13 research outputs found
Manifestation of fact and document as two independent events in sureyya agaoglu's work “one life has passed just like this”
No full textSureyya Agaoğlu, one of the most important figures in the history of Turkey, wrote a
work entitled “One Life Has Passed Just Like This” is the author's second memoir. It is
interesting that the first female human rights defender Sureyya Agaoğlu's work “One Life Has
Passed Just Like This” written creatively based on the facts of her life, shows the fact and the
document as two independent events. She managed to illuminate not only a certain part of the
writer's own life, but also the lives of other historical figures. Among the historical personalities,
one of the people who attract attention is the narration of the events about the author's father -
Ahmet bey Agaoglu, based on real facts.
In Sureyya Agaoglu's work, the fact from reality acts as a catalyst for literary creativity.
The author's self-reflection encourages the concretization of the genre of the work. Because the
ability of the subject, i.e. the writer, to put the understanding of her personal thoughts about the
realities, as well as his activity, into the form of a rich prose, draws attention to the genre of the
work. The work written by Sureyya Agaoğlu called “One Life Has Passed Just Like This” is
valuable as a work written in the genre of memoirs.
In addition to the plot line based on Sureyya Agaoğlu's life history, she added many
incidents taken from his childhood and youth. In addition to the perfect image of the author, the
images of historical figures (Ataturk, Ahmet Bey Agaoglu, Samad Agaoglu, etc.) whose
services have been invaluable in the blood memory of the people are of interest. Sureyya
Agaoğlu, with his work “One Life Has Passed Just Like This”, who was able to become a
political figure with a unique artistic understanding in the blood memory of the Turkish world,
who was able to become the protector of women and children in the most difficult moments of
his people was able to confirm that she had a lawyer. Sureyya Agaoğlu managed not to lose
author “I” in this work presented to the readers and created a memorable image as an author
The relationship among oral contraceptive use, sleep, and sexual behavior
No full textThe purpose of this study was to discover if individuals taking oral contraceptives differed on measures of sleep and sexual behavior compared to those who are taking no form of birth control. Participants wore motion loggers every night for two-weeks to track their sleep and filled out a questionnaire every morning asking them about their sleep, sexual feelings, sexual behavior, and affect from the day before. Research in this area of study is very sparse and results are conflicting, therefore we aimed to obtain comprehensive information to derive a basic understanding on if sexual behavior variables and sleep variables are in fact related and the extent to which oral contraceptive use impacts either. Although the literature demonstrated inconsistent and conflicting findings that often lacked the inclusion of female participants focusing on the impact of estrogen and progesterone on sleep and sexual behavior, it is anticipated that during the mid-follicular phase of the menstrual cycle, when estrogen is known to increase, participants will demonstrate better sleep outcomes, greater sexual desire, and increased sexual behavior compared to the mid-luteal phase, when progesterone increases, and the late-luteal phase and menstruation, when estrogen and progesterone dip. Between users and non-users, it is anticipated that scores on the Female Sexual Functioning Index will be higher for users. Focusing on the correlational relationship between variables, it is predicted that measures of the Pittsburg Sleep Quality Index, wake after sleep onset, sleep duration, and sexual desire will be significantly correlated. Results will be discussed during the presentation. Implications of the predicted results could encourage others to critically examine how oral contraceptives are impacting other major life areas aside from reduction of pregnancy risk and additional factors for consumption (e.g. acne, painful periods, heavy bleeding). Furthermore, results should lead to a greater understanding of the relationship and potential impact of commonly prescribed drugs as well as add to the scare literature. This study can encourage others to obtain more information on oral contraceptives and how the addition of exogenous hormones can affect major components of quality of life, such as sleep and sexual behavior
The relationship among oral contraceptive use, sleep, and sexual behavior
No full textThe purpose of this study was to discover if individuals taking oral contraceptives differed on measures of sleep and sexual behavior compared to those who are taking no form of birth control. Participants wore motion loggers every night for two-weeks, tracking their sleep, and filled out a questionnaire every morning inquiring about their sleep, sexual feelings, sexual behaviors, and affect from the day before. Research in this area of study is very sparse and results are conflicting, therefore I aimed to obtain comprehensive information to derive a basic understanding on if sexual behavior variables and sleep variables are in fact related and the extent to which oral contraceptive use impacts either. Results from an independent t-test analyses showed that oral contraceptive users had higher average sexual arousal, average genital lubrication, and average Female Sexual Functioning Index scores than non-users. The oral contraceptive users also demonstrated greater instances of sexual initiation and sexual intercourse than non-users, however, this finding is likely attributed to the discrepancies between groups regarding both partner availability and sexual activity status. Furthermore, average sleep duration was a significant predictor of average orgasmic function, explaining 29% of the total variance. When looking at scores not averaged, Positive and Negative Affect Schedule scores were tested and showed to be a significant predictor of genital lubrication, explaining 13.5% of the total variance. Future directions should aim to examine a more diverse sample of participants to understand the potential influences of race, gender identity, sexual orientation, and chronotype on the test variables
Natural history of depression in traumatic brain injury11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.
