649 research outputs found
Agalope liuzihaoi Huang, Horie, Fan, Wang & Espeland, 2023, sp. n.
No full text<i>Agalope liuzihaoi</i> S.-Y. Huang & Horie sp. n. <p>(Figs 14, 54, 73)</p> <p> <b>Type material.</b> <b>Holotype:</b> male, hindwritten label (in Chinese) “ 2017. 8. 13, LZH, <b>AENJffiṄDZ</b> ”(2017. 8. 13 (13. VIII. 2017), Bomi, Zhagang Town (Gang Village, Zhamu Town, Bomi County, Xizang Autonomous Region), LZH (leg. Zi-hao Liu))/ hindwritten label“ZSY183” (CHSY, will be subsequently deposited in ZFMK).</p> <p> <b>Diagnosis.</b> Length of forewing 21 mm in male. Externally <i>A. liuzihaoi</i> <b>sp. n.</b> is only reminiscent of <i>A. geoffi</i> <b>sp. n.</b> described above, but it can be distinguished from the latter by the combination of the following characters: 1) Both wings broader. 2) On the hindwing the cilia are white thoroughly from apex to tornus, while in <i>A. geoffi</i> <b>sp. n.</b> the cilia are greyish from apex to cell Cu 2 and white from cell Cu 2 to the tornus. 3) The posterior tegumenal projection is slightly longer. 4) The distal saccular process is significantly long and slender, while in <i>A. geoffi</i> <b>sp. n.</b> it is much shorter and forms a triangular process pointed upwards. 5) The phallus is somewhat longer.</p> <p> <b>Distribution.</b> Known from Bomi County in southeastern Xizang, China, its type locality.</p> <p> <b>Etymology.</b> The specific epithet <i>liuzihaoi</i> is dedicated to the collector of the new species, Dr. Zi-hao Liu, a good friend of the first author. A noun in the genitive case.</p>Published as part of <i>Huang, Si-Yao, Horie, Kiyoshi, Fan, Xiao-Ling, Wang, Min & Espeland, Marianne, 2023, A review of the genus Agalope Walker (Lepidoptera, Zygaenidae, Chalcosiinae) with taxonomic notes and descriptions of three new genera and three new species, pp. 291-321 in Zootaxa 5284 (2)</i> on page 297, DOI: 10.11646/zootaxa.5284.2.4, <a href="http://zenodo.org/record/7923410">http://zenodo.org/record/7923410</a>
Abstract 3611: Proteasome subunit PSMD1 participates in p53 degradation and regulates proliferation of breast cancer cells
No full textAbstract
Breast cancer is the most common cancer among women in developed countries. Generally, 70% of primary breast cancer patients express estrogen receptor, thus endocrine therapy is often efficient for the disease using antiestrogen such as tamoxifen as well as aromatase inhibitor. During long-term therapy, however, a substantial proportion of women recurrent and acquire resistance to endocrine therapy. Understanding of the mechanism underlying acquired endocrine resistance would be a first step toward overcoming hormone-refractory cancer. In this study, we identified candidate genes that contributed to tamoxifen resistance in MCF-7 breast cancer cells by functional screening based on short hairpin RNA (shRNA) library. We found that several candidate genes were overexpressed in breast cancer patients and their abundance was positively associated with poor prognosis of cancer patients in clinical database. Moreover, the genes associated with poor prognosis also showed positive association with shorter survival for patients treated with tamoxifen. Expression levels of these candidate genes were upregulated in hydroxytamoxifen (OHT)-resistant MCF-7 cells (OHTR) compared with parental cells. Proliferation of OHTR cells was repressed by siRNAs targeting 26S subunits, non-ATPase 1 (PSMD1) and tetraspanin12 (TSPAN12). Furthermore, knockdown of PSMD1 inhibited cell cycle progression and p53 protein degradation. p21 and 14-3-3σ, target genes of p53, were upregulated by PSMD1 knockdown. These findings would be used for the development of alternative diagnostic and therapeutic options for endocrine-resistant breast cancers.
