105,922 research outputs found
Self-organising management of Grid environments
No full textThis paper presents basic concepts, architectural principles and algorithms for efficient resource and security management in cluster computing environments and the Grid. The work presented in this paper is funded by BTExacT and the EPSRC project SO-GRM (GR/S21939)
Endocarditis de Libman-Sacks
No full textResumenLa endocarditis de Libman-Sacks es una manifestación cardiaca bien reconocida del lupus eritematoso sistémico en la que se observan vegetaciones valvulares estériles, con predominio en el lado izquierdo del corazón, especialmente en la válvula mitral. La mayoría de los pacientes son asintomáticos; sin embargo, en la presentación clínica la forma aguda puede imitar a la de una endocarditis infecciosa (endocarditis pseudoinfecciosa) y complicar tanto el diagnóstico diferencial como el tratamiento.Se reporta el caso de un paciente de género masculino, de 63 años, quien manifestó signos y síntomas compatibles con endocarditis infecciosa, y cuyos diferentes estudios demostraron una endocarditis de Libman-Sacks que respondió de forma favorable al tratamiento inmunosupresor.AbstractThe Libman-Sacks endocarditis is a well-recognized systemic lupus erythematosus manifestation in which cardiac valvular sterile vegetations are observed predominantly in the left side of the heart, especially in the mitral valve. Most patients are asymptomatic; however, the acute clinical presentation may mimic an infectious endocarditis (pseudo-infectious endocarditis) and complicate both the differential diagnosis and treatment.The case of a 63 year-old male patient, who presented signs and symptoms consistent with infectious endocarditis and whose several studies demonstrated Libman-Sacks endocarditis and who responded favorably to immunosuppressive therapy, is reported
Re-presenting culture and the self: (Dis)agreeing in theory and in practice
No full textWe try to show that the fundamental grounds of psychological thinking about the domains of ‘culture’ and ‘the self’ (and their possible connections) are necessarily representationalist in the Cartesian sense. Rehearsing Heidegger’s critique of representationalism as the basic wrong turning taken by modern thinking generally (and by psychology in particular) with respect to what human being is, we move on to the possibility of a counter-representationalist re-specification of the concept of culture. Here we mobilize ideas from Husserl and Heidegger (again), and also from the basic ethnomethodological theory of Sacks and Garfinkel, to argue for the primacy of culture as an order of practical-actional affairs that makes conceptualizations of a putative ‘self’ always an effect of, and subsequent to, that very (cultural) order. Accordingly, we end by briefly analysing an actual case of an explicitly cultural use of a supposedly intensional term, ‘agree’
Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials
No full textAn important class of biomaterials is composed of layered networks of elastomeric fibers. While there is a growing interest in modeling and simulation of the mechanical response of these biomaterials, a theoretical foundation for such simulations has yet to be firmly established. The present work addresses this issue in two ways. First, using methods of geometric probability we develop theoretical estimates for the linear and areal fiber intersection densities for two-dimensional fibrous networks. These are expressed in terms of the fiber density and orientation distribution function, both of which are relatively easy to measure properties. Secondly, we develop a random walk algorithm for geometric simulation of two-dimensional fibrous networks which can accurately reproduce prescribed fiber density and orientation distribution function. Furthermore, the linear and areal fiber intersection densities obtained with the algorithm are in agreement with the theoretical estimates. Both theoretical and computational results are compared with those obtained by post-processing of SEM images of actual scaffolds. These comparisons reveal difficulties inherent to resolving fine details of multilayered fibrous networks. We also note that one should think not in terms of sufficiently large specimens for analysis, but rather sufficiently fiber-filled specimens. Correctly identifying and matching key geometric features is a critically important first step for performing reliable mechanical simulations. The methods provided herein can provide a rational means to define and generate key geometric features from scaffold structural data
Influence of storage conditions on the composition of red wines
No full textKnowledge of the influence of temperature on the chemical composition of red wines should be useful, given that inappropriate storage is likely to shorten shelf life while decreasing wine quality. Putative markers of ageing for red wines stored for two years at two different storage temperatures (cellar vs. domestic) were investigated using MS-based untargeted metabolomics, and further confirmed by additional metabolite profiling. Of the 10k features extracted from the metabolomic dataset, those significant in terms of their ability to distinguish between the two storage conditions were mostly pigments and other phenolics, several of which were annotated with 1st level identification. Tentative identification of the remaining chromatographic peaks was made by using spectral features, literature information about chromatographic properties and mass spectra records from databases and an internal database for the wine metabolome based on the bibliography. The results of multivariate analysis clearly showed that wines stored in the cellar changed little even after two years of storage, while wines stored in typical domestic conditions developed approximately 3-4 times faster. Ageing in domestic conditions appeared to induce an accelerated decrease in native anthocyanins, while specifically promoting the formation of pinotin A-like pigments. Interestingly, we observed a temperature-dependent pathway involving the addition of bisulfite to the flavanols and leading to the formation of several catechin and proanthocyanidin sulfonates, along with hydrolysis reactions involving various phenolics, including flavonols. The temperature-dependent sulfonation process of flavanols was reproduced in a model wine system, making it possible to isolate the main reaction products. Two main metabolites were structurally elucidated using NMR measurements and confirmed to correspond to the products found in wines aged in domestic conditions. Epicatechin 4β-sulfonate and procyanidin B2 4β-sulfonate are suggested as promising markers present in wines stored at elevated temperatur
Las vidas secretas de las cosas: una aproximaciónfenomenológica a la narrativa vital de Oliver Sacks
No full textFramed within the phenomenological turn that literary studies have experienced through the last few decades, this article analyses Oliver Sacks’ narrative of the life course in Uncle Tungsten(2001) and Gratitude(2015) as about the very act of embodied perception from an object-oriented perspective. Sacks presents himself as what French philosopher Maurice Merleau-Ponty depicted as a «phenomenal body», a sentient body playing an active and intentional role ‒ in the phenomenological sense of being directed toward something ‒ in his/her relation to and perception of the self, nature, and the other. This study reads Sacks’ narrative as an outstanding literary illustration of Gilbert G. Germain’s presentation of Merleau-Ponty’s phenomenology of perception as a return journey to a world permeated by an affective, lyrical, and enigmatic understanding of science where the embodied perception of natural objects is central to the recognition of the self and what surrounds it.Enmarcado en el giro fenomenológico que han experimentado los estudios literarios en las últimas décadas, este artículo analiza la narrativa vital de Oliver Sacks en Uncle Tungsten(2001) y Gratitude(2015) como textos que representan el acto de la percepción corporal desde el punto de vista de la relación del ser con los objetos. Sacks se muestra en estas obras autobiográficas como lo que Maurice Merleau-Ponty describió como el cuerpo fenomenológico, un cuerpo dotado de sentidos con una función activa e intencional –en el sentido fenomenológico de la acción orientada hacia algo–con respecto a la percepción de sí mismo, la naturaleza y el otro. Este artículo presenta la narrativa de Sacks como un brillante ejemplo literario de la concepción que Gilbert G. Germain tiene de la fenomenología de la percepción de Merleau-Ponty como elregreso a un mundo permeado por una visión afectiva, lírica y enigmática de la ciencia en la que lapercepción corporal de los objetos de la naturaleza es esencial para el reconocimiento de uno mismo y del entorno
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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