10 research outputs found
Weathering of Valle Ricca stiff and jointed clay
No full textThe study proposes a weathering model of Pliocene-Pleistocene stiff and jointed blue-grey clay transforming into yellow clay. Physical, mineralogical, chemical and textural changes, as well as the weathering profile were investigated in a quarry of central Italy. Based on geological records and inferences, these changes are likely to have occurred within a time-span of about 50,000 years BP, upon overburden stress unloading and in a stress regime that is locally controlled by suction. Weathering propagated into the clay at a rate of about 0.3 mm/year and was enhanced by the enlargement of the pre-existing tectonic discontinuities and by the fori-nation of new joints. A mass loss of about 22-25 wt.% was calculated. Considering Fe and P as immobile elements, the individual oxides contribute to mass loss in the following order: SiO2 > CaO = CO2 > Al2O3 > MgO > K2O > S > Na2O > TiO2 > MnO. The Fe2O3/(Fe2O3+FeO) ratio varies from 9-29% in the blue-grey clay to 75-82% in the yellow one. Oxidation and/or dissolution of 7 angstrom-Fe2+-bearing clay minerals, mica-like minerals and calcite and parallel increase of smectite and Fe-hydroxides play a critical role in the chemical changes and explain the higher plasticity of the yellow clay with respect to the blue-grey one. The role of water during the weathering process was inferred to occur in cyclical steps: 1) seepage of meteoric water; 2) dissemination of highly oxidizing meteoric water; 3) triggering of oxidation and dissolution of minerals; 4) water evaporation; 5) partial migration of the elements contained in the aqueous solution and consequent deposition of minerals in the joints. (C) 2005 Elsevier B.V. All rights reserved
On-line polylogues: conversation structure and participation framework in internet newsgroups
No full textInternational audienceThis paper deals with discussions within internet (usenet) newsgroups. These discussions can be described as computer-mediated or ‘on-line’ polylogues. We observe that the specific features of newsgroups (computer-mediated communication, asynchronicity, and the public nature of the messages) have many repercussions on conversation structure and on participation framework. A newsgroup is a set of multiple conversations in which exchanges of messages are often truncated. The conversational sequences are generally very short. Messages are sometimes inaccurately positioned in the sequential structure of the conversation. The conversation structure is sometimes misunderstood by the newsgroup users. Newsgroups also have a specific participation framework. There are three kinds of participant roles in a newsgroup: simple readers (or eavesdroppers), casual senders, and hosts. We can distinguish three levels in the production format: the transmitter (or animator) is the physical source of the message; the writer (or author) is the person who formulates the message; and the enunciator (or principal) is the participant to whose position the message attests. We can also distinguish several configurations of these production roles corresponding to several modes of participation (transmission, form, motive). Last, we can observe a three-party configuration of reception format: eavesdropper, favored recipient, and addressed recipient
Zmieniające się konwencje komunikacji internetowej
No full textIn the article, the author presents the results of the study of netiquette, that is, a multi-faceted collection of rules and conventions governing computer-mediated communication. The aim of the study was to establish whether these conventions have changed with the advent of new modes of online interaction. The research was based on the categories proposed by Michel Marcoccia (1998), against which some of the early formulations of netiquette and their modern versions were compared. Such comparison allowed the author to identify the areas of change as well as draw some conclusions regarding their origins and directions.W artykule autor przedstawia wyniki swojego badania, którego przedmiotem była netykieta, czyli niejednorodny zbiór zasad i konwencji przeznaczonych dla osób komunikujących się przez internet. Celem analizy było ustalenie, czy konwencje rządzące komunikacją internetową zmieniły się wraz z rozpowszechnieniem nowych form interakcji za pośrednictwem komputera. Opierając się na kategoriach zaproponowanych przez Michela Marcoccię (1998), autor porównuje zasady netykiety z lat dziewięćdziesiątych z ich współczesnymi odpowiednikami, identyfikując w ten sposób nowe konwencje rządzące światem wirtualnym
Remediating Conference Speeches: the Role of Authoriality in Live Twitter Entries
