107 research outputs found
Mechanismen und Nutzen der Prädiabetes-Remission durch Lebensstilintervention
No full textEine Lebensstilintervention bei Menschen mit Prädiabetes kann das Risiko einer Progression zum Diabetes mellitus Typ 2 verringern, was am effektivsten durch eine Rückkehr zu normaler Glukoseregulation erreicht wird. Die Effekte der Lebensstilintervention sind im Kontext eines Gewichtsverlusts hauptsächlich durch eine Verbesserung der Insulinsensitivität vermittelt. Innerhalb der heterogenen Subcluster des Prädiabetes gibt es jedoch einen Anteil an Patienten mit besonders hohem metabolischem Risiko, die im Rahmen ihrer umfassenden Reduktion des Leberfettanteils auch ihre Insulinsekretion verbessern können. Diese Erkenntnis ist ein wichtiger Schritt in Richtung Präzisionsdiabetologie, mit deren Hilfe in Zukunft maßgeschneiderte Therapien und Interventionen im Kontrast zum jetzigen one size fits all-Ansatz dabei helfen wird, die Last durch Diabetes mellitus Typ 2 und assoziierte Folgeerkrankungen zu reduzieren.
Die besondere Bedeutung des ektopen Fettgewebes in der Pathogenese des Diabetes mellitus Typ 2 im Stadium des Prädiabetes verdeutlicht, dass eine präferentielle Reduktion des viszeralen Fettgewebes im Rahmen eines Körpergewichtsverlustes Vorteile bietet, was durch konkrete Zielwerte monitoriert werden kann.
Interessanterweise unterscheidet sich der Mechanismus der Remission des Prädiabetes deutlich von der Remission des Diabetes mellitus Typ 2, insbesondere hinsichtlich der Rolle der Insulinsekretion. Auch hier öffnet sich ein Fenster für maßgeschneiderte präventive Interventionen.
Wir definieren in der vorliegenden Arbeit das Konzept der Prädiabetes-Remission und zeigen deren präventives Potential hinsichtlich der Reduktion des Risikos, einen Diabetes mellitus Typ 2 zu entwickeln und potenziellen Vermeidung von Typ 2 Diabetes assoziierten Komplikationen. Unsere Ergebnisse sowohl hinsichtlich der Mechanismen der Prädiabetes-Remission als auch seine protektiven Effekte konnten wir in der bislang größten Diabetes-Präventionsstudie in der westlichen Welt (DPP) reproduzieren. Wir schlagen daher vor, das glykämische Ziel einer Normalisierung des Glukosestoffwechsels neben der bereits empfohlenen Reduktion des Körpergewichts als Primärziel für das Management von Patienten mit Prädiabetes in aktuelle Leitlinien aufzunehmen
Kenelle maa kuuluu? Kansakuva Arvid Järnefeltin pamfletissa Maa kuuluu kaikille!
No full textTo whom the land belongs? The concept of people in Arvid Järnefelt’s pamphlet Maa kuuluu kaikille!
In his pamphlet Maa kuuluu kaikille! [The land belongs to everybody], published in 1907, the Finnish author Arvid Järnefelt stresses the ‘human rights’ of workers to utilize land. Published after a crofters’ strike and the large-scale eviction followed by it, the book took part in the debate on the societal power relations. Following the teachings of Leo Tolstoy, Järnefelt believed in the equality for all, regardless of wealth, education or class. In this article, Järnefelt’s pamphlet is analyzed as a variation of the early 20th century discussion on nation and people in Finland. The significance of the concept of ‘people’ was not fixed but under ongoing construction.
