273 research outputs found
Interventions for cutaneous sarcoidosis
No full textThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the clinical effectiveness of interventions for cutaneous sarcoidosis
Author Correction: Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
No full textThe originally published version of this article contained an error in the spelling of the author Pankaj Tailor, which was incorrectly given as Pankaj Taylor. This has now been corrected in both the PDF and HTML versions of the article.</jats:p
Correction: Corrigendum: Lipid-II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization
No full textScientific Reports 6: Article number: 37908; published online: 29 November 2016; updated: 10 February 2017. The original version of this Article contained an error in the spelling of the author Pankaj Ror which was incorrectly given as Pankaj Kumar. This has now been corrected in the PDF and HTML versions of the Article.</jats:p
LSE Lit Fest 2017 book review: age of anger: a history of the present by Pankaj Mishra
No full textHow can we explain the apparent rise in hatred in societies around the world? In Age of Anger: A History of the Present, Pankaj Mishra offers a take on our current predicament by tracing increased disaffection, disappointment and disillusionment back through to the eighteenth century. Packed with references drawn from various disciplines and eras, this is a book whose insights deserve thorough contemplation as we search for answers to our ‘age of anger’, writes Kate Bailey. On Tuesday 14 February 2017, author Pankaj Mishra spoke about Age of Anger for the LSE Space for Thought Literary Festival 2017. This year’s theme is Revolutions – not only marking the centenary of the Russian Revolution, but also other anniversaries of revolutions in literature, international relations, politics, religion and science. Tickets to all events are free and available here
Applicability of the Cutaneous Lupus Erythematous disease Area and Severity Index (CLASI) in patients with Systemic Lupus Erythematosus (SLE)
No full textINTRODUCTION :
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune connective
tissue disorder with a wide range of clinical features. Dermatological manifestations are
among the most frequent presenting signs and remain a major source of disease flares
throughout the course of the illness. Assessment of activity of and damage caused by
cutaneous disease is essential from research as well as practice point of view. Most of the
indices for systemic activity assessment include cutaneous manifestations as one of the
components. In 2005, an exclusive index for the cutaneous disease named CLASI
(Cutaneous lupus area and severity index) was formulated and applied to research.
CLASI assesses the activity of and damage caused by cutaneous lupus erythematosus and
has so far been applied to only LE specific lesions. Any given LE patient may manifest
more than one type of LE-specific skin lesion, but, in most patients one form of LEspecific
skin involvement predominates.
The uniqueness of CLASI lies in its ability to separate damage and activity as
such a distinction is essential in any disease that can cause severe persistent organ
damage.
Systemic activity of lupus can be assessed by numerous indices of which SLEDAI
(Systemic Lupus Erythematosus Disease Activity Index) is the simplest tool to use . It
grades the activity of the disease from “no activity” to “very high activity”. Patients with
LE-nonspecific skin manifestations have significantly increased disease activity
compared to those with only LE-specific lesions.5
AIMS & OBJECTIVES :
1. To study the applicability of Cutaneous Lupus Erythematosus Disease Area and Severity index (CLASI) in specific lesions of cutaneous lupus erythematosus
occurring in SLE patients in our population.
2. To assess the disease activity of patients with Systemic Lupus Erythematosus (SLE) and skin lesions using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
3. To correlate SLEDAI with CLASI activity score in SLE patients with Lupus Erythematosus (LE) specific skin lesions.
PATIENTS AND METHODS :
The study was conducted from 1st May 2007 to 30th August 2008 (16 months). It was a prospective, cross sectional study done in the Department of Dermatology, Venereology and Leprosy. The subjects were those attending the outpatient department and inpatients referred to us from the Medical, Pediatrics and rheumatology units.
Inclusion Criteria:
1. All patients with systemic lupus erythematosus having lupus specific and nonspecific lesions.
Exclusion Criteria:
1. Patients without a cutaneous manifestation of LE.
2. Patients not willing to be included.
3. Neonatal lupus.
Ninety-three patients with a diagnosis of SLE according to the 1997 modification of ARA criteria 14 (Appendix D) were included in the study. Three patients were excluded as they were subsequently diagnosed to have mixed connective tissue disease.
Patients were examined by the principal investigator. A detailed proforma was filled (Appendix E). The demographic data included age, address, gender and occupation.