Citation Format: Toshiyuki Okumura, Kazuhiro Ikeda, Wataru Sato, Kuniko Horie-Inoue, Satoshi Inoue, Satoru Takeda, Koji Okamoto. Proteasome subunit PSMD1 participates in p53 degradation and regulates proliferation of breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3611. doi:10.1158/1538-7445.AM2017-3611</jats:p
Toucher les souffles marginaux : réflexions sur quelques reflets de la banlieue parisienne au Japon
No full textCet article vise à montrer comment les Japonais ont observé la banlieue de France au cours des trente dernières années. Il vise également à examiner comment ils ont « traduit » la banlieue, c’est-à-dire comment ils l’ont rendue compréhensible au-delà de sa surface médiatisée, en recourant à la littérature. La littérature japonaise a découvert de nouvelles valeurs dans la banlieue de Tokyo à travers la traduction des littératures occidentales : la banlieue représente un lieu de promenade inspiré par Tourgueniev et basé sur une nouvelle sensibilité envers la nature, ou encore le lieu où les enfants de la classe moyenne sont entourés de soins familiaux, comme le raconte la littérature anglaise pour enfants. Les traductrices japonaises de la littérature de banlieue française tentent de présenter les souffles des personnes qui y vivent, que les recherches scientifiques ou les médias ne sauraient saisir, mais elles ne peuvent s’empêcher, par ailleurs, d’insérer des notes dans leurs traductions pour aider les lecteurs à comprendre le contexte sociologique des oeuvres. À titre d’exemple, Vers la banlieue (1995) d’Horie Toshiyuki est conçu, selon l’auteur, pour représenter la « position » de la banlieue parisienne, tandis que la traduction du roman Le petit Malik de Mabrouck Rachedi (2008) est réalisée pour transmettre les voix de la banlieue. Rachedi aborde pleinement les conditions socioculturelles de la banlieue dans son ouvrage et cette tendance est accentuée par l’apparat de notes dans la traduction. Horie, en revanche, laisse de côté la situation sociologique en traduisant la banlieue de Paris dans les impressions de paysages procurées par les détours livresques. La banlieue reste ainsi un lieu en devenir, où les promeneurs s’égarent en rêveries, et la traduction est un lieu de partage où le sens est suspendu et remis en question.This article aims to show how the Japanese have observed the suburbs of France for thirty years, and examine how they “translated” the suburbs, that is to say how they made it understandable beyond its reported surface, by resorting to literature. Japanese literature discovered new values in the suburbs of Tokyo brought by the translation of Western literatures: the wood-walk is inspired by Turgenev and based on a new sensitivity towards nature, and the middle-class children are surrounded by care in the family as told in English children’s literature. Currently, Japanese translators of the French suburbs’ literature are trying, on the one hand, to present the breath of people living there that scientific research as media cannot grasp, but they cannot shirk, on the other hand, to use notes to help readers understand the sociological context of the works. Towards the suburbs (1995) of Horie Toshiyuki is conceived, according to the author, to represent the “position” of the Parisian suburbs, while the translation of Lepetit Malik by Mabrouck Rachedi (2008) is made to convey the voices of the suburbs. Rachedi fully brings the sociocultural conditions of the suburbs in his book and this trend is accentuated by the annotated translation. Horie, on the other hand, drops the sociological situation by translating the suburbs of Paris into the impressions of landscapes procured by the bookish detours. The suburb thus remains a place in the making, where the walkers are wandering in daydreams, and the translation is a common place where the meaning is suspended and questioned
Chalcosia hyalina Kollar 1844
No full textThe <i>hyalina</i> species-group <p> <b>Diagnosis.</b> The <i>hyalina</i> species-group can be distinguished from <i>eronioides</i>, <i>livida</i> and <i>geoffi</i> species-groups by the combination of the following characters: 1) Relatively smaller, similar to the size of the <i>geoffi</i> species-group, while members of the <i>eronioides</i> species-group and the <i>livida</i> species-group are larger. 2) Forewing with a pale spot in cell R 4, similar to that of the <i>eronioides</i> and <i>livida</i> species-groups, while such spot is absent in the <i>geoffi</i> species-group. 3) 8th tergite has the posterior end bifurcate (except for <i>A. formosana</i> Matsumura, 1927), similar to that of the <i>eronioides</i> and <i>livida</i> species-groups, while the posterior end of the 8th tergite is flat in the <i>geoffi</i> species-group. 4) In male genitalia the distal end of valva bears numerous small spines, while in the <i>livida</i> species-group the distal end of valva bears two dent-like processes, in the <i>eronioides</i> species-group the distal end of sacculus forms a horn-like process and in the <i>geoffi</i> species-group the distal end of sacculus varies from bearing a triangular process or lobate process with the outer margin covered by spinules. 5) Juxta lobes are simple and spiniform, similar to those of the <i>eronioides</i> and <i>livida</i> species-groups, while in the <i>geoffi</i> species-group the juxta lobes significantly expand distally and are covered by numerous piliform spinules.</p> <p> <b>Remarks.