5,284 research outputs found
On the sheaf-theoretic SL(2, C) Casson–Lin invariant
No full textWe prove that the (τ-weighted, sheaf-theoretic) SL(2, C) Casson–Lin invariant introduced by Manolescu and the first author is generically independent of the parameter τ and additive under connected sums of knots in integral homology 3-spheres. This addresses two questions asked by Manolescu and the first author. Our arguments involve a mix of topology and algebraic geometry, and rely crucially on the fact that the SL(2, C) Casson–Lin invariant admits an alternative interpretation via the theory of Behrend functions.</p
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulva development
No full textLate events in the cell-cell signalling pathway that controls the specification of vulva cell fates in C. elegans are characterized. The lin-31 gene acts downstream of the ras homolog let-60 and encodes a member of the HNF-3/fork head family of DNA-binding transcription factors. lin-31 regulates how vulval precursor cells choose their fate and in lin-31 mutants, these cells do not properly choose which fate to express and therefore adopt any of the 3 possible vulval cell fates in a deregulated manner..RE: 68 ref.; SC: CA; PE; 0TSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0890-9369&isbn=&volume=7&issue=6&spage=933&pages=933-947&date=1993&title=Genes%20and%20Development&atitle=lin-31%2c%20a%20Caenorhabditis%20elegans%20HNF-3%2ffork%20head%20transcription%20factor%20homolog%2c%20specifies%20three%20alternative%20cell%20fates%20in%20vulva%20development.&aulast=Miller&pid=%3Cauthor%3EMiller%2c%20L%20M%3bGallegos%2c%20M%20E%3bMorisseau%2c%20B%20A%3bKim%2c%20S%20K%3C%2Fauthor%3E%3CAN%3E19932337278%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
No full textGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
[[alternative]]Attachment Styles, Conflict-Coping Strategies and Marital Satisfaction in Married Couples
No full text[[abstract]]Attachment Styles, Conflict-Coping Strategies and Marital
Satisfaction in Married Couples
Chia-Ling Lin
Abstract
The purpose of this study was to examine the relationships among spouses' attachment styles, conflict-coping strategies, and marital satisfaction. The sample was composed of 299 married couples living in the northern parts of Taiwan and having primary school-age children. Instruments used in this study were ”Experiences in Close Relationship Inventory”, “The Marital Coping Inventory”, and “Marital Satisfaction Inventory”. Data obtained were analyzed by contingency coefficient, One-way MANOVA, ANOVA and Canonical correlation. The major findings were as follows:
1. The relationship between spouse’s attachment styles
The result of contingency coefficient analysis revealed that husbands’ attachment style was significantly associated with wives’ attachment style. Secure participants tended to pair with secure partners and vice versa . The same was applicable to the preoccupied, fearful, as well as dismissing attachments. Among all types of pairing, the pairs of secure husbands and secure wives were most common, claiming a leading percentage of 17.4%.
2. Differences between husbands and wives regarding their
conflict-coping strategy and marital satisfaction
Data analysis indicated significant sex differences for conflict-coping strategy. The differences were evident in forms of conflict, introspective self-blame, positive approach, self-interest and seeking social support. Simply put, husbands reported greater use of positive approach and self-interest than did wives. Moreover, wives reported greater use of conflict, introspective self-blame, and seeking social support than did husbands.
As for marital satisfaction, husbands tended to be more satisfied than their wives for psychological aspects of marriage.
3. Difference among attachment styles regarding the conflict-
coping strategies and marital satisfaction
Results of the one-way MANOVA revealed that husbands and wives with different attachment styles were significantly different on conflict-coping strategies. Major differences lied in conflict, introspective self-blame, positive approach and avoidance. And there were differences on self-interest and seeking social support by husband with different attachment styles.
Results of the one-way MANOVA revealed that husbands and wives with different attachment styles were significantly different on marital satisfaction. Primary variations were of physical, economic, psychological, social, and philosophical aspects of marriage.
4. Differences among attachment styles pairing couples on the
conflict-coping strategies and marital satisfaction
Results of the one-way MANOVA revealed that husbands and wives paired with different attachment styles were significantly different on conflict-coping strategies. Major differences range from conflict, introspective self-blame, positive approach and avoidance.
Results of the one-way MANOVA revealed that husbands and wives paired with different attachment styles were significantly different on marital satisfaction. Primary variations were of physical, economic, psychological, social, and philosophical aspects of marriage.
5. The Relationships between conflict-coping strategy and
marital satisfaction
There are three canonical roots for husbands:
a. Husbands using more conflict, introspective self-blame and
avoidance, less positive approach, enjoy less satisfaction
in their physical, economic, social, psychological, and
philosophical aspects of marriage.
b. Husbands using more conflict, introspective self-blame,
positive approach, and seeking social support enjoy less
satisfaction in their social aspects of marriage.
c. Husbands involving themselves more in conflicts and social
supports and less in avoidance tend to get less physical satisfaction with their spouses.
There are two canonical roots for wives:
a. Wives using more conflict, introspective self-blame and
avoidance, less positive approach, enjoy less satisfaction
in their physical, economic, social, psychological,and
philosophical aspects of marriage.
b. Wives using methods like conflict, introspective self-blame,
and positive approach enjoy less satisfaction in both
economic and social aspects of the marriages.
