845 research outputs found
Interleukins and pregnancy: A questioned reality [INTERLEUKINAS Y EMBARAZO: UNA REALIDAD CUESTIONADA]
No full textWe are reviewing information concerning the role of interleukins (ILs) in labor and pregnancy; these substances produce the ignition of the araquidonic acid/prostaglandins cascade to induce labor, this process could be also activated by bacterial lipopolysaccharides in this case we could have preterm labor. The activity and production of IL-2 normally is inhibited, if it does not happen an abortion could result. IL-3 and stimulatory growth factors (SGFs) are implicated in the growth and development of the pregnancy, the alteration in the production of this IL could produce intrauterine growth retardation, both of these ILs are acting in the maternal fetal interphase. We consider it very important that the gynecologists and obstetricians should have more information about ILs related to normal and complicated pregnancy
Interleukins and pregnancy: A questioned reality [INTERLEUKINAS Y EMBARAZO: UNA REALIDAD CUESTIONADA]
No full textWe are reviewing information concerning the role of interleukins (ILs) in labor and pregnancy; these substances produce the ignition of the araquidonic acid/prostaglandins cascade to induce labor, this process could be also activated by bacterial lipopolysaccharides in this case we could have preterm labor. The activity and production of IL-2 normally is inhibited, if it does not happen an abortion could result. IL-3 and stimulatory growth factors (SGFs) are implicated in the growth and development of the pregnancy, the alteration in the production of this IL could produce intrauterine growth retardation, both of these ILs are acting in the maternal fetal interphase. We consider it very important that the gynecologists and obstetricians should have more information about ILs related to normal and complicated pregnancy
Experience with wavefront sensor and deformable mirror interfaces for wide-field adaptive optics systems
No full textEuropean Commission [211257]; OPTICON programme Infrastructures 2008-1 Grant [226604 (JRA1)]; OPTICON programme Infrastructures 2012-1 Grant [312430 (WP1)]Basden, A.G., Atkinson, D., Bharmal, N.A., Bitenc, U., Brangier, M., Buey, T., Butterley, T., Cano, D., Chemla, F., Clark, P., Cohen, M., Conan, J.-M., de Cos, F.J., Dickson, C., Dipper, N.A., Dunlop, C.N., Feautrier, P., Fusco, T., Gach, J.L., Gendron, E., Geng, D., Goodsell, S.J., Gratadour, D., Greenaway, A.H., Guesalaga, A., Guzman, C.D., Henry, D., Holck, D., Hubert, Z., Huet, J.M., Kellerer, A., Kulcsar, C., Laporte, P., Le Roux, B., Looker, N., Longmore, A.J., Marteaud, M., Martin, O., Meimon, S., Morel, C., Morris, T.J., Myers, R.M., Osborn, J., Perret, D., Petit, C., Raynaud, H., Reeves, A.P., Rousset, G., Sanchez Lasheras, F., Sanchez Rodriguez, M., Santos, J.D., Sevin, A., Sivo, G., Stadler, E., Stobie, B., Talbot, G., Todd, S., Vidal, F., Younger, E.J
Connecting People - Blurring the borders between the clinic and the city
No full textGraduation design Rehabilitation Centre RotterdamMSc3/4 Design Rehabilitation CentreInteriors, Buildings and CitiesArchitectur
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference
No full textEndocannabinoid signaling has recently been implicated in ethanol-seeking behavior. We analyzed the expression of endocannabinoid-related genes in key brain regions of reward and dependence, and compared them between the alcohol-preferring AA (Alko Alcohol) and nonpreferring ANA (Alko Non-Alcohol) rat lines. A decreased expression of fatty acid amidohydrolase (FAAH), the main endocannabinoid-degrading enzyme, was found in prefrontal cortex (PFC) of AA rats, and was accompanied by decreased enzyme activity in this region. Binding of the endocannabinoid-cannabinoid 1 (CB1) receptor ligand 3[H]SR141716A, and [35S]GTPitalic gammaS incorporation stimulated by the CB1 agonist WIN 55,212-2 were downregulated in the same area. Together, this suggests an overactive endocannabinoid transmission in the PFC of AA animals, and a compensatory downregulation of CB1 signaling. The functional role of impaired FAAH function for alcohol self-administration was validated in two independent ways. The CB1 antagonist SR141716A potently and dose-dependently suppressed self-administration in AA rats when given systemically, or locally into the PFC, but not in the striatum. Conversely, intra-PFC injections of the competitive FAAH inhibitor URB597 increased ethanol self-administration in nonselected Wistar rats. These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target
Effect of tank volume on the growth and survival of reared Octopus vulgaris paralarvae
