197,004 research outputs found
Plasma levels of total sAPP in control and autistic patients.
No full text<p>Plasma levels of total sAPP (α and β) were assayed by Western blot from control and autistic patients. Autistic patients were classified as mild-to-moderate or severe based on clinical CARS score. Total sAPP bands were analyzed by scanning the final blot followed by densitometry, ImageJ quantification, and normalization against β-actin bands. Statistical significance was assessed using ANOVA. No significant differences observed in mean total sAPP levels between control or autistic patients.</p
APP and sAPP in wild-type and Thr<sup>668</sup>Ala mutant mouse brain.
No full text<div><p>(Left) APP and sAPP in wild-type (W) and mutant (M) mouse brain. Homogenates of brains taken from 12-month-old mice were fractionated as described and analyzed by immunoblotting for sAPP and APP holoprotein (22C11), APP (APP/C), phosphorylated APP (pThr<sup>668</sup>APP), sAPPα, sAPPβ and MAP2B.</p>
<p>Protein bands observed in the insoluble fraction (ppt panel) of sAPPβ are non-specific.</p>
<p>(Right) sAPP and APP levels are displayed.</p>
<p>The densities of the bands from soluble APP (sAPP) were standardized to the densities of MAP2B, and those from APP were standardized to the densities of actin.</p>
<p>All were normalized to unity for wild-type mice (1.0). The bars indicate means±S.D. (N.S.; n = 4).</p></div
The Impact of Social Desirability on an Individual’s Scale of Accurate Personality Prediction (SAPP) Score
No full textThe Scale of Accurate Personality Prediction (SAPP), developed by Miller (2000), was derived from the 16PF and purports to measure an individual’s ability to accurately assess his or her own self-knowledge. The scores from the SAPP are derived from calculating the absolute value of the difference between the individuals predicted scores on the 16PF, and the individual’s actual scores on the 16PF. The present study aimed to determine if individuals with lower SAPP scores were influenced by social desirability, and if social desirability perception differs by gender. Archival data of 607 individuals was organized into 150 low scoring SAPP individuals and analyzed through a series of T-tests on each of the 16PF 21 factors. Analyses indicated that Warmth (A+), Emotional Stability (C+), Rule Consciousness (G+), Social Boldness (H+), Sensitivity (I+), Abstractness (M-), Apprehension (O-), Perfectionism (Q3+). Tough Mindedness (TM-), and Self Control (SC+) showed a significant difference between obtained and predicted scores. Male respondents did not show significant differences in Social Boldness, and males showed additional significant difference in Tension (Q4-). Implications, limitations, and suggestions for further research are discussed
Dataset from the water-power nexus modelling of the Southern African Power Pool (SAPP)
No full textInput datasets and simulation results of the Southern African Power Pool (SAPP) simulations conducted with Dispa-SET, The underlying assumptions and the model are described in this technical report.
Full citation of the technical report:
Busch, S., De Felice, M. and Hidalgo Gonzalez, I., Analysis of the water-power nexus in the Southern African Power Pool, EUR 30322 EN, Publications Office of the European Union, Luxembourg, 2020, ISBN 978-92-76-21015-3 (online), doi:10.2760/920794 (online), JRC121329
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Secreted Amyloid Precursor Protein Alpha (sAPPα) Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes
No full textSecreted amyloid precursor protein alpha (sAPPα), processed from a parent mammalian brain protein, amyloid precursor protein, can modulate learning and memory. Recently it has been shown to modulate the transcriptome and proteome of human neurons, including proteins with neurological functions. Here, we analysed whether the acute administration of sAPPα facilitated changes in the proteome and secretome of mouse primary astrocytes in culture. Astrocytes contribute to the neuronal processes of neurogenesis, synaptogenesis and synaptic plasticity. Cortical mouse astrocytes in culture were exposed to 1 nM sAPPα, and changes in both the whole-cell proteome (2 h) and the secretome (6 h) were identified with Sequential Window Acquisition of All Theoretical Fragment Ion Spectra–Mass Spectrometry (SWATH-MS). Differentially regulated proteins were identified in both the cellular proteome and secretome that are involved with neurologically related functions of the normal physiology of the brain and central nervous system. Groups of proteins have a relationship to APP and have roles in the modulation of cell morphology, vesicle dynamics and the myelin sheath. Some are related to pathways containing proteins whose genes have been previously implicated in Alzheimer’s disease (AD). The secretome is also enriched in proteins related to Insulin Growth Factor 2 (IGF2) signaling and the extracellular matrix (ECM). There is the promise that a more specific investigation of these proteins will help to understand the mechanisms of how sAPPα signaling affects memory formation
Substituted Polypyridine Complexes of Cobalt(II/III) as Efficient Electron-Transfer Mediators in Dye-Sensitized Solar Cells
No full textA number of cobalt complexes of substituted polypyridine ligands were synthesized and
investigated as possible alternatives to the volatile and corrosive iodide/triiodide redox couple commonly
used as an electron-transfer mediator in dye-sensitized solar cells (DSSCs). The extinction coefficients in
the visible spectrum are on the order of 102 M-1 cm-1 for the majority of these complexes, diminishing
competition with the light-harvesting dye. Cyclic voltammetric studies revealed a dramatic surface
dependence of the heterogeneous electron-transfer rate, which is surprisingly different for gold, carbon,
and platinum electrodes. DSSCs were assembled using a mediator that consisted of a mixture of Co(II)
and Co(III) complexes in a 10:1 ratio. DSSCs containing these mediators were used to characterize incident
photon-to-current conversion efficiency and photoelectrochemical responses. The best performing of these
mediators were identified and subjected to further study. As suggested by electrochemical results, gold
and carbon are superior cathode materials to platinum, and no evidence of corrosion on any cathode material
was observed. Addition of lithium salts to the mediator solution resulted in a dramatic improvement in cell
performance. The observed Li+ effect is explained in terms of the recombination of injected electrons in
the photoanode with the oxidized mediator. The best mediator, based on tris(4,4¢-di-tert-butyl-2,2¢-dipyridyl)-
cobalt(II/III) perchlorate, resulted in DSSCs exhibiting efficiencies within 80% of that of a comparable iodide/
triiodide-mediated DSSC. Due to the commercial availability of the ligand and the simplicity with which the
complex can be made, this new mediator represents a nonvolatile, noncorrosive, and practical alternative
as an efficient electron-transfer mediator in DSSCs
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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