101,909 research outputs found
Informetrics on M. N. Srinivas
No full textM. N. Srinivas, the well known sociologist is widely recognised as architect of modern Indian sociology and social anthropology. His publications have been analysed by year, domain, authorship pattern, channels of communication used. Keywords, etc. The results indicate that the papers published by him are of a nature that qualify him to be a 'role model' for the younger generations to emulate.
By the end of 1995, Srinivas had to his credit 144 papers which, included 33 broad papers in sociology and anthropology; 18 papers in social change; 28 papers in village studies; 12 papers on religion; 17 papers on caste and 36 papers of general popular interest. The periods 1958-61 and 1974-77, when Srinivas was 38-41 and 58-61 years old. were his most productive periods with highest publication activity
Kaltfließpressen verzahnter Komponenten in einem modifizierten Samanta-Verfahren : Konferenzbericht
No full textCold forging of toothed components by extrusion is associated with high punching forces and tool loads, which requires the use of expensive and high-strength tool steels. High process forces result into a substantial tool deflection, which significantly reduces the precision of the toothed components. Thus, the development of alternative processes in order to reduce acting process forces in cold forging is of high interest. A potential process enhancement approach is to use a preform operation where the resulting preform can be formed partwise either in the same or in a subsequent die. Preforms allow to systematically control the material flow in subsequent forming operations. For this reason, the Institute for Metal Forming Technology in Stuttgart has developed a new cold extrusion process for manufacturing toothed components based on the conventional Samanta process. The newly developed die design of the Guided Material Flow-Samanta (GMF-Samanta) process enables efficient cold forging of gears. By means of numerical simulations and forging experiments it was successfully demonstrated that the new Guided Material Flow-Samanta process results into a significant reduction of punch force and normal pressure while simultaneously improving the die filling.Projekt DEA
T-regulatory cells require Sin3a for stable expression of Foxp3
No full textHistone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory factors. Sin3a has been well established as a Hdac1/2 cofactor, while its role within Tregs has not been established. In this study, the effects of conditional deletion of Sin3a within Foxp3+ Tregs were evaluated. Developmental deletion of Sin3a from Foxp3+ Tregs resulted in the rapid onset of fatal autoimmunity. Treg numbers were greatly reduced, while residual Tregs had impaired suppressive function. Mice also showed effector T-cell activation, autoantibody production, and widespread tissue injury. Mechanistically, Sin3a deletion resulted in decreased transcription of Foxp3 with a complete lack of CNS2 CpG demethylation. In addition, Foxp3 protein stability was impaired with an increased ex-Treg population. Thus, Sin3a plays a critical role in the maintenance of Treg identity and function and is essential for the expression and stability of Foxp3
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Asynchronous field-induced ferromagnetism of the two Fe sub-lattices in (Hf,Ta)Fe2: Emergence of an additional first-order phase transition
No full textSamanta T, Wiesekopsieker S, Taake C, Caron L. Asynchronous field-induced ferromagnetism of the two Fe sub-lattices in (Hf,Ta)Fe2: Emergence of an additional first-order phase transition. APL Materials. 2025;13(3): 031112.The field-induced change of the magnetic phase transitions in partially Ta-substituted Hf0.84Ta0.16Fe2 has been examined by combining dc-magnetization, ac-susceptibility, magnetoresistance, and analysis of the isothermal entropy change [Delta S infinity (mu H-0)(n)] field-exponent (n). The system exhibits a first-order magnetic transition (FOMT) from a ferromagnetic (FM) to an antiferromagnetic (AFM) state at T-C (262 K) and a second-order AFM to paramagnetic (PM) transition at T-N (323 K) for lower applied field mu H-0 = 0.1 T. The shift of T-C and T-N follows opposite trends with increasing mu H-0 as expected for this material class. However, a field-induced FOMT has been observed associated with T-N above 2 T, as confirmed by the negative slope of the inverse Arrott plot, the phase transition peak in ac-susceptibility, a slope change in isothermal magnetoresistance, and an overshoot of n greater than 2. The result can be ascribed to the asynchronous field-induced FM ordering of adjacent antiferromagnetically coupled 6h Fe sub-lattices at T-N, which results in the increase of the temperature range of the FOMT. (c) 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license(https://creativecommons.org/licenses/by/4.0/)
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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