No full textCommercial culture of octopus has not yet been achieved due to the high mortality recorded during the first weeks of life. Several researchers have pointed out nutrition as the key factor of influence on paralarval mortality in culture (Iglesias, Sanchez, Bersano, Carrasco, Dhont, Fuentes, Linares, Munoz, Okumura, Roo, van der Meeren, Vidal & Villanueva 2007; Villanueva, Escudero, Deulofeu, Bozzano & Casoliva 2009; Seixas, Rey-Mendez, Valente & Otero 2010; Seixas, Otero, Valente, Dias & Rey-Mendez 2010; Fuentes, Sanchez, Lago, Iglesias, Pazos and Linares 2011). Nevertheless, several other factors, such as culture volume, can influence the success in paralarvae rearing. The lack of a standardized culture technique has meant that some authors have reared paralarvae in relatively large tank volumes: from 20 000 L used by Hamazaki, Fukunaga, Yoshida and Maruyama (1991), 9000 L (Moxica, Linares, Otero, Iglesias & Sanchez 2002), 6000 L (De Wolf, Lenzi & Lenzi 2011) and 1000 L (Iglesias, Otero, Moxica, Fuentes & Sanchez 2004), whereas others have worked with smaller volumes: Villanueva, Koueta, Riba and BoucaudCamou (2002) used 25 L tanks, Carrasco, Arronte & Rodriguez 2006; 30 L and Seixas (2009) 50 L. This study analyses tank volume effect on growth and survival of octopus paralarvae in their first month of life, using enriched artemia as live diet. Protein and lipid composition of paralarvae were also analysed to have an approach to paralarvae condition. Materials and method
Seasonal structure of fish assemblages in rocky and sandy habitats in Bahía de La Paz, Mexico
No full textEcological surveys from several coastal environments in Bahía de La Paz were analysed to determine the seasonal changes in the fish assemblages in the largest bay of the Gulf of California. We identified 58 species from 37 genera and 23 families in seasonal gill net samples were taken over 1 yr. Using the relative abundance index (%N), the most important species were Gerres cinereus, Arius platypogon, Lutjanus guttatus, Haemulon sexfasciatus, Kyphosus elegans, Diapterus peruvianus, Chaetodipterus zonatus, and Nematistius pectoralis. By relative weight (%W) the main species were similar but in a different ranking Kyphosus elegans, L. guttatus, G. cinereus, A. platypogon, Carcharhinus porosus, H. sexfasciatus, and Scomberomorus sierra. Three seasonal species groups were determined and their abundance, richness, and diversity were analyzed. Dissimilarity analysis suggests that were closely three habitats associated with three different fish assemblages inside Bahia de La Paz: (a) an exposed coastal zone with big rocks and sandy beaches; (b) protected coastal estuarine zone with sandy and shallow bottom; and (c) an oceanic island zone with rocky bottom and sandy patches
Seasonal structure of fish assemblages in rocky and sandy habitats in Bahía de La Paz, Mexico
No full textEcological surveys from several coastal environments in Bahía de La Paz were analysed to determine the seasonal changes in the fish assemblages in the largest bay of the Gulf of California. We identified 58 species from 37 genera and 23 families in seasonal gill net samples were taken over 1 yr. Using the relative abundance index (%N), the most important species were Gerres cinereus, Arius platypogon, Lutjanus guttatus, Haemulon sexfasciatus, Kyphosus elegans, Diapterus peruvianus, Chaetodipterus zonatus, and Nematistius pectoralis. By relative weight (%W) the main species were similar but in a different ranking Kyphosus elegans, L. guttatus, G. cinereus, A. platypogon, Carcharhinus porosus, H. sexfasciatus, and Scomberomorus sierra. Three seasonal species groups were determined and their abundance, richness, and diversity were analyzed. Dissimilarity analysis suggests that were closely three habitats associated with three different fish assemblages inside Bahia de La Paz: (a) an exposed coastal zone with big rocks and sandy beaches; (b) protected coastal estuarine zone with sandy and shallow bottom; and (c) an oceanic island zone with rocky bottom and sandy patches
T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects
No full textLipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied. However, neither T-cell epitopes nor their effect on the patients’ T-cell response has been investigated in any member of the LTP panallergen family. The objective of the present study was to map the major T-cell epitopes of Pru p 3, as well as to evaluate their induced T-cell response in peach-allergic versus control subjects. Thus, peripheral blood mononuclear cells (PBMCs) from 18 peach-allergic patients and Pru p 3-specific T-cell lines (TCLs) from 9 of them were cultured with Pru p 3 and with a panel of 17 derived peptides (10-mer overlapping in 5 amino acids representing the full sequence of Pru p 3). Proliferation in 5-day assays was carried out via tritiated-thymidine incorporation, while IL4 and IFNγ production was assessed via sandwich enzyme-linked immunosorbent tests (ELISA) of TCL culture supernatants. The results were compared to those obtained from 10 non-peach allergic control volunteers. Two consecutive peptides showed the highest activation capacity. About 74% of PBMCs and TCLs recognized them, forming a single T-epitope: Pru p 365–80. Additionally, other specific T-cell epitopes were observed. Pru p 325–35 was detected by more than 60% of TCLs from peach-allergic patients, and Pru p 345–55 only activated PBMCs from control subjects. Interestingly, TCLs from patients were associated with a Th2-type, whereas control TCLs presented a Th1-type cytokine response. The major immunogenic T-cell epitope identified in Pru p 3, Pru p 365–80, is a good candidate to develop new vaccines for hypersensitivity reactions associated with LTP allergens from Rosaceae fruits
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