No full textInvestigating Pelvic Floor Muscle Strength in Women of Reproductive Age and Factors Affecting It
No full textThis descriptive study was designed to investigate the pelvic floor muscle strength (PFMS) of women aged 18 to 49 years and to examine the factors that may have an effect on PFMS. The study was conducted on 258 women who visited a gynecology outpatient clinic between January 2019 and January 2020, who met the research criteria, and who agreed to participate in the study. The data were collected using the Sociodemographic Characteristics Information Form. The Modified Oxford Scale (MOS) and a perineometer were used to evaluate the PFMS of the women. The mean PFMS value measured using the perineometer was 31.56 +/- 12.17 cmH(2)O (moderate pressure). The PFMS values were 20.00 to 29.9 cmH(2)O (weak pressure) and 30.00 to 39.9 cmH(2)O (moderate pressure) in 23.6% of the women, respectively. The PFMS values measured with MOS were of grade 3 strength (moderate pressure) in 23.6% of the women and grade 2 strength (weak pressure) in 23.3%. A statistically significant strong correlation was found between the perineometer measurement and the women's MOS values. Moreover, a statistically significant difference was found between the PFMS values measured with the perineometer, MOS scores, and women's age groups, educational status, marital status, employment status, income status, persistent cough, use of nicotine, alcohol and coffee consumptions, chronic constipation, history of frequent urinary tract infections, regular exercise, body mass index, history of pregnancy, mode of delivery, use of episiotomy at birth, perineal rupture at birth, use of forceps vacuum at birth, multiple pregnancies, delivery of a baby weighing >= 4,000 g, treatment during pregnancy, hysterectomy, menopause, frequency of sexual intercourse, and pain during sexual intercourse (p < .05). We conclude that most of the women in the study had weak to moderate PFMS, that the evaluation of PFMS with the MOS positively overlapped with the perineometric measurements, and that a number of sociodemographic and obstetric variables act as risk factors that affect PFMS. The PFMS of all women should be assessed as part of their routine gynecological examinations.Ege UniversityEge University [794]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by Ege University Scientific Research Project ID. 794. Written permission was obtained from the Medical Research Ethics Committee of Ege University, where the study was conducted. (Ethics Committee Approval No:17-3/2)
Pathological Computed Tomography Features Associated with Adverse Outcomes after Mild Traumatic Brain Injury
No full textImportance: A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker for acute traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown to be associated with outcomes. In mild TBI (mTBI; GCS scores 13-15), distribution and co-occurrence of pathological CT features and their prognostic importance are not well understood. Objective: To identify pathological CT features associated with adverse outcomes after mTBI. Design, Setting, and Participants: The longitudinal, observational Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study enrolled patients with TBI, including those 17 years and older with GCS scores of 13 to 15 who presented to emergency departments at 18 US level 1 trauma centers between February 26, 2014, and August 8, 2018, and underwent head CT imaging within 24 hours of TBI. Evaluations of CT imaging used TBI Common Data Elements. Glasgow Outcome Scale-Extended (GOSE) scores were assessed at 2 weeks and 3, 6, and 12 months postinjury. External validation of results was performed via the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Data analyses were completed from February 2020 to February 2021. Exposures: Acute nonpenetrating head trauma. Main Outcomes and