50 research outputs found
ENDOMETRIOSIS OF THE ABDOMINAL WALL, TWO OBSERVATIONS AND LITERATURE REVIEW
No full textOuakasse Samira*, Erhaymini Khalil, Jeraf Narjiss, Aicha Driouech, Adib Filali, Mohammed Hassan Alami and Rachid Beza
A Look at the Condition of Women in Malentendues by Azza Filali
No full textA Look at the Female Condition in Malentendues by Azza Filali
This article analyzes the female condition through the central character of Malentendus by Azza Filali. It explores the tensions between social injunctions and individual aspirations, highlighting how the author constructs a female figure striving for emancipation in a Tunisian context marked by deep contradictions. The study examines the narrative and discursive strategies that reveal the obstacles, resistances, and ambiguities shaping the character’s journey. Adopting a literary and socio-critical approach, this article investigates the representation of power dynamics and identity issues in the novelCe travail propose une analyse de la condition féminine à travers le personnage central de Malentendues d’Azza Filali. Il s’agit d’explorer les tensions entre injonctions sociales et aspirations individuelles, mettant en avant la manière dont la romancière présente une figure féminine en quête d’émancipation dans un contexte tunisien marqué par des contradictions majeures. L’article examine les stratégies narratives et discursives qui révèlent les obstacles, les résistances et les ambiguïtés du parcours de ce personnage. En adoptant une approche sociocritique, ce travail interroge la représentation des rapports de pouvoir et des dynamiques identitaires à l’œuvre dans le roman
Development and study of the efficacy of an innovative hospital preparation for the treatment of chronic articular diseases
No full textLes synoviocytes jouent un rôle crucial dans la pathogénèse des maladies articulaires chroniques, et particulièrement dans la phase de destruction ostéoarticulaire en devenant résistants à l’apoptose. Une première étude a mise en évidence une efficacité antiproliférative du cadmium minéral sur ces synoviocytes. Une preuve de concept d’un nouveau produit thérapeutique intra-articulaire à base de cadmium a été élaborée. Cette préparation pharmaceutique innovante, développée pour éviter la dissémination du cadmium minéral dans l’organisme, contenait des nanoparticules à base de cadmium, administrable sous forme liquide à température ambiante et se gélifiait à la température corporelle, en formant des micelles contenant des nanoparticules, ne traversant ainsi pas la cavité synoviale. Initialement, la reproductibilité de l’effet antiprolifératif du cadmium entre la forme minérale et les nanoparticules a été vérifiée dans un modèle in vitro de synoviocytes humains atteints de polyarthrites rhumatoïdes. Une captation différente des nanoparticules selon l’environnement inflammatoire ou pathologique des synoviocytes a été ensuite expliquée par la modification accrue de leurs morphologies. Similairement, l’effet de l’inflammation sur les propriétés physiques des vésicules, sécrétées par les synoviocytes, ont consolidé le choix des caractéristiques de la formulation. Les essais sur des modèles d’arthrite chez le rat ont permis de démontrer l’efficacité de cette nouvelle préparation originale, facilement injectable en intra-articulaire, en réduisant les scores cliniques avec une unique injection. Cette thérapie locale peut être une technique rapide et réalisable en ambulatoireSynoviocytes play a crucial role in the pathogenesis of chronic joint diseases, particularly in the osteoarticular destruction phase by becoming resistant to apoptosis. A first study has demonstrated an antiproliferative efficacy of cadmium mineral on these synoviocytes. A proof of concept of a new intra-articular cadmium-based therapeutic product has been developed. This innovative pharmaceutical preparation, developed to prevent the spread of mineral cadmium in the body, contained cadmium-based nanoparticles, which can be administered in liquid form at room temperature and gelled at body temperature, forming micelles containing nanoparticles, thus crossing the synovial cavity. Initially, the reproducibility of the antiproliferative effect of cadmium between the mineral form and the nanoparticles was verified in an in vitro model of human synoviocytes with rheumatoid arthritis. A different uptake of nanoparticles according to the inflammatory or pathological environment of synoviocytes was then explained by the massive modification of their morphologies. Similarly, the effect of inflammation on the physical properties of the vesicles, secreted by synoviocytes, consolidated the choice of the characteristics of the formulation.Tests on arthritis models in rats have demonstrated the effectiveness of this new original preparation, easily injectable intra-articular, reducing clinical scores with a single injection. This local therapy can be a quick technique and achievable in outpatien
