsterdam and London, this theoretical framework is utilised to identify the regimes that actually prevailed during that period, in which Amsterdam was effectively on the bimetallic standard while London was on the gold standard de facto.Bimetallism, Bimetallic stability, Bullion markets, Arbitrage, Specie-point mechanism, Melting-minting points
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