177,983 research outputs found
Caldas de Reyes. Puente Bermaña
No full textSen circularNo recto, na marxe inferior dereita: "J. Salgado, Edictor"Letra de imprenta no recto en tinta vermella
Caldas de Reyes. Puente de La Herrería
No full textNo recto, na marxe inferior dereita: "J. Salgado, Edictor"Letra de imprenta no recto en tinta vermella.Resumen: Escena da vida cotiá coa ponte ao fondo
Caldas de Reyes. Puente de la Fábrica
No full textSen circular.No recto, na marxe inferior esquerda: "J. Salgado, Edictor"No recto, letras de imprenta en tinta vermella.Resumen: Vista frontal da Ponte da Fábrica.Fuente de ingreso: Compra
Plínio Salgado: o discurso integralista, a revolução espiritual e a ressurreição da nação
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em História.Neste estudo, discutiremos como Plínio Salgado, durante a Ação Integralista Brasileira (1932-1937), buscou legitimação de seu discurso político no discurso religioso, num pensamento centrado no espiritualismo cristão, onde proclama uma doutrina de redenção, uma "revolução espiritual" onde o lema: "Deus, Pátria e Família" passa a constituir o cotidiano dos "Camisas-verdes"
A new species of the caridean shrimp genus Ogyrides Stebbing, 1914 (Decapoda: Ogyrididae) from the eastern tropical Pacific
No full textAyón-Parente, Manuel, Salgado-Barragán, José (2013): A new species of the caridean shrimp genus Ogyrides Stebbing, 1914 (Decapoda: Ogyrididae) from the eastern tropical Pacific. Zootaxa 3683 (5): 589-594, DOI: 10.11646/zootaxa.3683.5.
Carbohydrate-mediated adhesion in Plasmodium falciparum malaria
No full textCharacterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. g. cerebral malaria and severe anemia. Humoral responses to rosetting epitopes seem to confer protective immunity and we have shown in these studies that individuals living in malaria endemic areas build up age-related humoral responses to rosetting epitopes that parallel the development of clinical immunity. Furthermore, epitopes that mediate the rosetting phenotype appear to be diverse but conserved between distant regions in Africa. We have performed a detailed study of the cell-cell binding mechanisms that govern rosetting. Polysaccharides belonging to the glycosaminoglycan family, especially heparin and heparan sulfate, inhibit rosette formation and treatments of host cells indicate that heparan sulfate-like glycans support adhesion. In addition, the ABO blood group phenotype of the infected host modulates rosetting and blood group A and B antigens have been shown to function as co-receptors to other receptors in rosetting.The parasite-derived adhesion molecule that mediates rosetting has been identified as a Plasmodium falciparum erythrocyte membrane protein I (PfEMP1) variant, a product of the vast family of var genes. PfEMP1 mediates adhesion by interacting with host cell glycan receptors, such as heparan sulfate and blood group A antigen. We have characterized the binding of heparan sulfate and heparin to the rosetting domain of PfEMP1. Important molecular features of oligosaccharides required for optimal binding, such as molecular size (12-mer oligosaccharide chain or larger) and N-sulfation, have thus been identified. In field studies, the heparin-binding phenotype of P. falciparum was found to be more common among patients with severe malaria. Furthermore, the clinical isolates had the ability to adhere to multiple receptors. We have characterized the binding properties of PfEMP1. to multiple host receptors, which may explain the poly-adhesive P. falciparum phenotype associated with severe disease in these studies. The present investigation contributes to the molecular elucidation of virulent adhesive phenotypes in P. falciparum malaria. The identified molecules involved in the cell-cell adherence may serve as targets for prophylactic and therapeutic measures.List of scientific papersI. Barragan A, Kremsner PG, Weiss W, Wahlgren M, Carlson J (1998). Age-related buildup of humoral immunity against epitopes for rosette formation and agglutination in African areas of malaria endemicity. Infect Immun. 66(10):4783-4787. https://pubmed.ncbi.nlm.nih.gov/9746579II. Chen Q, Barragan A, Fernandez V, Sundström A, Schlichtherle M, Sahlén A, Carlson J, Datta S, Wahlgren M (1998). Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. J Exp Med. 187(1):15-23. https://pubmed.ncbi.nlm.nih.gov/9419207III. Barragan A, Spillmann D, Kremsner PG, Wahlgren M, Carlson J (1999). Plasmodium falciparum: molecular background to strain-specific rosette disruption by glycosaminoglycans and sulfated glycoconjugates. Exp Parasitol. 91(2):133-143. https://pubmed.ncbi.nlm.nih.gov/9990341IV. Barragan A, Fernandez V, Chen Q, von Euler A, Wahlgren M, Spillman D. The duffy-binding-like domain 1 of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12-mers for binding. [Submitted]V. Heddini A, Obiero J, Barragan A, Kai O, Wahlgren M, Marsh K. Plasmodium falciparum-infected erythrocytes of children with servere malaria bind to multiple receptors. [Submitted]VI. Chen Q, Heddini A, Barragan A, Fernandez V, Pearce SFA, Wahlgren M. The semi-conserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. [Submitted]VII. Barragan A, Kremsner P, Wahlgren M, Carlson J (2000). Blood group A antigen is a co-receptor in Plasmodium falciparum rosetting. Infection and Immunity. [Accepted] https://pubmed.ncbi.nlm.nih.gov/10768996</p
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Los alumnos esternos del Seminario Conciliar a su digno rector el ilustrísimo Juan Lozano, nuevo Obispo de Palencia
No full textTexto firmado por: "J. Salgado"Mención de responsabilidade tomada de fin de textoTexto fechado en: "Santiago mayo 7 de 1866"Data de fin de texto: "Santiago mayo 7 de 1866
New records of gonodactylids (Crustacea: Stomatopoda: Gonodactylidae) from the Pacific Coast of Mexico with remarks on the morphology of Neogonodactylus lalibertadensis (Schmitt, 1940)
No full textSalgado-Barragán, José, Hendrickx, Michel E., Galván-Villa, Cristian M. (2013): New records of gonodactylids (Crustacea: Stomatopoda: Gonodactylidae) from the Pacific Coast of Mexico with remarks on the morphology of Neogonodactylus lalibertadensis (Schmitt, 1940). Zootaxa 3681 (2): 155-162, DOI: 10.11646/zootaxa.3681.2.
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