No full textThis paper focuses on new forms of rewriting and remediation that have been introduced within the context of new media and have now become extremely popular. Specifically, it investigates the practice of live-tweeting, i.e. engaging “on Twitter for a continuous period of time with a sequence of focused Tweets”(), which has become increasingly common thanks to the rapid spread of Internet and mobile phone-mediated communication. Significant public speaking events such as, for examples, political speeches, business presentations and conferences are now almost routinely live-tweeted about. In particular, the latter have been attracting more and more “live-tweeterers” as microblogging provides an excellent tool for the diffusion of content: this “enabled backchannel” (Ross et al. 2011) gives all Internet users the possibility of virtually attending academic talks and presentations. One of the reasons underlying the quick growth of conference live-tweeting has to do with the fact that it boosts interaction and allows users to attract public attention as well as gain new followers, which means that this practice can be turned into a tool of academic self-promotion (Ebner / Rheinahart 2009). For this to happen, however, conference tweeterers have to be able to post entries in which their own academic identity emerges and not solely the voice of the speaker whose presentation they are reporting about. As a matter of fact, live-tweeterers do not normally limit themselves to simply reproducing the presentation they are listening to so that it can be broken down into language “chunks” that can fit the tweet format (140 characters), but they also re-write the text of conference speeches and present it to a different, “networked” audience (Boyd et al. 2010). That is why it can therefore be affirmed that the original wording of presentations undergoes a process of reformulation and remediation. In live-tweets the voices of conference speakers and conference live-tweeterers are combined with the result that the concept of authoriality becomes very difficult to define.
As a matter of fact, differently from what happens in a conference presentation where speakers’ authoriality emerges in the speech clearly and unchallenged, in conference live-tweets it is oftentimes hard to establish the participation role of the tweeterer. This study aims at identifying the ways in which the identity and authoriality of conference speakers and live-tweeterers are blended together in tweets. In order to tackle this issue I collected a corpus of about 2,000 tweets posted in the course of eight Applied Linguistics Conferences held in 2012. The collected tweets were investigated with the help of the methodological tools provided by Goffman’s Frame Analysis. As suggested by many studies on Internet genres (cf., among others, Coupland N./Coupland J. 2000; Marcoccia 2004; Garzone 2007; Aarsand 2008) Goffmanian taxonomies can only be applied to Internet- and mobile phone-based communication to a certain degree, so this study also intends to verify whether new, ad hoc categories should replace older ones or if the latter can still be legitimately utilized, as long as they undergo a process of adaptation to the Internet environment.
The Goffmanian concepts of animator, author and principal are applied to conference live-tweets to examine how these roles are performed and what language resources can be associated with them. The second and final part of the study focuses instead on the discursive construction of the textual self of the conference live-tweeterer as well as on those devices that Goffman considers “the interesting and analytically relevant point” of the speaking event and that allow presenters to alter their alignment with the audience (i.e. non-literal meanings, text brackets and parenthetical remarks).
References
Aarsand, André P. 2008. Frame Switches and Identity Performances: Alternating between Online and Offline. Text & Talk. 28 (2), 147-165.
Boyd, Danah / Golder, Scott / Lotan, Gilad. 2010. Tweet Tweet Retweet: Conversational Aspects of Retweeting on Twitter. Proceedings of the 43th Annual Hawaii International Conference on System Sciences HICSS-43, IEEE: Kauai, HI. .
Ross, Claire/ Terras, Melissa / Warwick, Claire / Welsh, Anne 2011. Pointless Babble or Enabled Backchannel: Conference Use of Twitter by Digital Humanists. Journal of Documentation. 67(2), 214-237.
Coupland, Nicholas and Coupland, Justine (2000). Relational frames and pronominal address/ reference: The discourse of geriatric medical triads. In Sarangi, Srikant / Coulthard, Malcolm R. (eds.), Discourse and Social Life. Harlow, Essex: Pearson Education, 207–229.
Ebner, Martin / Rheinhart, Wolfgang 2009. Social networking in scientific conferences –Twitter as tool for strengthen a scientificcommunity. .
Garzone, Giuliana. 2007. Genres, Multimodality and the World Wide Web: Theoretical Issues .In Garzone/Poncini/Catenaccio (eds), 15-30.
Goffman, Erving. 1981. Forms Of Talk. Philadelphia: University of Pennsylvania Press.
Marcoccia, Michel 2004. On-line Polylogues: Conversation Structure and Participation Framework in Internet Newsgroups. Journal of Pragmatics. 36(2004), 115-145.
