1,721,105 research outputs found
Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
No full textPurpose: Ternary amorphous solid dispersion (TASD) containing an additional component compared to conventional binary ASD further enhances the effectiveness of this strategy. Recently, polyphenolic compounds such as curcumin (CUR) and resveratrol (RES) are shown to have synergistic antioxidant, chemo-preventive, chondroprotective, and anticancer activity. However, their poor aqueous solubility limits their oral application. The purpose of this study is to design, characterized, and evaluate a soluble and stable TASD containing CUR and RES with a hydrophilic polymer.
Methods: Choosing an optimum polymer can be considered as one of the most crucial activities during TASD development. We carried out commonly used polymer screening studies i.e. miscibility, crystallization tendency, Flory-Huggins interaction parameter, solubility parameter, as well as advanced studies (i.e., crystallization kinetics and molecular interaction). Upon selection of the optimum polymer, TASDs were prepared by rotary evaporation. Pure drugs, their physical mixtures (PM), binary, and ternary ASDs were characterized by XRD, DSC, TGA, FTIR, and Raman spectroscopy. A 2-step in-vitro dissolution was carried out, under non-sink condition using a USP-II apparatus. Centrifuged samples were analyzed by a UV-Vis method. Finally, the long-term stability of TASDs was evaluated at room temperature.
Results: The screening studies focused on the miscibility, crystallization inhibition, and interaction capability of polymer. From three different polymers (i.e., EPO, HPMCAS, and S100), the miscibility study indicated the best miscibility of CUR and RES with EPO. From the crystallization kinetics study, we inferred that EPO has a better crystallization inhibition effect than HPMCAS and S100. Finally, interaction studies confirmed that all three polymers have the potential for hydrogen bonding. Besides, EPO showed acid-base interaction with both CUR and RES. Thus, EPO was selected to formulate a stable TASD with enhanced solubility and stability. A high drug-loaded (50% w/w) TASD was prepared and characterized to be in amorphous form with a single Tg. Strong interaction was confirmed with both FTIR and Raman spectroscopy. From the in-vitro dissolution study, it was observed that the % dissolved concentration Of CUR and RES from 50% drug-loaded TASD was respectively ~197 times and ~4 times higher than the PM after 1 hour. These TASD formulations were stable at room temperature for 12 months.ProQuest Traditional Publishing Optio
Story of the Story-Teller: A Conversation with Ramendra Kumar
Full text linkRamendra Kumar (Ramen) is an award-winning writer, storyteller and inspirational speaker with 42 books to his name. Ramen’s writings have been published by many of the leading publishers in the county and translated into 30 languages. They have found a place in several textbooks and anthologies. He has written across all genres ranging from picture books to adult fiction, satire, poetry, travelogues, biographies and on issues related to parenting and relationships. He has been invited to literary festivals held in Denmark, Greece, Sharjah, Sri Lanka as well Indian events including the prestigious Jaipur Litfest to conduct storytelling sessions and creative writing workshops. He has also been empanelled by Pearson India Education Services as well as several schools to conduct workshops. He was nominated as a Jury Member for the Best Children’s Author Category of The Times of India’s ‘Women AutHer’ Awards 2020. Many of his stories have been showcased by popular audio streaming, apps both within and outside the country, such as Spotify, Gaatha, Talking Stories Radio – London et al.
An Engineer & an MBA, Ramen was serving as the General Manager (Corporate Communications), SAIL, Rourkela Steel Plant, when he took Voluntary Retirement to pursue his passion, in August 2020. To know more about the writer, you can visit his website www.ramendra.in & his page on Wikipedia. Dr. Sagar Kumar Sharma interviews the author and unfolds the pages of his life.
 
What we should learn from pandemic publishing
No full textRepository accompanying the Nature Human Behavior comment article by Satyaki Sikdar, Sara Venturini, Marie-Laure Charpignon, Sagar Kumar, Francesco Rinaldi, Francesco Tudisco, Santo Fortunato, and Maimuna S. Majumder
What we should learn from pandemic publishing
No full textRepository accompanying the Nature Human Behavior comment article by Satyaki Sikdar, Sara Venturini, Marie-Laure Charpignon, Sagar Kumar, Francesco Rinaldi, Francesco Tudisco, Santo Fortunato, and Maimuna S. Majumder
What we should learn from pandemic publishing
No full textRepository accompanying the Nature Human Behavior comment article by Satyaki Sikdar, Sara Venturini, Marie-Laure Charpignon, Sagar Kumar, Francesco Rinaldi, Francesco Tudisco, Santo Fortunato, and Maimuna S. Majumder
The Race to COVID-19 Research
No full textRepository accompanying the Nature Human Behavior comment article by Satyaki Sikdar, Sara Venturini, Marie-Laure Charpignon, Sagar Kumar, Francesco Rinaldi, Francesco Tudisco, Santo Fortunato, and Maimuna S. Majumder
“An Unapologetic Utopian”: Vinita Agrawal in Conversation with Sagar Kumar Sharma
Full text linkIntervie
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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