Measures: Frequency, co-occurrence, and clustering of CT features; incomplete recovery (GOSE scores <8 vs 8); and an unfavorable outcome (GOSE scores <5 vs ≥5) at 2 weeks and 3, 6, and 12 months. Results: In 1935 patients with mTBI (mean [SD] age, 41.5 [17.6] years; 1286 men [66.5%]) in the TRACK-TBI cohort and 2594 patients with mTBI (mean [SD] age, 51.8 [20.3] years; 1658 men [63.9%]) in an external validation cohort, hierarchical cluster analysis identified 3 major clusters of CT features: contusion, subarachnoid hemorrhage, and/or subdural hematoma; intraventricular and/or petechial hemorrhage; and epidural hematoma. Contusion, subarachnoid hemorrhage, and/or subdural hematoma features were associated with incomplete recovery (odds ratios [ORs] for GOSE scores <8 at 1 year: TRACK-TBI, 1.80 [95% CI, 1.39-2.33]; CENTER-TBI, 2.73 [95% CI, 2.18-3.41]) and greater degrees of unfavorable outcomes (ORs for GOSE scores <5 at 1 year: TRACK-TBI, 3.23 [95% CI, 1.59-6.58]; CENTER-TBI, 1.68 [95% CI, 1.13-2.49]) out to 12 months after injury, but epidural hematoma was not. Intraventricular and/or petechial hemorrhage was associated with greater degrees of unfavorable outcomes up to 12 months after injury (eg, OR for GOSE scores <5 at 1 year in TRACK-TBI: 3.47 [95% CI, 1.66-7.26]). Some CT features were more strongly associated with outcomes than previously validated variables (eg, ORs for GOSE scores <5 at 1 year in TRACK-TBI: neuropsychiatric history, 1.43 [95% CI.98-2.10] vs contusion, subarachnoid hemorrhage, and/or subdural hematoma, 3.23 [95% CI 1.59-6.58]). Findings were externally validated in 2594 patients with mTBI enrolled in the CENTER-TBI study. Conclusions and Relevance: In this study, pathological CT features carried different prognostic implications after mTBI to 1 year postinjury. Some patterns of injury were associated with worse outcomes than others. These results support that patients with mTBI and these CT features need TBI-specific education and systematic follow-up..</p
Biomarkers for Traumatic Brain Injury:Data Standards and Statistical Considerations
No full textRecent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.</p
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Effect of frailty on 6-month outcome after traumatic brain injury : a multicentre cohort study with external validation
No full textAbstract: Background Frailty is known to be associated with poorer outcomes in individuals admitted to hospital for medical conditions requiring intensive care. However, little evidence is available for the effect of frailty on patients' outcomes after traumatic brain injury. Many frailty indices have been validated for clinical practice and show good performance to predict clinical outcomes. However, each is specific to a particular clinical context. We aimed to develop a frailty index to predict 6-month outcomes in patients after a traumatic brain injury. Methods A cumulative deficit approach was used to create a novel frailty index based on 30 items dealing with disease states, current medications, and laboratory values derived from data available from CENTER-TBI, a prospective, longitudinal observational study of patients with traumatic brain injury presenting within 24 h of injury and admitted to a ward or an intensive care unit at 65 centres in Europe between Dec 19, 2014, and Dec 17, 2017. From the individual cumulative CENTER-TBI frailty index (range 0-30), we obtained a standardised value (range 0-1), with high scores indicating higher levels of frailty. The effect of frailty on 6-month outcome evaluated with the extended Glasgow Outcome Scale (GOSE) was assessed through a proportional odds logistic model adjusted for known outcome predictors. An unfavourable outcome was defined as death or severe disability (GOSE score = 65 years). The CENTER-TBI frailty index score was significantly associated with the