“Live Tweeting Best Practices”, Twitter, <https://dev.twitter.com/media/live-tweeting
Search for heavy diboson resonances in semileptonic final states in pp collisions at s=13 TeV with the ATLAS detector
No full textThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder
No full textBackground: Overlapping chronic multisymptom illnesses (CMI) include Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel syndrome, multiple chemical sensitivity, and Gulf War illness (GWI), and subsets of autism spectrum disorder (ASD). GWI entails a more circumscribed set of experiences that may provide insights of relevance to overlapping conditions.
Objectives: To consolidate evidence regarding a role for oxidative stress and mitochondrial dysfunction (OSMD), as primary mediators in CMI, using GWI as a departure point.
Methods: Exposure relations, character, timecourse and multiplicity of symptoms, and objective correlates of GWI are compared to expectation for OSMD. Objective correlates of OSMD in GWI and overlapping conditions are examined. 
Discussion: OSMD is an expected consequence of known GWI exposures; is compatible with symptom characteristics observed; and accords with objective markers and health conditions linked to GWI, extending to autoimmune disease and infection. Emergent triangulating evidence directly supports OSMD in multisymptom “overlap” CMI conditions, with similarities to, and diagnosed at elevated rates in, GWI, suggesting a common role in each. 
Conclusions: GWI is compatible with a paradigm by which uncompensated exposure to oxidative/nitrative stressors accompanies and triggers mitochondrial dysfunction, cell energy compromise, and multiple downstream effects such as vulnerability to autoantibodies. This promotes a profile of protean symptoms with variable latency emphasizing but not confined to energy-demanding post-mitotic tissues, according with (and accounting for) known properties of multisystem overlap conditions. This advances understanding of GWI; health conditions attending GWI at elevated rates; and overlap conditions like CFS and ASD, providing prospects for vulnerability assessment, mitigation of progression, treatment, and future prevention – with implications germane to additive and excessive environmental oxidative stressor exposures in the civilian setting.

Search for flavour-changing neutral-current interactions of a top quark and a gluon in collisions at TeV with the ATLAS detector
No full textA search is presented for the production of a single top quark via
left-handed flavour-changing neutral-current (FCNC) interactions of a top
quark, a gluon and an up or charm quark. Two production processes are
considered: and . The analysis is based on
proton-proton collision data taken at a centre-of-mass energy of 13TeV with
the ATLAS detector at the LHC. The data set corresponds to an integrated
luminosity of 139 fb. Events with exactly one electron or muon, exactly
one -tagged jet and missing transverse momentum are selected, resembling the
decay products of a singly produced top quark. Neural networks based on
kinematic variables differentiate between events from the two signal processes
and events from background processes. The measured data are consistent with the
background-only hypothesis, and limits are set on the production cross-sections
of the signal processes: pb and pb at the 95% confidence
