1,720,973 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
pinellolab/CRISPRme: release with improved memory usage and stability
No full textimproved used of memory during variant analysis
improved stability due to memory usage
solved problem with visualization of reference and alternative targets due to score correction
introduced more graphs and multiple statistics calculated at runtime with different criteria (CFD,CRISTA,mmbul
Personal genome editing algorithms to identify increased variant-induced off-target potential
Get PDFClustered regularly interspaced short palindromic repeats (CRISPR) technologies allow for facile genomic modification in a site-specific manner. A key step in this process is the in-silico design of single guide RNAs (sgRNAs) to efficiently and specifically target a site of interest. To this end, it is necessary to enumerate all potential off-target sites within a given genome that could be inadvertently altered by nuclease-mediated cleavage. Off-target sites are quasi-complementary regions of the genome in which the specified sgRNA can bind, even without a perfect complementary nucleotides sequence. This problem is known as off-target sites enumeration and became common after discovery of CRISPR technology. To solve this problem, many in-silico solutions were proposed in the last years but, currently available software for this task are limited by computational efficiency, variant support, genetic annotation, assessment of the functional impact of potential off-target effects at population and individual level, and a user-friendly graphical interface designed to be usable by non-informatician without any programming knowledge. This thesis addresses all these topics by proposing two software to directly answer the off-target enumeration problem and perform all the related analysis. In details, the thesis proposes CRISPRitz, a tool designed and developed to compute fast and exhaustive searches on reference and alternative genome to enumerate all the possible off-target for a user-defined set of sgRNAs with specific thresholds of mismatches (non-complementary bps in RNA-DNA binding) and bulges (bubbles that alters the physical structure of RNA and DNA limiting the binding activity). The thesis also proposes CRISPRme, a tool developed starting from CRISPRitz, which answers the requests of professionals and technicians to implement a comprehensive and easy to use interface to perform off-target enumeration, analysis and assessment, with graphical reports, a graphical interface and the capability of performing real-time query on the resulting data to extract desired targets, with a focus on individual and personalized genome analysis
samuelecancellieri/plot_generation_CRISPRme: final_release_plot_CRISPRme
No full textrepo to generate CRISPRme plots for pape
pinellolab/CRISPRme: update to stability
No full textImproved general stability
fixed bug in integration resul
CRISPRme Dataset
No full textCRISPRme dataset used to generate data, reports and figures in CRISPRme pubblicatio
pinellolab/CRISPRme: merge from other repo
No full textmerge from personal repo
fixed search with transcriptome
improved stability and controls
integrated different score in website visualization
introduced many more data and graphic
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