17 research outputs found
A study of metaheuristic algorithms for high dimensional feature selection on microarray data
No full textStructure and conduct of risk returns-characteristics of residential property investment in Kaduna metropolis, Nigeria
No full textResidential property investment is one of the most subscribed investments in the world. However, its risk-return characteristics is least understood especially in the Nigeria context. Though past studies have critically established the performance of mostly isolated residential and commercial properties in southern regions of Nigeria. Disentangling and identifying empirically risk-return characteristic of residential property in Kaduna metropolis Northwest Nigeria is an unresolved challenge. This paper presents an empirical analysis of the performance of residential properties to gain a better understanding of the property market dynamics in Nigeria, survey research approach was employed to collect quantitative data required for the study. To determine residential property returns and asset risk, descriptive (weighted means, standard deviation and percentages) and inferential statistics were utilised. The outcome demonstrated that residential properties have diverse total returns and riskreturn characteristic. Furthermore, this study established that total returns from residential properties ranged between 7.93% to 12.68 % and the risk features ranged from 2.37% to6.81% among the classes of properties. The result demonstrates a direct positive relationship between total returns and risk profile. Hence, recommends that Malali market is the most desirable location for risk-averse investors.
Keywords: Risk- return analysis, residential investment, total return, portfolio, propert
POLIGAMI DAN PELAKOR, REFLEKSI DALAM FILM DAN REALITAS MASYARAKAT GORONTALO: SEBUAH STUDI PERBANDINGAN
No full textNowadays, the issue of polygamy and homewrecker was an idea. It was found in two platforms such as the soap operas Suara Hati Istri and social reality in real life. Communal Gorontalo was the best prototype regarding these two issues. The motives, either polygamy or homewrecker in operas and in reality, were different. Soap operas put forward the basic trend and modernism as the basis, while the real life of the Gorontalo community proposed religion and legal awareness in its dynamics. Looking for the most fundamental thing connecting the two areas, the author used feminism theory as a comparative study. This study asked three questions such as (1) how was the reflection of polygamy and homewrecker in the Suara Hati Istri serial?; (2) what was the reflection of polygamy and homewrecker in the reality of Gorontalo society?; (3) what were the ideological concepts of polygamy and homewrecker in the series of Suara Hati Istri and in the reality of the Gorontalo community? Feminism succeeded found the fundamental reason for the similarities in the plurality of motives between soap operas and reality. It was toxic masculinity and misogynist
REDEFINISI PEREMPUAN CANTIK DALAM CERPEN RATIH KUMALA DAN AGUS NOOR
No full textThis research was started from the problem of two female characters of TPI
and KYJ that are intimidated by the ideal beauty creation from outside themselves.
The female characters were analyzed being person who cannot choose the way how
to express who they truly are, because many authors have set a beautiful construction
over their bodies. It is similar to what has been done by the beauty myth against
women in real life. This principle was applied by the authors to their characters. Thus,
this research attempts to examine how the beauty myth oppresses women in real life,
and how the authors redefined the beauty myth to eventually oppress the characters in
the short story.
This research used theory of the myth of beauty which developed by Naomi
Wolf. This theory was needed to help the researcher in seeing the problems of beauty
which developed in short story by Kumala and Noor. The myth of beauty can be a
magnifier in order to analyze the extent of this theory in oppressing women and how
the author subdued and eventually followed to set the standards of the ideal beauty.
In this research, it was found that through TPI and KYJ, both authors
attempted to break away from the restraints of the beauty myth. However, they even
unconsciously eternalize it through the establishment concept of ideal to the
characters. Contestation occurred between the authors� desire to get out of the beauty
myth and the fact that they are still locked in handfuls of the beauty myth itself. Ideas
collisions occur not only between the authors and the beauty myth, but also between
the characters and the authors. In order to face the reality that binds and oppress their
bodies, the characters tried to break the ideal concept that has been redefined by the
authors. The final result is the contestation and collisions further strengthen the fact
that the concept of ideal beauty is merely relative
Cardiovascular Health and Risk Factors Among Adult Study Participants: Insights from Sociodemographic Characteristics and Health Behaviors
No full textBackground: Cardiovascular diseasesconstitute a significant global health challenge, necessitating a comprehensive understanding of their risk factors. This study explores the interplay between sociodemographic characteristics, health behaviors, and cardiovascular health among adult participants.
Aim: The study aims to assess the cardiovascular health status and risk factors in adults, considering sociodemographic characteristics and health behaviors.
Methods: In the Inter-University Consortium for Political and Social Research Study (ICPSR146521), data that had been gathered prospectively were used to assess the prevalence of metabolic syndrome, its risk factors, and the linked lifestyle in adult Myanmar inhabitants.