level, with being the sum of
branching ratios of all three leptonic decay modes of the boson. Based on
the framework of an effective field theory, the cross-section limits are
translated into limits on the strengths of the and couplings
occurring in the theory: TeV and
TeV. These bounds correspond to
limits on the branching ratios of FCNC-induced top-quark decays:
and
.Comment: 51 pages in total, author list starting page 35, 7 figures, 4 tables,
published by Eur. Phys. J. C, All figures including auxiliary figures are
available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2018-06
Search for Dijet Resonances in Events with an Isolated Charged Lepton Using √s=13 TeV Proton-Proton Collision Data Collected by the ATLAS Detector
No full textMitsou, Vasiliki A./0000-0002-1533-8886; Portales, Louis/0000-0002-9860-9185; Gouveia, Emanuel/0000-0002-7785-2047; Leitgeb, Clara Elisabeth/0000-0002-0335-503X; Orlando, Nicola/0000-0003-0616-245X; Albert, Justin/0000-0003-0253-2505; Mlynarikova, Michaela/0000-0003-2028-1930; Nitta, Tatsumi/0000-0002-9234-4833; Asimakopoulou, Eleni Myrto/0000-0003-2127-373X; Elliot, Alison/0000-0003-0921-0314; Bhattacharya, Deb Sankar/0000-0003-3837-4166; Murray, William/0000-0003-1710-6306; Shaikh, Nabila Wahab/0000-0001-9358-3505; Duperrin, Arnaud/0000-0002-5789-9825; Dittus, Fridolin/0000-0002-1760-8237; Boutle, Sarah/0000-0002-8732-2963; Wang, Song-Ming/0000-0002-5821-4875; Perini, Laura/0000-0003-3715-0523; Haug, Sigve/0000-0003-0442-3361; Tal Hod, Noam/0000-0001-5241-0544; Anisenkov, Alexey/0000-0002-7201-5936; Hopkins, Walter/0000-0001-7814-8740; Leone, Sandra/0000-0001-6222-9642; Shulga, Evgeny/0000-0001-5099-7644; Ereditato, Antonio/0000-0002-5423-8079; Kendrick, James/0000-0001-9845-5473; Munoz Sanchez, Francisca/0000-0002-6374-458X; Palestini, Sandro/0000-0002-4110-096X; Schaefer, Leigh/0000-0003-1355-5032; Lyubushkin, Vladimir/0000-0003-0136-233X; Carquin, Edson/0000-0002-7863-1166; Shi, Liaoshan/0000-0001-9532-5075; Jakel, Gunnar/0000-0001-5687-1006; Chargeishvili, Bakar/0000-0002-5376-2397; Biesuz, Nicolo Vladi/0000-0003-3004-0946; Kukla, Romain/0000-0002-1140-2465; Affolder, Anthony/0000-0002-9058-7217; Yabsley, Bruce/0000-0002-2680-0474; Wolf, Anton/0000-0002-4368-9202; Schiavi, Carlo/0000-0003-0957-4994; Gonzalez De La Hoz, Santiago/0000-0001-5304-5390; Garcia Pascual, Juan Antonio/0000-0002-7399-7353; Romain, Madar/0000-0002-6875-6408; Dietrich, Janet/0000-0001-7061-1585; Cetin, Serkant Ali/0000-0001-5050-8441; Marcoccia, Lorenzo/0000-0001-6422-7018; Simoniello, Rosa/0000-0003-2042-6394; Franco, Fernando/0000-0002-0808-7791; Ellert, Mattias/0000-0001-5265-3175; Meoni, Evelin/0000-0002-6934-3752; Geanta, Andrei-Alexandru/0000-0003-2781-2933; Walkowiak, Wolfgang/0000-0002-0385-3784; Puri, Akshat/0000-0001-7843-1482; Davidek, Tomas/0000-0002-3770-8307; Astalos, Robert/0000-0001-5095-605X; Berger, Nicolas/0000-0002-7963-9725; Kar, Deepak/0000-0002-4238-9822; Raine, John/0000-0002-5987-4648; Marzin, Antoine/0000-0003-4364-4351; Roy, Avik/0000-0002-0116-1012; Penc, Ondrej/0000-0002-5433-3981; Li, Shu/0000-0001-7879-3272; Bitadze, Alexander/0000-0001-7979-1092; Zhu, Hongbo/0000-0001-8066-7048; Scornajenghi, Matteo/0000-0001-5967-8471; Gkougkousis, Evangelos - Leonidas/0000-0002-2132-2071; Beretta, Matteo