Lastly, based on the above results, relevant implications were discussed and suggestions for the counseling services as well as future research were presented.
sj-docx-1-jic-10.1177_08850666221102815 - Supplemental material for Measuring Social Health Following Pediatric Critical Illness: A Scoping Review and Conceptual Framework
No full textSupplemental material, sj-docx-1-jic-10.1177_08850666221102815 for Measuring Social Health Following Pediatric Critical Illness: A Scoping Review and Conceptual Framework by Hannah Daughtrey, Katherine N. Slain, Sabrina Derrington, Idris V. R. Evans, Denise M. Goodman, LeeAnn M. Christie, Simon Li, John C. Lin, Debbie A. Long, Maureen A. Madden, Sara VandenBranden, McKenna Smith, Neethi P. Pinto, Aline B. Maddux, Ericka L. Fink, R. Scott Watson, Leslie A. Dervan and in Journal of Intensive Care Medicine</p
Obtaining Thickness-Limited Electrospray Deposition for 3D coating
No full textThe electrospray process utilizes the balance of electrostatic forces and surface tension within a charged spray to produce charged microdroplets with a narrow dispersion in size. In electrospray deposition, each droplet carries a small quantity of suspended material to a target substrate. Past electrospray deposition results fall into two major categories: (1) continuous spray of films onto conducting substrates and (2) spray of isolated droplets onto insulating substrates. A cross-over regime, or a self-limited spray, has only been limitedly observed in the spray of insulating materials onto conductive substrates. In such sprays, a limiting thickness emerges where the accumulation of charge repels further spray. In this study, we examined the parametric spray of several glassy polymers to both categorize past electrospray deposition results and uncover the critical parameters for thickness-limited sprays. The key parameters for determining the limiting thickness were (1) field strength and (2) the spray temperature, related to (1) the necessary repulsive field and (2) the ability for the deposited materials to swell in the carrier solvent vapor and redistribute charge. These control mechanisms can be applied to the uniform or controllably varied microscale coating of complex 3D objects.Peer reviewe
Uniqueness results for mean field equations with singular data
No full textWe prove uniqueness of solutions for mean field equations (Caglioti et. Al. Comm. Math. Phys. 174 (1995)) with singular data (Bartolucci et Al. Comm. Math. Phys. 229 (2002)),
arising in the analysis of two-dimensional turbulent Euler flows.
In this way, we generalize to the singular case some uniqueness results obtained by
Chang, Chen and the second author (Chang et. Al. New Stud. Adv. Math. 2 (2003)). In particular,
by using a sharp form of an improved
Alexandrov-Bol's type isoperimetric inequality, we are able to exploit the role played by
the singularities and then obtain uniqueness under weaker boundary regularity assumptions than those
assumed in (Chang et. Al. New Stud. Adv. Math. 2 (2003))
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
"Third Generation"-Type Functional Tris(2-pyridyl)borate Ligands and their Transition-Metal Complexes
No full textPhenyltris(2-pyridyl)borates (Tpyb) are a promising class of tripodal “scorpionate”-type ligands with potential utility in the development of transition metal complexes with interesting optical, electronic or magnetic properties, and as building blocks to metallosupramolecular polymers. We report here a new class of “third generation”-type Tpyb ligands that contain different functional groups attached to the boron-bound aryl moiety. The synthesis, characterization and metal ion complexation behavior of ligands with iodo and trimethylsilyl groups is discussed. The electrochemical and absorption characteristics of the corresponding low-spin Fe(II) and Ru(II) complexes are compared. We demonstrate the further elaboration of the iodo derivatives with alkynes via Sonogashira-Hagihara coupling, a process that proceeds with high yield for the Fe(II) and Ru(II) complexes, but not for the free ligand. The borylation of the silyl-substituted Ru(II) complex with BBr3 was also investigated. In addition to the expected borylation product, Ru(Tpyb-Bpin)2, the replacement of one (major product) or two phenyl groups is observed, suggesting that electrophilic borylation occurs at both the C(Ph)-Si and the C(Ph)-B aromatic carbons. The successful attachment of a range of different functional groups at the periphery of the Tpyb metal complexes is expected to provide opportunities to access new polymeric materials via C-C coupling or click-type reactions.Peer reviewe
C. elegans class A synMuv genes inhibit ectopic RAS-mediated vulval development by tightly restricting expression of lin-3 EGF
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (p. 236-259).The class A and B synthetic multivulva (synMuv) genes of C. elegans redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. The class B synMuv genes encode many proteins known to remodel chromatin and repress transcription. The class A synMuv genes likely also function in transcription, although their specific molecular functions are unknown. We have identified a class A synMuv mutation in the promoter of lin-3 EGF, revealing that lin-3 is the key biological target of the class A synMuv genes in vulval development. Using FISH with single mRNA molecule resolution, we found that class AB synMuv double mutants exhibit widespread ectopic lin-3 expression. Our results show that lin-3 EGF is normally expressed in the germline, and many class B synMuv genes have previously been implicated in inhibiting germline fates in somatic cells. We propose that the class A synMuv genes specifically repress ectopic lin-3 EGF expression through a site in the lin-3 promoter and the class B synMuv genes either directly or indirectly repress lin-3 as a consequence of their role in regulating the germline/soma distinction. The class A and B synMuv genes had previously been thought of as two parallel pathways, but we have found that each of those pathways is actually composed of multiple parallel pathways. While class AB synMuv double mutants have a strong Muv phenotype, most class AA synMuv double mutants exhibit a weak Muv phenotype, and most pairs of class B synMuv mutants can enhance each other in sensitized backgrounds, indicating that most genes within a class can function in parallel. We also found that some pairs of synMuv genes cannot act in parallel, indicating that they function together to repress ectopic lin-3 expression. We also report the molecular characterization of the class A synMuv gene lin-38 and the identification of mcd-1 as a class A synMuv gene. lin-38 and mcd-1 encode paralogous zinc-finger proteins. Unlike previously studied class A synMuv genes that function specifically in vulval development by repressing lin-3, both lin-38 and mcd-1 control multiple aspects of development by regulating target genes other than lin-3.by Adam M. Saffer.Ph.D
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