130,792 research outputs found
Memo from Tim Fanning to M.E. Kramer, D. Santillo
No full textFanning to E. Veasy, M.E. Kramer, D. Santillo re: Hobart 2nd floor. Memo is dated 1/10, but no year is give
Stochastic joint replenishment problem under a fill rate constraint with controllable lead times and shared cost allocation
No full textIn a family of items under coordinated inventory replenishments, some products may be replenished at the same time, which in turn implies that some lead time components and costs may be shared among them. This paper investigates this aspect in the context of the joint replenishment problem under the class of cyclic policies, assuming random demands and controllable lead times, and imposing a fill rate constraint for each item.& COPY; 2023 Elsevier B.V. All rights reserved
Controlling lead times and minor ordering costs in the joint replenishment problem with stochastic demands under the class of cyclic policies
No full textIn this paper, we consider the periodic review joint replenishment problem under the class of cyclic policies. For each item, the demand in the protection interval is assumed stochastic. Moreover, a fraction of shortage is lost, while the other quota is backordered. We suppose that lead times and minor ordering costs are controllable. The problem concerns determining the cyclic replenishment policy, the lead times, and the minor ordering costs in order to minimize the long‐run expected total cost per time unit. We established several properties of the cost function, which permit us to derive a heuristic algorithm. A lower bound on the minimum cost is obtained, which helps us to evaluate the effectiveness of the proposed heuristic. The heuristic is also compared with a hybrid genetic algorithm that is specifically developed for benchmarking purposes. Numerical experiments have been carried out to investigate the performance of the heuristic
Current knowledge of D-aspartate in glandular tissues
No full textFree D-aspartate (D-Asp) occurs in substantial amounts in glandular tissues. This paper reviews the existing work on D-Asp in vertebrate exocrine and endocrine glands, with emphasis on functional roles. Endogenous D-Asp was detected in salivary glands. High D-Asp levels in the parotid gland during development suggest an involvement of the amino acid in the regulation of early developmental phases and/or differentiation processes. D-Asp has a prominent role in the Harderian gland, where it elicits exocrine secretion through activation of the ERK1/2 pathway. Interestingly, the increase in NOS activity associated with D-Asp administration in the Harderian gland suggests a potential capability of D-Asp to induce vasodilatation. In mammals, an increase in local concentrations of D-Asp facilitates the secretion of anterior pituitary hormones, i.e., PRL, LH and GH, whereas it inhibits the secretion of POMC/α-MSH from the intermediate pituitary and of oxytocin from the posterior pituitary. D-Asp also acts as a negative regulator for melatonin synthesis in the pineal gland. Further, D-Asp can stereo-specifically modulate the production of sex steroids, thus taking part in the endocrine control of reproductive activity. Although D-Asp receptors remain to be characterized, gene expression of NR1 and NR2 subunits of NMDAr responds to D-Asp in the testis. © 2014 Springer-Verlag
D. Ivone, La politica monetaria a Napoli nel Settecento borbonico. La disputa dottrinaria tra Trojano Spinelli e Carlo Antonio Broggia in un documento “americano”.
No full textInfluence of lamb rennet paste containing probiotic on proteolysis and rheological properties of pecorino cheese.
No full textPecorino cheeses made from heat-treated ewes’ milk
using traditional lamb rennet paste (RP), lamb rennet
paste containing Lactobacillus acidophilus (LA-5;
RPL), and lamb rennet paste containing a mix of Bifidobacterium
lactis (BB-12) and Bifidobacterium longum
(BB-46; RPB) were characterized for proteolytic
and rheological features during ripening. Consumer acceptance
of cheeses at 60 d of ripening was evaluated.
Lactobacillus acidophilus and Bifidobacterium mix displayed
counts of 8 log10 cfu/g and 9 log10 cfu/g, respectively,
in cheese during ripening. The RPB cheese displayed
a greater degradation of casein (CN) matrix
carried out by the enzymes associated to both Bifidobacterium
mix and endogenous lactic acid microflora,
resulting in the highest values of non-CN N and watersoluble
N and the highest amount of αs-CN degradation
products in cheese at 60 d of ripening. The RPL cheese
displayed intermediate levels of lactic acid bacteria and
of N fractions. The percentage of γ-CN in RP and RPL
cheeses at 60 d was 2-fold higher than in the cheese
curd of the same groups, whereas the mentioned parameter
was 3-fold higher in RPB cheese than in the corresponding
fresh curd according to its highest plasmin
content. The lower hardness in RPB at the end of ripening
could be ascribed to the greater proteolysis observed
in cheese harboring the Bifidobacterium mix. Although
differences in proteolytic patterns were found among
treatments, there were no differences in smell and
taste scores
New insights into D-aspartate signaling in testicular activity.
No full textD-aspartate (D-Asp) is an amino acid found in high concentrations in the testis and pituitary gland. Increasing evidence suggests that D-Asp promotes spermatogenesis by activating testosterone production in the Leydig cells via LH release from the pituitary gland. In vitro studies indicate that D-Asp may also influence steroidogenesis and spermatogenesis through autocrine and paracrine signals. D-Asp enhances StAR and steroidogenic enzyme expressions, facilitating testicular cell proliferation via the GluR/ERK1/2 pathway. Moreover, it supports spermatogenesis by enhancing the mitochondrial function in spermatocytes, aiding in the metabolic shift during meiosis. Enhanced mitochondrial function, along with improved MAM stability and reduced ER stress, has been observed in Leydig and Sertoli cells treated with D-Asp, indicating potential benefits in steroidogenesis and spermatogenesis efficiency. Conversely, D-Asp exerts a notable anti-apoptotic effect in the testis via the AMPAR/AKT pathway, potentially mediated by antioxidant enzyme modulation to mitigate testicular oxidative stress. This review lays the groundwork for future investigations into the molecules promoting spermatogenesis by stimulating endogenous testosterone biosynthesis, with D-amino acids emerging as promising candidates
Considering greenhouse gas emissions in a single vendormultiple buyer coordinated supply chain
No full textA periodic review policy for a coordinated single vendor-multiple buyers supply chain with controllable lead time and distribution-free approach
No full textIn this paper, we study a single vendor-multiple buyer integrated inventory model with controllable lead time and backorders-lost sales mixture. Each buyer adopts a periodic review policy in which the review period is an integer fraction of the production cycle time of the vendor. To reflect the practical circumstance characterized by the lack of complete information about the demand distribution, we assume that only the first two moments of the demand during the protection interval are known. The long-run expected total cost per time unit is derived, which includes stockout costs. The problem is to determine the length of the inventory cycle of the vendor, the produce-up-to level for the vendor, the replenishment policy of each buyer, and the length of lead times that minimize the cost function under the minimax distribution-free approach. Two alternative heuristics are proposed. Numerical experiments have been carried out to investigate the performance of the heuristics and to study the sensitivity of the model
- …
