1,721,506 research outputs found
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
Get PDFThe molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
Get PDFThe molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Cenotafio al cansancio : un memorial al deseo de recuperarse
No full textFil: García Vieyra, Milagros. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Sanchez Martin, Eva Agustina. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.El presente trabajo es el resultado de meses de labor en conjunto, nacido de una idea entre charlas y conversaciones de clínica artística durante la materia Seminario de Trabajo Final, a cargo del docente titular Lucas Di Pascuale. Esta materia, una que incluye a todas las especialidades, fue la oportunidad perfecta para coincidir debido a que las autoras de esta tesis pertenecemos a diferentes especializaciones dentro de la carrera de Artes Visuales. Por un lado, Eva Agustina Sanchez Martin se formó con una inclinación por el área de Pintura. Mientras que Milagros García Vieyra, por el otro, concretó su formación en el área de Grabado.
Durante estos encuentros de clínica, de cambios y devoluciones en tanto nuestros procesos personales, descubrimos experiencias y sentires compartidos. La primera vez que tradujimos nuestras ideas a una obra fue en el mes de diciembre de 2022, en la sala Jorge Díaz del Pabellón Bolivia, Facultad de Artes, Universidad Nacional de Córdoba. Allí consideramos el comienzo de nuestras primeras aproximaciones a lo que este trabajo es hoy.
Otra cosa que compartimos era el deseo de vehiculizar esas ideas en algo tangible, que no quedaran solamente en el plano del pensamiento. Fue entonces cuando las experimentaciones, propias y en conjunto consecuentemente, comenzaron a surgir. De estos precedentes contaremos brevemente a continuación.
Si bien una de nosotras ya estaba trabajando en el plano de esta temática, no fue hasta la fecha antes mencionada que comenzamos a trabajar en conjunto. En esos momentos llevamos a cabo un diálogo entre expresiones artísticas, el montaje de obra gráfica y la performance, con un punto de inflexión común. Este estaba conformado por nociones cercanas a perturbaciones cognitivas, pensamientos intrusivos y sentimientos abrasivos, en contraste con un vacío espacial intencional, dado por el espacio tan especial que generaba la sala elegida.Fil: García Vieyra, Milagros. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina.Fil: Sanchez Martin, Eva Agustina. Universidad Nacional de Córdoba. Facultad de Artes. Departamento Académico de Artes Visuales; Argentina
The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
Get PDFMitochondria can receive, integrate, and transmit a variety of signals to shape many biochemical activities of the cell. In the process of tumor onset and growth, mitochondria contribute to the capability of cells of escaping death insults, handling changes in ROS levels, rewiring metabolism, and reprograming gene expression. Therefore, mitochondria can tune the bioenergetic and anabolic needs of neoplastic cells in a rapid and flexible way, and these adaptations are required for cell survival and proliferation in the fluctuating environment of a rapidly growing tumor mass. The molecular bases of pro-neoplastic mitochondrial adaptations are complex and only partially understood. Recently, the mitochondrial molecular chaperone TRAP1 (tumor necrosis factor receptor associated protein 1) was identified as a key regulator of mitochondrial bioenergetics in tumor cells, with a profound impact on neoplastic growth. In this review, we analyze these findings and discuss the possibility that targeting TRAP1 constitutes a new antitumor approach
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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