1,721,083 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Eosinophilic fasciitis leading to painless contractures
No full textWe report on an 11-year-old girl who developed multiple joint contractures over a period of 3 months. The disease presented with progressive involvement of the fingers, elbows, shoulders, knees and feet and was not accompanied by other symptoms. Laboratory investigations showed eosinophilia and hypergammaglobulinaemia. Muscle ultrasound and magnetic resonance imaging of the right forearm revealed thickened fascia and a full thickness biopsy confirmed the diagnosis of eosinophilic fasciitis. Following treatment with pulsed steroids, the contractures resolved. Conclusion: our case shows that eosinophilic fasciitis can present without skin involvement and arthritis and therefore has to be regarded as a differential diagnosis of contractures in childhood. Pulsed steroid treatment was effective and without side-effects
A comparative approach to confirm antibiotic-resistant microbes in the cryosphere
Full text linkAntibiotic-resistant microbes pose one of the biggest challenges of the current century. While areas with proximity to human impact are closely studied, a lot is yet to learn about antimicrobial resistance in remote regions like the cryosphere. Nowadays, antibiotic (AB) resistance is considered a pollution that has reached the Earth’s most pristine areas. However, monitoring of resistant environmental bacteria therein faces several challenges that inhibit scientific progress in this field. Due to many cultivation-based antibiotic susceptibility tests being optimized for mesophilic pathogenic microorganisms, many researchers opt for expensive molecular biological approaches to detect antibiotic resistance in the cryosphere. However, some disadvantages of these methods prohibit effective comprehensive monitoring of resistant bacteria in pristine areas, hence we suggest established cultivation-based approaches when looking for antimicrobial resistance in the cryosphere. In this study, we compared two common antibiotic susceptibility tests and optimized them to meet the needs of psychrophilic microorganisms. The resulting cultures thereof originated from cryospheric habitats with differing anthropogenic impacts. The results show that these methods are applicable to detect antibiotic resistance in cryospheric habitats and could potentially increase the comparability between studies
Ultrastructural evaluation of pig retinal pigment epithelium susceptibility to variable durations of hypoxia.
No full textTwo brothers with Hennekam syndrome and cerebral abnormalities
No full textWe report two brothers with mental retardation, lymphoedema of the limbs and facial anomalies. Hennekam et al. (Am J Med Genet 34:593-600; 1989) described four patients with identical signs and intestinal lymphangiectasia. To confirm the diagnosis of Hennekam syndrome we undertook a duodenal biopsy from the older brother which revealed intestinal lymphangiectasia. So far only one patient with Hennekam syndrome and cerebral abnormalities has been described. This patient presented with pachygyria in the parietal area. Cerebral MRI in our two cases revealed small subcortical hyperintensities in both patients and a large cystic lesion in the younger patient probably representing an old media infarction. Clin Dysmorphol 9:21-24 (C) 2000 Lippincott Williams & Wilkins
Ultrastructural evaluation of pig retinal pigment epithelium susceptibility to variable durations of hypoxia.
No full textApplication of new ploidy-related parameters for the diagnosis of ovarian tumours
No full textDifferential diagnostics of borderline ovarian tumours and ovarian carcinomas is generally based oil morphological criteria, which are not always sufficient for filial diagnosis. Therefore, we investigated the practical diagnostic application of the CAS200 image analyzer and new ploidy-related parameters in a series of 68 borderline tumours and 42 low-grade carcinomas of the ovary. Highly significant differences between borderline and malignant lesions were found for the percentage of diploid cells (p=0.0001), the percentage of aneuploid cells between 4c and 8c (p=0.0001), the percentage of octaploid cells (p=0.0001), as well as for the 5c exceeding late (p=0.0001). The difference concerning the ratio of tetraploid cells also reached the level of significance (p=0.0320). We suggest that new ploidy-related parameters evaluated by the CAS200 image analyzer can be helpful in ovarian lesions with unclear morphology
Application of new ploidy-related parameters for the diagnosis of ovarian tumours
No full textDifferential diagnostics of borderline ovarian tumours and ovarian carcinomas is generally based oil morphological criteria, which are not always sufficient for filial diagnosis. Therefore, we investigated the practical diagnostic application of the CAS200 image analyzer and new ploidy-related parameters in a series of 68 borderline tumours and 42 low-grade carcinomas of the ovary. Highly significant differences between borderline and malignant lesions were found for the percentage of diploid cells (p=0.0001), the percentage of aneuploid cells between 4c and 8c (p=0.0001), the percentage of octaploid cells (p=0.0001), as well as for the 5c exceeding late (p=0.0001). The difference concerning the ratio of tetraploid cells also reached the level of significance (p=0.0320). We suggest that new ploidy-related parameters evaluated by the CAS200 image analyzer can be helpful in ovarian lesions with unclear morphology
- …