Mario/0000-0002-7026-8171; Sykora, Ivan/0000-0003-3447-5621; Wolter, Marcin/0000-0001-9184-2921; Behr, J. Katharina/0000-0002-5501-4640; Padilla, Cristobal/0000-0001-7951-0166; Alimonti, Gianluca/0000-0002-7128-9046; Saimpert, Matthias/0000-0002-3765-1320; Cranmer, Kyle/0000-0002-5769-7094; D'Eramo, Louis/0000-0002-4910-5378; Biondi, Silvia/0000-0002-1492-6715; Charman, Thomas/0000-0001-6288-5236; Vukotic, Ilija/0000-0003-0472-3516; Grandi, Mario/0000-0002-5924-2544; Bannoura, Arwa/0000-0002-7166-8118; Castro, Nuno/0000-0001-8491-4376; Fabiani, Veronica/0000-0002-7635-7095; Cakir, Orhan/0000-0002-9016-138X; Bruno, Salvatore/0000-0001-5422-8228; Mezquita, Costa/0000-0002-2064-2954; Gregor, Ingrid Maria/0000-0002-5976-7818; David, Claire/0000-0002-1794-1443; Alpigiani, Cristiano/0000-0002-7641-5814; Terzo, Stefano/0000-0003-3388-3906; Kiryunin, Andrey/0000-0001-7490-6890; Starovoitov, Pavel/0000-0003-1990-0992; Vermeulen, Jos/0000-0003-4378-5736; Herten, Gregor/0000-0001-7661-5122; Truong, Thi Ngoc Loan/0000-0001-8249-7150; Nagasaka, Yasushi/0000-0002-3669-9525; Lloyd, Stephen/0000-0002-5073-2264; Grosse-Knetter, Jorn/0000-0003-3085-7067; Konig, Adriaan/0000-0001-6702-6473; Pollard, Christopher/0000-0002-3690-3960; Anastopoulos, Christos/0000-0003-1587-5830; Doglioni, Caterina/0000-0002-1509-0390; Lavorgna, Marco/0000-0002-3407-752X; Buttar, Craig/0000-0003-0188-6491; Solovyev, Victor/0000-0002-9402-6329; Pani, Priscilla/0000-0003-2149-3791; Ntekas, Konstantinos/0000-0001-9252-6509; Mildner, Hannes/0000-0002-0384-6955; Rompotis, Nikolaos/0000-0003-2577-1875; Bortoletto, Daniela/0000-0002-1287-4712; Staszewski, Rafal/0000-0001-7708-9259; Vetterli, Michel/0000-0002-7223-2965; Carli, Ina/0000-0002-0411-1141; Ravina, Baptiste/0000-0002-1622-6640; Shapiro, Marjorie/0000-0001-8540-9654; Vazquez Schroeder, Tamara/0000-0002-9780-099X; Gonella, Laura/0000-0002-4919-0808; Zanzi, Daniele/0000-0002-1222-7937; Canale, Vincenzo/0000-0003-2303-9306; Salzburger, Andreas/0000-0001-6004-3510; Pham, Thu Lh/0000-0002-8859-1313; Trigger, Isabel/0000-0002-6127-5847; Straessner, Arno/0000-0003-2460-6659; D'Auria, Saverio/0000-0003-3393-6318; Manhaes De Andrade Filho, Luciano/0000-0003-1792-6793; Reichert, Joseph/0000-0003-2110-8021; Ventura, Andrea/0000-0002-3368-3413; Schouwenberg, Jeroen/0000-0002-8738-9519; Vaidya, Amal/0000-0003-4086-9432; Mueller, James/0000-0001-5099-4718; Dell'Acqua, Andrea/0000-0003-2453-7745; Meirose, Bernhard/0000-0003-0032-7022; Flores, Lucas/0000-0002-2748-758X; Gaudio, Gabriella/0000-0002-6833-0933; Gonnella, Francesco/0000-0003-0885-1654; Sato, Koji/0000-0001-8988-4065; Gonzalez Sevilla, Sergio/0000-0003-4458-9403; Kersevan, Borut/0000-0002-4529-452X; Kouskoura, Vasiliki/0000-0002-8987-3208; Marti-Garcia, Salvador/0000-0002-3897-6223; Croft, Vincent Alexander/0000-0002-8731-4525; Komarek, Tomas/0000-0002-3047-3146; Feligioni, Lorenzo/0000-0002-1403-0951; Hirose, Shigeki/0000-0002-2389-1286; Massa, Lorenzo/0000-0002-3735-7762; Vasile, Matei-Eugen/0000-0001-8415-0759; Poulsen, Trine/0000-0001-7207-6029; Mankinen, Katja/0000-0001-7357-9648; Honda, Shunsuke/0000-0002-0403-3729; Du, Dongshuo/0000-0002-6758-0113; Ciesla, Krzysztof/0000-0003-2751-3474; Schmitt, Stefan/0000-0001-8387-1853; Strizenec, Pavol/0000-0003-0958-7656; Da Fonseca Pinto, Joao