Results: The study found that age was significantly associated with cardiovascular health, with an increase in age correlating with elevated risk. While gender was not a significant predictor, marital status and occupation played roles in shaping cardiovascular health outcomes. Smoking and sedentary lifestyles were identified as substantial risk factors, while physical exercise and healthier dietary habits demonstrated protective effects. Regression analysis further underscored the influence of BMI, age, and total cholesterol on cardiovascular health.
Conclusion: This study provides critical insights into the complex interplay between sociodemographic characteristics, health behaviors, and cardiovascular health among adults. The findings emphasize the significance of age, smoking, physical activity, and dietary choices in shaping cardiovascular risk. Tailored interventions and public health strategies that consider these factors can enhance cardiovascular diseases prevention and management efforts, ultimately contributing to a reduction in the global burden of cardiovascular diseases
Exploring the Relationship between PheSA Scores and Ligand Efficiency in the Discovery of Potent Antimalarials: A Computational Perspective
No full textPharmacophore Enhanced Shape Alignment (PheSA) compares the similarities of compounds based on their pharmacophoric and geometrical characteristics. Ligand efficiency is a notion used to maximize the potency and effectiveness of medication candidates by taking into account their molecular weight and binding affinity. This study mainly focused on Cycloguanil analogues to evaluate the association between PheSA scores and ligand efficiency in the identification of effective antimalarials. Information on 36 PfDHFR inhibitors, their structures and biological activity was retrieved from the ChEMBL database. Based on shape and pharmacophore similarity, the PheSA algorithm was used to compare the 3D structures of the inhibitors. Based on a de novo synthesis method, 257 new compounds with greater PheSA similarity scores that have a striking resemblance to cycloguanil were created. The PheSA score and ligand efficiency have a moderately positive link (correlation coefficient of 0.675) according to the analysis. However, the virtual screening of cycloguanil analogues based on PheSA similarity scores offers a useful initial evaluation of structural similarity, directing further experimental studies to find interesting substances for the creation of effective antimalarial drug
Gas flaring effects and revenue made from crude oil in Nigeria
No full textThe study examines gas flaring and crude oil revenue in Nigeria.The study used secondary data for 14 years from 2000 to 2014 inclusive to analyze the issue using multiple regression analysis. The study employed time series data hence, a unit root test is conducted and found that they are stationary at level.Using three variables, gas flaring as the aggregate amount of gas flared by oil producing companies in Nigeria as an independent variable and crude oil revenue as an aggregate of revenue generated from all oil companies crude oil as dependent variable and tax as penalty on flaring is used as a control variable, the findings of the study show that gas flaring has a negative impact on Nigerian crude oil revenue and is statistically significant.From the research there are strong indications that the implementation of regulations and incentives to abate gas glaring in Nigeria has to be improving
in other to increase revenue generated from crude oil. The author suggests that government should embark seriously on gas utilization policy and
increase the penalty for companies who still engage in gas flaring. In addition, the government should utilize the gas flaring for electricity generation or implore another means of either utilizing it or curtail it
Hormone Receptors and Her-2/neu Overexpression in Breast Carcinomas in Patients of West African Origin Seen at Lagos State University Teaching Hospital, Nigeria
No full textGermline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and Nigeria
No full textSomatic mutation signatures may represent footprints of genetic and environmental exposures that cause different cancer. Few studies have comprehensively examined their association with germline variants, and none in an indigenous African population. SomaticSignatures was employed to extract mutation signatures based on whole‐genome or whole‐exome sequencing data from female patients with breast cancer (TCGA, training set, n = 1,011; Nigerian samples, validation set, n = 170), and to estimate contributions of signatures in each sample. Association between somatic signatures and common single nucleotide polymorphisms (SNPs) or rare deleterious variants were examined using linear regression. Nine stable signatures were inferred, and four signatures (APOBEC C>T, APOBEC C>G, aging and homologous recombination deficiency) were highly similar to known COSMIC signatures and explained the majority (60–85%) of signature contributions. There were significant heritable components associated with APOBEC C>T signature (h 2 = 0.575, p = 0.010) and the combined APOBEC signatures (h 2 = 0.432, p = 0.042). In TCGA dataset, seven common SNPs within or near GNB5 were significantly associated with an increased proportion (beta = 0.33, 95% CI = 0.21–0.45) of APOBEC signature contribution at genome‐wide significance, while rare germline mutations in MTCL1 was also significantly associated with a higher contribution of this signature (p = 6.1 × 10−6). This is the first study to identify associations between germline variants and mutational patterns in breast cancer across diverse populations and geography. The findings provide evidence to substantiate causal links between germline genetic risk variants and carcinogenesi
Abstract LB-300: The life history of breast cancer in Nigerian women: Evidence for ethnic differences in tumor evolution based on whole-genome sequencing
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