The presenting mucocutaneous complaints and their respective durations were noted. The body sites affected by lupus specific and non-specific manifestations were recorded. A history of drug intake (corticosteroids, immunosuppressants and hydroxychloroquine) and the topical applications used by the patient in the three months prior to their presentation was noted. Subjects were informed about the purpose of the
study (Appendix F) and informed consent (Appendix G) was obtained. Separate child and adolescent assent forms (Appendices H1 & H2) were used for patients in the age groups of 7- 12 years and 13-17 years respectively. Clinical photographs of lesions were taken after patient consent or parenteral consent in case of children.
RESULTS :
Ninety three patients met the inclusion criteria of the study. Three patients were excluded as they were subsequently diagnosed to have mixed connective tissue disease.
The majority of patients were from West Bengal (40.9%), the southern states of Tamilnadu, Andhra Pradesh and Kerala (29%) and Jharkhand (10.75%). The remaining patients (19.3%) were mostly from the North Eastern and other Indian states and Bangladesh. There were 87 adults (>15 years) and 6 children (≤ 15 years). The mean age of the patients was 29.8±12.73 years (range 5-65). There were 87 females and 6 males. The mean age of males was 28.5±10.46 years (range 13-40) and that of females was 29.9 ±10.46 years (range 5 -65). The male to female ratio was 1:14.5 and 1:5 among adults and children respectively. The most common presenting complaint was alopecia (67 patients; 72%) followed by photosensitivity (64 patients; 68%) and oral ulcers (57 patients; 61%). Skin lesions were the first manifestation in 31 patients (33.3%). The most common site for skin lesions was the face (85%) followed by involvement of the trunk (75%) and the upper limbs (70%).
The mean duration of SLE at presentation was 31.9 months (range 2-228 months; SD 42.11) and the mean duration of skin lesions was 12 months (range 0.25 -84 months; SD 16.20)
CONCLUSIONS :
1. This study has shown that CLASI is an effective tool to assess cutaneous activity and damage of specific lesions of LE. The mean CLASI activity score was 15.6 (range 2 to 39) and the mean damage score was 8.24 (range 1 to 30). The scores seen in our patients were comparable to other studies.
2. The mean CLASI activity scores were higher in those who had higher number of anatomical sites affected and those with SCLE, and ACLE occurring in combination with other specific lesions.
3. The CLASI damage scores correlated with the duration of SLE (p<0.01) and also with the duration of skin lesions (p<0.01).
4. The correlation of CLASI activity score and the SLEDAI score was poor (p=0.16).
5. The mean SLEDAI scores of patients with non-specific lesions were higher than those with specific lesions
Optimising charged Higgs boson searches at the Large Hadron Collider across bb¯W± final states
No full textAbstractIn the light of the most recent data from Higgs boson searches and analyses, we re-assess the scope of the Large Hadron Collider in accessing heavy charged Higgs boson signals in bb¯W± final states, wherein the contributing channels can be H+→tb¯, hW±, HW± and AW±. We consider a 2-Higgs Doublet Model Type-II and we assume as production mode bg→tH−+c.c., the dominant one over the range MH±≥480 GeV, as dictated by b→sγ constraints. Prospects of detection are found to be significant for various Run 2 energy and luminosity options
Isolation and Identification of Crude Triacontanol from Rice Bran Wax
No full textIn present investigation crude triacontanol was isolated and identified from rice bran wax. Triacontanol was isolated by saponification and extraction method. The obtained mixture is crude Triacontanol. It was analyzed by Gas Chromatography (GC) and melting point method. Purity of triacontanol was 13.33%. 1Department of Botany, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.), India; 2Department of Botany, University of Pune, Pune (M.S.), India* Corresponding Author, Email: [email protected] Cite This Article As: Sandhya Jaybhay, Pankaj Chate and Avinash Ade. 2010. Isolation and Identification of Crude Triacontanol from Rice Bran Wax. J. Exp. Sci. 1(2): 26
Damaged Reinforced Concrete Structures in Fire
No full textThis thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: • This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. • A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. • This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. • The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. • When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given
Leadership, Vision, Strategy, and the Art of Publishing in India: An Interview With the Legendary Tejeshwar Singh of Sage Publications (India)
No full textGuru Prakash Prabhakar, Pankaj Saran and Joyce Liddle L. , author
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