Victor/0000-0003-1746-1914; Maj, Klaudia/0000-0003-4819-9226; Ricken, Oliver/0000-0001-5107-7276; Stabile, Alberto/0000-0002-6868-8329; Lefebvre, Michel/0000-0002-5560-0586; Pater, Joleen/0000-0002-0598-5035; Kourlitis, Vangelis/0000-0001-6568-2047; Grieco, Chiara/0000-0002-3955-4399; Oreglia, Mark/0000-0001-6203-2209; Berta, Peter/0000-0003-0780-0345; Wiglesworth, Craig/0000-0001-6219-8946; Haas, Andrew/0000-0002-4832-0455; Castillo, Florencia Luciana/0000-0002-1172-1052; Holmes, Tova/0000-0002-3959-5174; Lipniacka, Anna/0000-0002-8759-8564; Ferrando, James/0000-0002-1007-7816; Krauss, Dominik/0000-0002-6419-7602; Bassalat, Ahmed/0000-0002-0129-1423; Hoya, Joaquin/0000-0002-7562-0234; Liu, Bingxuan/0000-0002-0721-8331; Su, Dong/0000-0001-6980-0215; Derendarz, Dominik/0000-0001-5660-3095; Dingfelder, Jochen/0000-0001-5767-2121; Ellinghaus, Frank/0000-0003-3596-5331; Bogavac, Danijela/0000-0003-2138-9062; Mancini, Giada/0000-0001-6158-2751; Madugoda Ralalage Don, Madhuranga Thilakasiri/0000-0002-6033-944X; Maleev, Victor/0000-0003-1028-8602; Pascuzzi, Vincent R./0000-0003-3167-8773; Haney, Bijan/0000-0001-9238-0888; Gavrilyuk, Alexander/0000-0003-3837-6567; Turra, Ruggero/0000-0001-8740-796X; Hubaut, Fabrice/0000-0002-0113-2465; Smolek, Karel/0000-0002-5996-7000; Vos, Marcel/0000-0001-8474-5357; Gorini, Edoardo/0000-0002-7688-2797; Snesarev, Andrei/0000-0002-9067-8362; Herde, Hannah/0000-0001-8926-6734; Cristinziani, Markus/0000-0003-3893-9171; Francescato, Simone/0000-0001-5315-9275; Betti, Alessandra/0000-0003-0839-9311; Fassi, Farida/0000-0002-6423-7213; Tudorache, Valentina/0000-0001-5384-3843; Ryzhov, Andrey/0000-0002-0623-7426; Camplani, Alessandra/0000-0002-6386-9788; Ferrere, Didier/0000-0002-5687-9240; Coccaro, Andrea/0000-0003-2368-4559; Ragusa, Francesco/0000-0002-4064-0489; Hamdaoui, Hassane/0000-0001-5709-2100; 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Gonski, Julia/0000-0003-2037-6315; Bianchi, Riccardo Maria/0000-0001-7345-7798; Benoit, Mathieu/0000-0002-8623-1699; Aielli, Giulio/0000-0002-0573-8114; Sawyer, Craig/0000-0002-2027-1428; Cerri, Alessandro/0000-0002-1904-6661; Zhao, Pingchuan/0000-0003-0054-8749; Koulouris, Aimilianos/0000-0003-1012-4675; Bouhova-Thacker, Evelina/0000-0002-5103-1558; Stanislaus, Beojan/0000-0001-9007-7658; Wu, Sau Lan/0000-0001-5866-1504; Marjanovic, Marija/0000-0002-4468-0154; Arguin, Jean-Francois/0000-0003-0229-3858; Tsybychev, Dmitri/0000-0001-8212-6894; Rossi, Elvira/0000-0001-9476-9854; Yacoob, Sahal/0000-0001-6977-3456; Chan, Jay/0000-0001-7069-0295; Makovec, Nikola/0000-0001-5124-904X; Romano, Marino/0000-0002-6609-7250; Pereira, Rui/0000-0003-1411-5354; Riu, Imma/0000-0002-3742-4582; Vachon, Brigitte/0000-0001-8703-6978; Barranco Navarro, Laura/0000-0002-3380-8167; Marchese, Luigi/0000-0001-6627-8716; Beringer, Juerg/0000-0002-9975-1781; Corrigan, Eric Edward/0000-0003-2485-0248; Sliwa, Krzysztof/0000-0002-1201-4771; 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Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study
No full textOBJECTIVES: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.
METHODS: SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.
RESULTS: The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].
CONCLUSION: Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality
Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study
No full textObjectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality
