1,720,971 research outputs found
Expression of p53 protein and index of cell proliferation (Ki-67) in squamous cell carcinoma of the mouth in patients with multiple tumors
No full textO avanco tecnico-cientifico da oncologia nas ultimas decadas possibilitou o aumento da sobrevida dos pacientes portadores de cancer, resultando na necessidade de reducao das sequelas e na possibilidade de prevencao do aparecimento de outras neoplasias ou segundo tumor primario. A ocorrencia deste, piora o prognostico para o paciente. Alem disso, alguns individuos com cancer de cabeca e pescoco podem sobreviver ao primeiro tumor primario, mas sucumbir em consequencia do segundo. Disso resulta a importancia de estudos que possam avaliar os fatores que estao relacionados a ocorrencia do segundo tumor primario. Os recentes avancos no estudo da biologia molecular vem demonstrando, dia a dia, a importancia dos marcadores tumorais, dentre estes a Ki-67 e a p53, ao qual foi atribuido um papel bastante significativo na carcinogenese. Objetivos: Correlacionar a expressao imunohistoquimica do marcador de Proliferacao Ki-67 e de supressao tumoral p53, em carcinomas epidermodes de boca em dois grupos de pacientes: Grupo A - apresentaram somente o primeiro tumor primario de boca e Grupo B - apresentaram segundo tumor primario. Metodo: Todos os individuos, de ambos os grupos tiveram diagnostico histopatologico de carcinomas epidermoides de celulas escamosas, sendo que o grupo A foi composto por 35 pacientes e Grupo B por 20, todos atendidos no Servico de Cirurgia de Cabeca e Pescoco do Hospital Erasto Gaertner de Curitiba-Parana, Brasil, no periodo de 1990 a 2005. Os prontuarios e todas as pecas fixadas em parafinas de todos os individuos dos dois grupos foram revistas e os tumores subclassificados quanto a positividade para proliferacao celular e para o p53 atraves da analise imunoistoquimica. Os testes aplicados foram o Teste de Proporcoes (Qui-Quadrado = X2) e teste de Medias (Teste-t). Resultados: nao houve positividade no padrao imunohistoquimico para p53 nos dois grupos, o que resultou em diferenciacao estatisticamente nao significante (p = 0,8768), logo nao foram encontradas diferencas entre as respostas do p53 entre os grupos A e B; ja o indice de proliferacao celular Ki-67 resultou em p=0,0519 e resultou em tendencia estatisticamente significante, tendo, portanto, diferenca entre as respostas medias do Ki-67 quanto ao percentual de coloracao entre os Grupos A e B, sendo que o Grupo B apresentou maior coloracao dos nucleos. Conclusoes: 1) A presenca de segundo tumor primario foi mais frequente na boca 2) A positividade para p53 nao apresentou diferenca estatisticamente significativas em relacao aos dois grupos 3) Nas condicoes do presente estudo houve uma tendencia estatisticamente significante para positividade do Ki-67 entre os dois grupos, mostrando que a positividade estaria associada a um risco maior do paciente apresentar o segundo tumor primarioBV UNIFESP: Teses e dissertaçõe
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Malignant Transformation of Actinic Cheilitis : a decade-long retrospective study in southern Brazil
No full textActinic cheilitis (AC), an oral potentially malignant oral disorder (OPMD), predominantly affects fair-skinned individuals, particularly males, with a higher prevalence in their sixth and seventh decades. In the Southeast region of Brazil, oral cancer ra
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