</b> Following the transfer of <i>Agalope glacialis</i> (Moore, 1872) to the genus <i>Paragalope</i> <b>gen. n.</b> in the present study, the name <i>Agalope glacialis</i> Butler, 1881 is no longer the junior secondary homonym of the name <i>A. glacialis</i> (Moore, 1872). According to the Article 59.4 of ICZN (1999) (“A species-group name rejected after 1960 on grounds of secondary homonymy is to be reinstated as valid by an author who considers that the two species-group taxa in question are not congeneric, unless it is invalid for some other reason.”), the name <i>A. glacialis</i> Butler, 1881 is reinstated as valid here and the replacement name of the former, <i>A. butleri</i> Owada & Horie, 2000 <b>syn. n.</b> is unnecessary and regarded as a junior objective synonym of <i>A. glacialis</i>. This species was recently discovered in Jilong County, Xizang Autonomous Region at the border of China and Nepal, the first record from China. <i>Agalope glacialis</i> (Figs 3–6, 66, 67) is closely related to <i>A. hyalina</i> (Figs 1, 2, 51, 64, 65, 93, 108) and can be distinguished from it by the hindwing ground color white or greyish white instead of creamy white in <i>A. hyalina</i>. However, in the male genitalia of both species no substantial difference can be found thus the true relationship between these two species requires further investigation.</p> <p> <b>Species composition</b></p> <p> <i>A. formosana</i> Matsumura, 1927</p> <p> <i>A. hyalina</i> (Kollar, 1844)</p> <p> <i>A. glacialis</i> Butler, 1881</p> <p> <i>A. grandis</i> Mell, 1922</p> <p> <i>A. harutai</i> Horie, 2000 (in Owada & Horie, 2000)</p> <p> <i>A. jianqingi</i> S.-Y. Huang, 2022 (in Huang <i>et al</i>. 2022)</p> <p> <i>A. kishidaograndis</i> Owada & Horie, 2000</p> <p> <i>A. mineti</i> Owada, 2000 (in Owada & Horie, 2000)</p> <p> <i>A. primularis</i> Butler, 1875</p> <p> <i>A. suzukikojii</i> Horie, 2000 (in Owada & Horie, 2000)</p>Published as part of <i>Huang, Si-Yao, Horie, Kiyoshi, Fan, Xiao-Ling, Wang, Min & Espeland, Marianne, 2023, A review of the genus Agalope Walker (Lepidoptera, Zygaenidae, Chalcosiinae) with taxonomic notes and descriptions of three new genera and three new species, pp. 291-321 in Zootaxa 5284 (2)</i> on pages 294-295, DOI: 10.11646/zootaxa.5284.2.4, <a href="http://zenodo.org/record/7923410">http://zenodo.org/record/7923410</a>
Book Reviews : MIZUCHI Muneaki, YAMAGUCHI Yoshihisa, and HORIE Satoshi, eds., Introduction to the Study of Neoplatonism
No full textSeparation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography
No full textHayashida M., Suzuki R., Horie S., et al. Separation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography. Journal of Chromatography A 1744, 465731 (2025); https://doi.org/10.1016/j.chroma.2025.465731.With recent advancements concerning the optimization of the analytical conditions, it is feasible to analyze polar molecules using supercritical fluid chromatography (SFC). In this study, the applicability of SFC is evaluated for analyzing 5-, 10-, 15-, and 18-mer oligonucleotides, and SFC is then applied to analyze deaminated products, which are side products generated during oligonucleotide synthesis. These side products are difficult to separate from the target oligonucleotide, with the difficulty varying depending on the deamination position and sequences, even when using ion-pair reversed-phase liquid chromatography (IP-RPLC), a common method for oligonucleotide analysis. Our results demonstrate that SFC, with octylamine as a modifier additive, can achieve sharp chromatographic peaks for 5-, 10-, 15-, and 18-mer oligonucleotides modified with 2′-O-methoxyethyl RNA (2′-MOE), regardless of the presence of the hydrophobic 4,4′-dimethoxytrityl (DMTr) group on the sequence. After optimization of the column oven temperature, modifier additive, and stationary phase, SFC successfully separated oligonucleotides with various numbers and positions of deamination from the target oligonucleotide. SFC exhibited different selectivities for DMTr-on and DMTr-off oligonucleotides compared with those for IP-RPLC, which indicates that SFC can serve as a valuable alternative tool for the purification and analysis of oligonucleotides
キョウユウデンセイ テイブンシ ジョウチャク ハクマク ニ オケル ブンキョク ハッセイ カテイ ノ カイメイ ト シンキ デバイス オウヨウ
No full text京都大学0048新制・課程博士博士(工学)甲第13823号工博第2927号新制||工||1432(附属図書館)UT51-2008-C739京都大学大学院工学研究科電子工学専攻(主査)教授 松重 和美, 教授 木本 恒暢, 教授 木村 俊作学位規則第4条第1項該当Doctor of EngineeringKyoto UniversityDA
Hard Instance Generation for SAT
No full text. We consider the problem of generating hard instances for the Satisfying Assignment Search Problem (in short, SAT). It is not known whether SAT is difficult on average, while it has been believed that the Factorization Problem (in short, FACT) is hard on average. Thus, one can expect to generate hard-on-average instances by using a reduction from FACT to SAT. Although the asymptotically best reduction is obtained by using the Fast Fourier Transform [SS71] (in short, FFT), its constant factor is too big in practice. Here we propose to use the Chinese Remainder Theorem for constructing efficient yet simple reductions from FACT to SAT. First by using the Chinese Remainder Theorem recursively, we define a reduction that produces, from n bit FACT instances, SAT instances in the conjunctive normal form with O(n 1+ffl ) variables, where ffl ? 0 is any fixed constant. (Cf. The reduction using FFT yields instances with O(n log n log log n) variables.) Next we demonstrate the efficiency of o..
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