The article shows the ambivalent position of Järnefelt as the spokesman of the people. Järnefelt’s pamphlet is directed to the intelligentsia living in cities rather than the workers of the countryside. Järnefelt himself was a certain kind of hybrid, a member of the upper class ‘mimicking’ the workers. The power relations that Järnefelt sketches in his book resemble the hierarchy of centre and periphery as theorized in postcolonial criticism. When compared to previous discourses, the ideal yeoman that Järnefelt portrays in his pamphlet represents quite clearly a new kind of subject, who will refuse to work if his demands for justice are not dealt with. Although Järnefelt had an outsider’s view to the harsh reality of the farm workers, but his Tolstoyan message was definitely empowering
I Remember column in which author Wendy Anderson describes a Christmas Eve in
No full textI Remember column in which author Wendy Anderson describes a Christmas Eve in the 1960s when her family waited anxiously for her father, Arvid, to return home to Monson during a snowstorm. Her father arrived safely on Christmas afternoon, after digging his car out from nearly three feet of snow
An advanced LED-based setup enabling characterization of full-size modules at different temperatures and spectra
No full textStandard IV characterization of solar cells and modules is typically performed with Xe-, W- and/or metalhalide-based systems. These are either built around a flash or a steady-state illumination. However, there is a growing trend towards LED-based systems, which allows both flash and steady-state white-light illumination, as well as spectrally-tuned irradiance, broadening the scope of measurements from IV to also include spectral dependencies [1]. In this paper we introduce an advanced LED-based setup for modules and investigate its potential for spectrally-tuned measurements as a function of temperature. While the impact of temperature in measured currents and resulting extraction of accurate EQE requires further fine-tuning of the equipment, some applications with comparative measurements are elaborated to demonstrate the approach and capabilities at its current stage.The work in this paper was partially funded by the Kuwait Foundation for the Advancement of Sciences under project number P115-15EE-01, by the Flemish government within the projects SolsThore, LenoPV and ICONTWILL-BIPV, and by the partners in the imec SiPV industrial affiliation programme. Additionally, we also want to acknowledge Geert, Luc and Reinoud from our technical team for their support in the installation, maintenance and improvement of the new facilities and equipment with all its challenges, that is instrumental for obtaining these results and further progress in our research. Finally, we also want to acknowledge Soltech for the supply of printed glass.Govaerts, J (corresponding author), IMEC, EnergyVille, Thorpk 8320, B-3600 Genk, Belgium.
[email protected]
Wind-tunnel study of the East Huntington Bridge (concrete cable-stayed alternate)
No full textFor Arvid Grant and Associates, Inc.August 1980.CER80-81JEC-BB-JAP5
Survey on open peer review: Attitudes and experience amongst editors, authors and reviewers
No full textOpen peer review (OPR) is a cornerstone of the emergent Open Science agenda. Yet to date no large-scale survey of attitudes towards OPR amongst academic editors, authors, reviewers and publishers has been undertaken. This paper presents the findings of an online survey, conducted for the OpenAIRE2020 project during September and October 2016, that sought to bridge this information gap in order to aid the development of appropriate OPR approaches by providing evidence about attitudes towards and levels of experience with OPR. The results of this cross-disciplinary survey, which received 3,062 full responses, show the majority (60.3%) of respondents to be believe that OPR as a general concept should be mainstream scholarly practice (although attitudes to individual traits varied, and open identities peer review was not generally favoured). Respondents were also in favour of other areas of Open Science, like Open Access (88.2%) and Open Data (80.3%). Among respondents we observed high levels of experience with OPR, with three out of four (76.2%) reporting having taken part in an OPR process as author, reviewer or editor. There were also high levels of support for most of the traits of OPR, particularly open interaction, open reports and final-version commenting. Respondents were against opening reviewer identities to authors, however, with more than half believing it would make peer review worse. Overall satisfaction with the peer review system used by scholarly journals seems to strongly vary across disciplines. Taken together, these findings are very encouraging for OPR's prospects for moving mainstream but indicate that due care must be taken to avoid a "one-size fits all" solution and to tailor such systems to differing (especially disciplinary) contexts. OPR is an evolving phenomenon and hence future studies are to be encouraged, especially to further explore differences between disciplines and monitor the evolution of attitudes
Experimental investigations of welding induced temperature gradients and distortions in a segment of an OSD
No full textOrthotropic bridge decks are susceptible to fatigue cracks which are influenced by the thickness of their components, welding procedure, type of the weld, the position of the considered detail in relation to the local loading condition and by residual stresses due to welding. The above-mentioned parameters determine the detail category for fatigue resistance. This research focuses on an experimental investigation of the temperature distribution and distortions due to the welding of a connection between the deck plate, longitudinal stiffener and crossbeam. Three specimens were welded with dimensions of: 900x400 mm deck plate, 350mm deep trapezoidal longitudinal stiffener and 600mm long crossbeam in a workshop of a bridge fabricator. The crossbeams were manufactured with Haibach cope holes. The thickness of the deck plate and crossbeam was 15 mm, and the thickness of the longitudinal stiffener was 8mm. During the welding, the temperature was measured using a FLIRGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Steel & Composite Structure
[Oeconomica Scaniae]
No full textAnswers to questions about rural economy and other matters in Skåne.
At the end, Linnaeus has noted 'Camerer Grist', probably the author of the answers.
Not in Linnaeus's hand.
The title 'Oeconomica Scaniae' was given by Arvid H. Uggla
Role of weight loss-induced prediabetes remission in the prevention of type 2 diabetes: time to improve diabetes prevention
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