5,404 research outputs found
Introduction: Darwin-inspired learning
No full textThis book is both a celebration and a clarion call. It is a celebration of all that has been done by the Charles Darwin Trust and others to enhance education by drawing on Darwin’s life and ways of working. It is a clarion call because of the editors’ and authors’ beliefs that there is still much to be done
Simple rules to modify pre-planned paths and improve gross robot motions associated with pick & place assembly tasks
No full textPurposeThis paper aims to describe real time improvements to the performance and trajectories of robots for which paths had already been planned by some means, automatic or otherwise. The techniques are applied to industrial robots during the gross motions associated with pick and place tasks. Simple rules for path improvement are described.Design/methodology/approachThe dynamics of the manipulator in closed form Lagrange equations are used to represent the dynamics by a set of second‐order coupled non‐linear differential equations. The form of these equations is exploited in an attempt to establish some simple rules. Sub‐optimal paths are improved by considering simple rules developed from the model of the machinery dynamics. By considering the physical limitations of the manipulator, performance was improved by refining pre‐calculated paths. Experiments were performed with a prototype robot and an old Puma 560 robot in a laboratory environment. Once the method had been tested successfully then experiments were conducted with a Kuka KR125 Robot at Ford Motor Company. The measured quantities for all the robots were drive currents to the motors (which represented the torques) and the joint angular positions.FindingsThe method of path refinement presented in this paper uses a simplified model of the robot dynamics to successfully improve the gross motions associated with a pick and place task. The advantage of using the input‐output form described was that intermediate non‐linearities (such as gear friction) and the motor characteristics were directly incorporated into the model.Research limitations/implicationsEven though many of the theoretical problems in manipulator dynamics have been solved, the question of how to best apply the theories to industrial manipulators is still being debated. In the work presented in this paper, information on system dynamics is used to produce simple rules for “path improvement”.Practical implicationsMost fast algorithms are for mobile robots and algorithms are scarcer for manipulators with revolute joints (the most popular type of industrial robot). This work presents real time methods that allow the robot to continue working while new global paths are automatically planned and improved as necessary.Originality/valueMotion planning for manipulators with many degrees of freedom is a complex task and research in this area has been mostly restricted to static environments, offline simulation or virtual environments. This research is applied in real time to industrial robots with revolute joints.</jats:sec
Introducing AI into MEMS can lead us to brain-computer interfaces and super-human intelligence
No full text'De dokter vertelt mij wel wat er loos is': Een kwalitatief onderzoek naar patronen in het informatiegedrag van zorggebruikers
No full textItem does not contain fulltextVU University Amsterdam, 20 december 2016Promotor : Spooren, W.P.M.S. Co-promotores : Sanders, J.M., Haak, M.J. van den, Meijman, F.J.389 p
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
No full textSelf-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Condoms are more effective when applied by males: a study of young black males in the United States
No full textPurposeTo determine, among a sample of young black male (YBM), whether female application of male condoms for penile–vaginal intercourse would be associated with higher or lower rates of breakage or slippage. A secondary aim was to investigate if higher rates of breakage or slippage were associated with increased odds of acquiring chlamydia and/or gonorrhea.MethodsA cross-sectional study of 412 YBM, aged 15 to 23 years, was conducted in three US cities located in the Southern United States.ResultsAmong YBM reporting frequent female application of condoms, 43.5% reported one or more instance of breakage or slippage, compared with those reporting less frequent female application (27.2%, P = .003). Among YBM reporting one or more event of breakage or slippage, 25.4% tested positive for chlamydia and/or gonorrhea. In contrast, among those not reporting breakage or slippage, 17.2% tested positive (P = .047).ConclusionsFindings suggest that educational and behavioral interventions should seek to improve young women's skills relative to condom application and use. Further studies could also investigate whether intervention efforts should encourage some YBM to be responsible for their own condom application
Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset
No full textAcute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function. Intervening prior to the onset of a substantially increased inflammatory response may limit the associated damage to the airways. While a number of biomarker assays based on inflammatory markers have been developed, providing useful and important measures of disease during these periods, such factors are typically only elevated once the process of exacerbation has been initiated. Identifying biomarkers that can predict the onset of pulmonary exacerbation at an early stage would provide an opportunity to intervene before the establishment of a substantial immune response, with major implications for the advancement of cystic fibrosis care. The precise triggers of pulmonary exacerbation remain to be determined; however, the majority of models relate to the activity of microbes present in the patient's lower airways of cystic fibrosis. Advances in diagnostic microbiology now allow for the examination of these complex systems at a level likely to identify factors on which biomarker assays can be based. In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
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