4,342 research outputs found
Alvaro Sanchez
No full textPoster that encourages the Mexican people to vote for political candidate for Congress Alvaro Sanchez
Fracking : luchas sociales en tiempos de comunicación digital
Get PDFFil: Vargas Ferro, Alvaro Andrés. Universidad de San Andrés. Departamento de Ciencias Sociales; Argentina
Eficacia de la neuromodulación como herramienta para el tratamiento de lesiones deportivas. Revisión bibliográfica
No full textBarrio Sanchez, Alvaro; director de proyecto: González Pérez, Israel2023-2024Máster Universitario en Fisioterapia DeportivaFacultad de Ciencias de la Salu
Data for 'Effects of laser shock peening on mechanisms of short crack initiation and propagation'
No full textData supporting the paper Sanchez AG, You C, Leering M, Glaser D, Furfari D, Fitzpatrick ME, Wharton J, Reed PAS. "Effects of laser shock peening on mechanisms of short crack initiation and propagation" International Journal of Fatigue. Contains all data</span
Psychomotor Impairment Detection via Finger Interactions with a Computer Keyboard During Natural Typing
Get PDFModern digital devices and appliances are capable of monitoring the timing of button presses, or finger interactions in general, with a sub-millisecond accuracy. However, the massive amount of high resolution temporal information that these devices could collect is currently being discarded. Multiple studies have shown that the act of pressing a button triggers well defined brain areas which are known to be affected by motor-compromised conditions. In this study, we demonstrate that the daily interaction with a computer keyboard can be employed as means to observe and potentially quantify psychomotor impairment. We induced a psychomotor impairment via a sleep inertia paradigm in 14 healthy subjects, which is detected by our classifier with an Area Under the ROC Curve (AUC) of 0.93/0.91. The detection relies on novel features derived from key-hold times acquired on standard computer keyboards during an uncontrolled typing task. These features correlate with the progression to psychomotor impairment (p < 0.001) regardless of the content and language of the text typed, and perform consistently with different keyboards. The ability to acquire longitudinal measurements of subtle motor changes from a digital device without altering its functionality may allow for early screening and follow-up of motor-compromised neurodegenerative conditions, psychological disorders or intoxication at a negligible cost in the general population.Comunidad de Madri
Micro-mechanisms of fatigue and corrosion in a laser shock peened aerospace aluminium alloy.
No full textA laser shock peening treatment with ablative layer (LSP), and one without an ablative layer (LSPwC) were performed on AA7075-T651 (UNS A97075) to investigate their effects on the micro-mechanisms of fatigue, corrosion and fatigue of pre-corroded pits. Surface and microstructural characterisation techniques (micro-hardness, SEM-EBSD, contactprofilometry, incremental hole drilling, X-ray diffraction) showed the laser shock peening treatments generated high residual stress fields of up to –400 MPa, with LSPwC having 14% higher subsurface compressive residual stresses than LSP. Both showed limited hardness increase, with a limited surface roughness increase for LSP, and moderate for LSPwC. Fatigue testing showed a two-order magnitude increase in LSP AA7075 T651 overall life, due to the mechanism of crack initiation changing from surface second-phase particles to subsurface crack initiation dependent on the local stress field. Laser peening-induced defects in LSP (in some cases), and the surface roughness in LSPwC, were able to prevent AA7075- T651 from achieving maximum fatigue performance enhancement. This highlighted the importance of the interplay between surface features and residual stress on the micromechanism of crack initiation, and provided new insights into using this knowledge to maximise fatigue life extension. Modelling work by collaborators has used this experimental data to quantitatively evaluate the proposed mechanisms and is briefly reported in the discussion of the PhD results. LSP and LSPwC AA7075-T651 were also exposed to 3.5 wt.% sodium chloride solution under several electrochemical protocols (open-circuit potential, potentiodynamic sweep, galvanostatic control). The compressive residual stresses did not significantly affect the corrosion behaviour, corrosion pit morphology or pit depth. Additionally, laser shock peening-induced surface roughness was shown to have the most detrimental impact on corrosion performance. However, there was no clear indication of long-term changes in corrosion performance. The fatigue performance from pre-corroded pits in peened AA7075-T651 was also studied. It showed pits act as stress concentrations, causing cracks to initiate shortly after dynamic loading, reducing fatigue life by 50%. The laser shock peening treatments markedly increased fatigue life, by up to 400% compared to corroded untreated AA7075-T651, due to the residual stresses effectively counteracting the stress concentrations of the pits. Laser shock peened AA7075-T651, even after suffering subsequent pitting corrosion, can be expected to have fatigue performance as good as, or better than, standard untreated AA7075-T651