Interactions entre cellules et facteurs solubles dans les maladies articulaires chroniques : compréhension et ciblage thérapeutique
No full textSynoviocytes play a crucial role in the pathogenesis of chronic joint diseases, particularly in the osteoarticular destruction phase by becoming resistant to apoptosis. A first study has demonstrated an antiproliferative efficacy of cadmium mineral on these synoviocytes. A proof of concept of a new intra-articular cadmium-based therapeutic product has been developed. This innovative pharmaceutical preparation, developed to prevent the spread of mineral cadmium in the body, contained cadmium-based nanoparticles, which can be administered in liquid form at room temperature and gelled at body temperature, forming micelles containing nanoparticles, thus crossing the synovial cavity. Initially, the reproducibility of the antiproliferative effect of cadmium between the mineral form and the nanoparticles was verified in an in vitro model of human synoviocytes with rheumatoid arthritis. A different uptake of nanoparticles according to the inflammatory or pathological environment of synoviocytes was then explained by the massive modification of their morphologies. Similarly, the effect of inflammation on the physical properties of the vesicles, secreted by synoviocytes, consolidated the choice of the characteristics of the formulation.Tests on arthritis models in rats have demonstrated the effectiveness of this new original preparation, easily injectable intra-articular, reducing clinical scores with a single injection. This local therapy can be a quick technique and achievable in outpatientLes synoviocytes jouent un rôle crucial dans la pathogénèse des maladies articulaires chroniques, et particulièrement dans la phase de destruction ostéoarticulaire en devenant résistants à l’apoptose. Une première étude a mise en évidence une efficacité antiproliférative du cadmium minéral sur ces synoviocytes. Une preuve de concept d’un nouveau produit thérapeutique intra-articulaire à base de cadmium a été élaborée. Cette préparation pharmaceutique innovante, développée pour éviter la dissémination du cadmium minéral dans l’organisme, contenait des nanoparticules à base de cadmium, administrable sous forme liquide à température ambiante et se gélifiait à la température corporelle, en formant des micelles contenant des nanoparticules, ne traversant ainsi pas la cavité synoviale. Initialement, la reproductibilité de l’effet antiprolifératif du cadmium entre la forme minérale et les nanoparticules a été vérifiée dans un modèle in vitro de synoviocytes humains atteints de polyarthrites rhumatoïdes. Une captation différente des nanoparticules selon l’environnement inflammatoire ou pathologique des synoviocytes a été ensuite expliquée par la modification accrue de leurs morphologies. Similairement, l’effet de l’inflammation sur les propriétés physiques des vésicules, sécrétées par les synoviocytes, ont consolidé le choix des caractéristiques de la formulation. Les essais sur des modèles d’arthrite chez le rat ont permis de démontrer l’efficacité de cette nouvelle préparation originale, facilement injectable en intra-articulaire, en réduisant les scores cliniques avec une unique injection. Cette thérapie locale peut être une technique rapide et réalisable en ambulatoir
Interpolation sets and the size of quotients of function spaces on a locally compact group
Get PDFWe devise a fairly general method for estimating the size of quotients between algebras of functions on a locally compact group. This method is based on the concept of interpolation sets and unifies the approaches followed by many authors to obtain particular cases.