probability of an increasingly unfavourable outcome (cumulative odds ratio [OR] 1.03, 95% CI 1.02-1.04; p<0.0001), and the association was stronger for participants admitted to hospital wards (1.04, 1.03-1.06, p<0.0001) compared with those admitted to the intensive care unit (1.02, 1.01-1.03 p<0.0001). External validation of the CENTER-TBI frailty index in data from the TRACK-TBI (n=1667) cohort supported the robustness and reliability of these findings. The overall median TRACK-TBI frailty index score was 0.03 (IQR 0-0.10), with the frailty index score significantly associated with the risk of an increasingly unfavourable outcome in patients admitted to hospital wards (cumulative OR 1.05, 95% CI 1.03-1.08; p<0.0001), but not in those admitted to the intensive care unit (1.01, 0.99-1.03; p=0.43). Interpretation We developed and externally validated a frailty index specific to traumatic brain injury. Risk of unfavourable outcome was significantly increased in participants with a higher CENTER-TBI frailty index score, regardless of age. Frailty identification could help to individualise rehabilitation approaches aimed at mitigating effects of frailty in patients with traumatic brain injury. Copyright (C) 2022 Published by Elsevier Ltd. All rights reserved
Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohortsResearch in context
No full textSummary: Background: Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and major depressive disorder (MDD) are associated with the development of cognate TBI-related phenotypes. Methods: Meta-analyses were conducted using data from two multicenter, prospective observational cohort studies of patients with mTBI: the CENTER-TBI study (ClinicalTrials.gov ID NCT02210221) in Europe (December 2014–December 2017) and the TRACK-TBI study in the US (March 2014–July 2018). In both cohorts, the most common causes of injury were road traffic accidents and falls. Primary outcomes, specifically probable PTSD and depression, were defined at 6 months post-injury using scores ≥33 on the PTSD Checklist-5 and ≥15 on the Patient Health Questionnaire-9, respectively. We calculated PTSD-PRS and MDD-PRS for patients aged ≥17 years who had a Glasgow Coma Scale score of 13–15 upon hospital arrival and assessed their association with PTSD and depression following TBI. We also evaluated the transferability of the findings in a cohort of African Americans. Findings: Overall, 11.8% (219/1869) and 6.7% (124/1869) patients were classified as having probable PTSD and depression, respectively. The PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30–1.84, p < 0.001, I2 = 20.8%]. Although the MDD-PRS increased the risk of depression after TBI, it did not reach significance in the individual cohorts. However, in a combined analysis, the risk was significantly elevated with a pooled OR of 1.26 [95% CI 1.03–1.53, p = 0.02, I2 = 0%]. The addition of PRSs improved the proportion of outcome variance explained in the two study cohorts from 19.5% and 30.3% to 21.6% and 34.0% for PTSD; and from 11.0% and 22.5% to 12.8% and 22.6% for depression. Patients in the highest cognate PRS quintile had increased odds of 3.16 [95% CI 1.80–5.55] and 2.03 [95% CI 1.04–3.94] of developing PTSD or depression compared to the lowest quintile, respectively. Interpretation: Associations of PRSs with PTSD and depression following TBI are not disorder-specific. However, the overlap between MDD-PRS and depression following TBI is less robust compared to PTSD-PRS and PTSD. PRSs could improve risk prediction, and permit enrichment for interventional trials. Funding: This study was supported by funding by an FP7 grant from the European Union, Hannelore Kohl Stiftung, Integra LifeSciences Corporation, NeuroTrauma Sciences, US National Institutes of Health, US Department of Defense, National Football League Advisory Board, US Department of Energy, and One Mind