Trinidad Sanchez-Pacheco, Maria Dolors Giral, Juan Zozaya, Natacha Sesena, Isabel Alvaro Zamora, Joan Ainaud de Lasarte, Maria Antonia Casano-vas, Balbina Martinez Caviro, Ceramica esmalta espanola, 1981
No full textDémians d'Archimbaud Gabrielle. Trinidad Sanchez-Pacheco, Maria Dolors Giral, Juan Zozaya, Natacha Sesena, Isabel Alvaro Zamora, Joan Ainaud de Lasarte, Maria Antonia Casano-vas, Balbina Martinez Caviro, Ceramica esmalta espanola, 1981. In: Archéologie médiévale, tome 13, 1983. pp. 367-368
Operator Sequence Alters Gene Expression Independently of Transcription Factor Occupancy in Bacteria
Get PDFA canonical quantitative view of transcriptional regulation holds that the only role of operator sequence is to set the probability of transcription factor binding, with operator occupancy determining the level of gene expression. In this work, we test this idea by characterizing repression in vivo and the binding of RNA polymerase in vitro in experiments where operators of various sequences were placed either upstream or downstream from the promoter in Escherichia coli. Surprisingly, we find that operators with a weaker binding affinity can yield higher repression levels than stronger operators. Repressor bound to upstream operators modulates promoter escape, and the magnitude of this modulation is not correlated with the repressor-operator binding affinity. This suggests that operator sequences may modulate transcription by altering the nature of the interaction of the bound transcription factor with the transcriptional machinery, implying a new layer of sequence dependence that must be confronted in the quantitative understanding of gene expression.National Institutes of Health (U.S.) (Grant GM81648)National Institutes of Health (U.S.) (Grant GM43369
Naturalization record of Perez, Adolfo Huarte
No full textThe naturalization certificate for Alvaro Sanchez of Spain. Signed by Judge Barron Phillips
Feedback between Population and Evolutionary Dynamics Determines the Fate of Social Microbial Populations
No full textThe evolutionary spread of cheater strategies can destabilize populations engaging in social cooperative behaviors, thus demonstrating that evolutionary changes can have profound implications for population dynamics. At the same time, the relative fitness of cooperative traits often depends upon population density, thus leading to the potential for bi-directional coupling between population density and the evolution of a cooperative trait. Despite the potential importance of these eco-evolutionary feedback loops in social species, they have not yet been demonstrated experimentally and their ecological implications are poorly understood. Here, we demonstrate the presence of a strong feedback loop between population dynamics and the evolutionary dynamics of a social microbial gene, SUC2, in laboratory yeast populations whose cooperative growth is mediated by the SUC2 gene. We directly visualize eco-evolutionary trajectories of hundreds of populations over 50–100 generations, allowing us to characterize the phase space describing the interplay of evolution and ecology in this system. Small populations collapse despite continual evolution towards increased cooperative allele frequencies; large populations with a sufficient number of cooperators “spiral” to a stable state of coexistence between cooperator and cheater strategies. The presence of cheaters does not significantly affect the equilibrium population density, but it does reduce the resilience of the population as well as its ability to adapt to a rapidly deteriorating environment. Our results demonstrate the potential ecological importance of coupling between evolutionary dynamics and the population dynamics of cooperatively growing organisms, particularly in microbes. Our study suggests that this interaction may need to be considered in order to explain intraspecific variability in cooperative behaviors, and also that this feedback between evolution and ecology can critically affect the demographic fate of those species that rely on cooperation for their survival.Harvard University ("Foundational Questions in Evolutionary Biology” initiative, grant FQEB #RFP-12-07)National Institutes of Health (U.S.) (NIH grant NIH DP2 GM085279-02)National Institutes of Health (U.S.) (NIH grant R00 GM085279-02)National Science Foundation (U.S.) (grant PHY-1055154)Pew Charitable TrustsAlfred P. Sloan Foundatio
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