Among the applications we find, we obtain that the quotients WAP(G)/B(G) (G being a locally compact group in the class [IN] or a nilpotent locally compact group) and CB(G)/LUC(G) (G being any non-compact non-discrete locally compact group) contain a linearly isometric copy of \ell_\infty(\kappa(G)) where \kappa(G) is the compact covering number of G, and WAP(G), B(G) and LUC(G) refer, respectively, to the algebra of weakly almost periodic functions, the uniform closure of the Fourier-Stieltjes algebra and the bounded right uniformly continuous functions.The research of the second author was partially supported by the Spanish Ministry of Science (including FEDER funds), grant MTM2011-23118 and Fundació Caixa Castelló-Bancaixa, grant number P11B2014-35
Evaluation des pratiques de prescription des sérologies et des charges virales du virus Epstein-Barr chez les greffés de rein et de cellules souches hématopoïetiques aux hopitaux universitaires de Strasbourg
No full textSTRASBOURG ILLKIRCH-Pharmacie (672182101) / SudocSudocFranceF
The root essential oil from the Tunisian endemic plant Ferula tunetana: Chemical composition, biological evaluation, molecular docking analysis and drug-likeness prediction
No full textOxidative stress is closely related to cancer aspects, such as the induction of gene muta-tions resulting from cellular injury and the effects on transcription and signal transduction factors. In addition, antibiotic resistance is also linked with oxidative stress, which could contribute to the selection of resistant bacterial strains. With this in mind, and considering that essential oils are well known to display antioxidant, antimicrobial, and cytotoxic activities, this study was destined to in-vestigate the chemical composition and to screen these properties for the root essential oil (REO) of the Tunisian endemic species Ferula tunetana Pomel ex Batt. The REO GC/MS analysis led to the identification of nine compounds, representing 94.5% of the total oil composition. The phytochem-ical profile of this essential oil (EO) was characterized by the dominance of sesquiterpenes, compris-ing 11.7% of sesquiterpene hydrocarbons and 82.8% of oxygenated sesquiterpenes. The three major constituents of the EO were caryophyllene oxide (33.9%), a-cyperone (13.9%), and 14-hydroxy-9- epi-(E)-caryophyllene (12.3%). REO showed a good antioxidant potential against DPPH (IC50 = 30.13 & PLUSMN; 0.28 & mu;g/mL), O2 & BULL;- (IC50 = 42.87 & PLUSMN; 0.81 & mu;g/mL) and H2O2 (IC50 = 48.03 & PLUSMN; 1.21 & mu;g/mL). Additionally, the antimicrobial activity results showed that REO had a strong an-tibacterial potential against all target microbial strains, including five Gram-negative, six Gram-positive bacteria, and two Candida species (MICs = 0.039-0.625 mg/mL). Furthermore, the ex-tracted EO was found to have good cytotoxic properties against five human cell lines viz. HT-29, HCT-116, HeLa, A549 and U937, with IC50 values ranging from 3.37 & PLUSMN; 0.02 to 46.66 & PLUSMN; 1.22 & mu;g/mL. The main REO constituents were docked to the human DNA topoisomerase IIa en-zyme and the in vitro cellular toxicities were rationalized. The drug-likeness of the main compounds identified in the studied EO was predicted. Overall, the results of the current study prove that the EO of F. tunetana roots has a noteworthy antioxidant potential and represents an interesting can-didate to treat infectious diseases and cancer. & COPY; 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots
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Extreme non-Arens regularity of the group algebra
Get PDFThe Banach algebras of Harmonic Analysis are usually far from being Arens regular and often turn out to be as irregular as possible. This utmost irregularity has been studied by means of two notions: strong Arens irregularity, in the sense of Dales and Lau, and extreme non-Arens regularity, in the sense of Granirer. Lau and Losert proved in 1988 that the convolution algebra L1(G) is strongly Arens irregular for any infinite locally compact group. In the present paper, we prove that L1(G) is extremely non-Arens regular for any infinite locally compact group. We actually prove the stronger result that for any non-discrete locally compact group G, there is a linear isometry from L∞(G) into the quotient space L∞(G)/F(G), with F(G) being any closed subspace of L∞(G) made of continuous bounded functions. This, together with the known fact that ℓ∞(G)/WAP(G) always contains a linearly isometric copy of ℓ∞(G), proves that L1(G) is extremely non-Arens regular for every infinite locally compact grou
