1,721,262 research outputs found
Does Pacing Affect Lifetime Pace?: The Elusive Clinical Impact of New Pacemaker Implantation After TAVR
No full textn
Invited commentary.
No full textComment on
Impact of preoperative chronic lung disease on survival after surgical aortic valve replacement. [Ann Thorac Surg. 2013
Balloon pulmonary angioplasty in patients with CTEPH
No full textThe only curative treatment currently available for chronic thromboembolic pulmonary hypertension (CTEPH) is surgical pulmonary endoarterectomy (PEA). However, several patients may have high risk factors for surgery, or a peripheral disease not amenable to surgical treatment; or else a residual pulmonary hypertension after PEA. Balloon pulmonary angioplasty (BPA) was recently developed to offer an alternative treatment for these patients. Extensive data has since confirmed the efficacy and relative safety of this procedure. However, there are several technical issues that have yet to be resolved. In addition, many cardiologists and pneumologists still know very little about the procedure itself and its potential. Exploring the clinical indications and technical aspects of BPA, this book offers a valuable reference guide for all those who would like to introduce or improve a BPA program, and for all those whose work involves treating this complex patient population
New transcatheter strategies for multiple pathologies: a paradigmatic clinical case
No full textPercutaneous transcatheter left atrial appendage occlusion and transcatheter mitral valve repair with the MitraClip system represent new therapeutic strategies for selected patients at high risk for both hemorrhagic and cardioembolic events or with symptomatic heart failure and moderate-to-severe mitral valve regurgitation, respectively. We report the case of an 84-year-old patient with severe degenerative mitral regurgitation hospitalized for a first episode of atrial fibrillation, angina pectoris and heart failure. The patient presented a clinical history of spontaneous cerebral bleeding, severe three-vessel coronary disease and multiple comorbidities that contraindicated a conventional surgical treatment. After an accurate clinical-instrumental evaluation, the local Heart Team indicated a combined procedure of percutaneous left atrial appendage closure and transcatheter mitral valve repair with the MitraClip system, followed by multivessel percutaneous coronary intervention (PCI) with drug-eluting stent implantation. Dual antiplatelet treatment was prescribed for 12 months after PCI
Le trappole della consulenza cardiologica in medicina interna: un ovvio caso di cirrosi epatica etilica [Pitfalls of cardiologic consultation in internal medicine: an obvious case of alcoholic liver cirrhosis]
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Metrics for Success of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension
No full textBalloon pulmonary angioplasty (BPA) has been developed as a compassionate procedure for symptomatic patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not candidates for pulmonary endarterectomy. With increasing physicians’ expertise, improvement of clinical results, and worldwide diffusion of the technique, definition of treatment goals has become crucial. The efficacy of BPA could be assessed from the patient’s perspective according to clinical endpoints as well as through the evaluation of surrogate endpoints that are known to hold significant prognostic value. The principal objective of BPA should be the stable relief of pulmonary hypertension (PH), with normalization of mean pulmonary artery pressure (<25 mmHg) and pulmonary vascular resistance (PVR). Importantly, clinical outcomes of BPA are the results of multiple-staged procedures, each one addressing several lesions in different lung territories. Hence, definition of metrics for success at a lesion level is a necessary step to guide the BPA procedures. To date, the best targets for BPA at the lesion level are normalization of pulmonary flow grade (PFG = 3) and abrogation of pressure gradient through the lesion (Pd/Pa < 0.8). Patients undergoing BPA represent a heterogeneous group and different target goals could be reasonably set for different patients. The effect of extensive anatomic revascularization beyond normalization of mPAP is under investigation and might be the target for selected patients. Standardization of definitions for efficacy and safety endpoints, in this context, seems necessary. This chapter describes endpoints and metrics for BPA that are commonly used in clinical practice and in the scientific literature
- …
