100,582 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation
No full textImmunotherapy with allodepleted donor T-cells improves immune reconstitution after
haploidentical SCT, but infection and leukaemic relapse remain problematic. To develop a
rational approach to refining allodepletion, we characterized the expression of surface markers
and cytokines on proliferating alloreactive T-cells flow cytometrically. CD25 was expressed
on 83 % of CFSE-dim alloreactive T-cells, confirming this as an excellent target for
allodepletion. 70 % of the alloreactive CD25-ve population expressed CD71, identifying this as
a novel marker to target alloreactive T-cells that persist after CD25 depletion. We compared
residual alloreactivity to host or 3rd party after CD25 vs combined CD25/71 immunomagnetic
depletion in 8 HLA-mismatched donor-recipient pairs. In 1o MLRs, residual responses to host
were undetectable after CD25/71 depletion. In 2o MLRs, CD25/71 depletion resulted in
significantly lower residual proliferative response to host than CD25 depletion (median 4.8%
of the response of unmanipulated PBMC vs 9.9%, p < 0.01). Likewise, the median residual
reactivity to host in IFN-γ ELISPOT assays was significantly lower after combined CD25/71
than CD25 allodepletion (14.1 % vs 54.6%, p < 0.05). Third party responses after CD25/71
allodepletion were equivalent to unmanipulated PBMCs in both assays. In pentamer and IFN-γ
ELISPOT assays, anti-viral responses to CMV, EBV and adenovirus were preserved after
combined CD25/71 allodepletion. Finally, we showed that CD25/71 allodepleted T-cells can
be redirected to recognize and secrete IFN-γ and granzyme B in response to CD19 cell lines
and primary ALL blasts through lentiviral transfer of a chimeric αCD19ζ TCR. This strategy
may facilitate immunotherapy with larger doses of allodepleted T-cells after haplo-SCT,
enhancing graft versus leukaemia and anti-viral effects
Network planning guidelines for DVB-T network rollout in Sri Lanka
No full textA dissertation submitted to the Department of Electronic and Telecommunication Engineering for the MSc in TelecommunicationThere has been a clear prospect internationally for some years that existing analogue
television broadcasting will be replaced by digital transmissions. Terrestrial digital
broadcasting offers a range of benefits in comparison to terrestrial analogue
broadcasting such as efficient spectrum utilization, improved audio & video quality,
portable & mobile reception capability etc. Sri Lanka being a developing country it is
high time to make timely entry to digital broadcast era, through establishment of
requisite infrastructure with a view to future dividends derivable from an advanced
digital infrastructure.Therefore the first section of this research discuss the inherent technical strengths of
digital terrestrial broadcasting and analyse candidate technology standards in digital
video broadcasting. further it propose the most suitable technology standard for DTT
rollout in Sri Lanka by analysing technical capabilities as well as degree of
compatibility with existing analog broadcast technology deployed in Sri LankaThe second section discuss the methodology for network planning, by proposing a set
of guidelines for efficient planning of digital video broadcast networks to achieve
nationwide coverage & thereby full access to viewers without any interruption during
DVB-T rollout by specifically analysing Sri Lankan deployment scenarios. Further it
has discussed various propagation models suitable for DVB-T network planning &
step by step guidelines for in-depth coverage estimations & network simulations by
optimizing DVB-T system parameters.
The final section of this research has in detail discussed DVB-T network
implementation issues in practical point of view by critically analysing factors such as
co-location of analog & digital transmission infrastructures, interference issues &
primary distribution architectures. Finally it provides set of recommendations, wherebroadcast network operators can follow when deploying DVB-T networks in SriLanka
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
An Iterative capacity dimensioning scheme for an LTE advanced network under resource constraints
No full textSince the need for high-speed broadband services is growing exponentially, legacy voice oriented networks are now becoming obsolete. Due to the unceasing demand for data, investors of mobile service providing companies are also keener on investing new technologies other than GSM, which ultimately improves spectrum efficiency and speeds up the access. Long Term Evolution (LTE) is the fastest and latest broadband technology with widespread global development of commercial networks. Until now, scientists are working to improve the communication capabilities while evolving from basic voice services to high definition video streaming and real time video game playing. However, every operator has a limited investment capacity and are highly concerned about the maximum utilization of resources with a higher ROI. As a result, it is imperative to have a properly dimensioned and well-optimized network.
However, LTE network dimensioning is not as easy as legacy pure voice-only networks (circuit switched), which can be easily modeled by Erlang formulae. LTE networks are evolving from circuit switching to packet switching; therefore, both voice and data will be transferred as packets. There can be combinations of different data service requirements such as streaming, browsing, interactive video, gaming etc. with voice. In fact, different types of traffic, which require different QoS are inherent. With the new releases of LTE standards, researchers all over the world are interested in finding most optimum ways of dimensioning LTE networks. Several perspectives have looked at calculating the required number of 4G sites in the initial network-planning phase. Even though there are quality-based models, coverage based models, capacity based models and hybrid models already, due to the complexity of both UL and DL throughput calculations, each model has its own advantages and disadvantages. None of the approaches are discussing about an iterative capacity dimensioning solution to fine tune the required site count. Therefore, in this research thesis author proposes an iterative method under constraints to find the minimum site count while achieving given UL/DL speed requirements for LTE network rollouts. This method will be based on iterations, and varying parameters will be heavily significant in the context of DL and UL throughput
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