149 research outputs found
Wandel gestalten : Beiträge der Managementforschung zu Herausforderungen der Unternehmensführung
No full textSabine Bergner, Jürgen Fleiß, Alfred Gutschelhofer (Hg.) ; unter der Mitarbeit von Julia PlakolmEnthält: Literaturangaben(VLID)522275
Fostering entrepreneurship in an international university collaboration
No full text[EN] The European Union is taking action on enhancing entrepreneurship in Europe and recommends appropriate entrepreneurship training in schools and higher education institutions. Due to the globalization of businesses it seems to be appropriate to realize an international perspective on entrepreneurial issues and to develop international programmes for young entrepreneurs. In this case study, we examined an international university collaboration between two universities, one in Austria and one in the United States. The programme’s goals include the establishment of an international network for students and an awareness of the students of different cultural dimensions and entrepreneurial mindsets. Our findings show how this programme enables the students to work on their professional and behavioural skills, how these students work practice-oriented under the guidelines of experts from different entrepreneurial mindsets and how they become aware of cultural differences. Besides other aspects, it seems to be advantageous for international entrepreneurship programmes to remain open and flexible during the whole process and to offer a programme that allows students to integrate participation into their regular studies. Furthermore, it seems beneficial that students can tailor the programme to meet their specific needs.Rybnicek, R.; Gutschelhofer, A.; Bergner, S.; Seidenberger, A.; Taferner, R. (2017). Fostering entrepreneurship in an international university collaboration. En Proceedings of the 3rd International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 991-998. https://doi.org/10.4995/HEAD17.2017.5492OCS99199
Mental rotation of 2- and 3-dimensional objects: Sex differences, effects of training and changes in cortical activity
No full textMicroglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy
No full textX‐linked adrenoleukodystrophy (X‐ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction of peroxisomal or lysosomal lipid degradation. In both conditions, accumulation of nondegraded lipids leads to the destruction of cerebral white matter. Because of their high lipid content, oligodendrocytes are considered key to the pathophysiology of these leukodystrophies. However, the response to allogeneic stem cell transplantation points to the relevance of cells related to the hematopoietic lineage. In the present study, we aimed to better characterize the pathogenetic role of microglia in the above‐mentioned diseases. Applying recently established microglia markers to human autopsy cases of X‐ALD and MLD we were able to delineate distinct lesion stages in evolving demyelinating lesions. The immune‐phenotype of microglia was altered already early in lesion evolution, and microglia loss preceded full‐blown myelin degeneration both in X‐ALD and MLD. DNA fragmentation indicating phagocyte death was observed in areas showing microglia loss. The morphology and dynamics of phagocyte decay differed between the diseases and between lesion stages, hinting at distinct pathways of programmed cell death. In summary, the present study shows an early and severe damage to microglia in the pathogenesis of X‐ALD and MLD. This hints at a central pathophysiologic role of these cells in the diseases and provides evidence for an ongoing transfer of toxic substrates primarily enriched in myelinating cells to microglia
Lower MR-indexed locus coeruleus integrity in autosomal-dominant Alzheimer’s disease is related to cortical tau burden and memory deficits
No full textAuthors:
Martin J. Dahl* 1,2, Mara Mather 2, Markus Werkle-Bergner 1, Briana L. Kennedy 2,3, Samuel Guzman 4, Kyle Hurth4, Carol A. Miller 4, Yuchuan Qiao 5, Yonggang Shi5, Helena C. Chui 6, & John M. Ringman 6
Affiliations:
1 Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
2 Davis School of Gerontology, University of Southern California, 90089 Los Angeles, CA, USA
3 School of Psychological Science, University of Western Australia, Perth, Australia
4 Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
5 Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
6 Department of Neurology, Keck School of Medicine, University of Southern California, 90033 Los Angeles, CA, USA
* Corresponding author:
MJD (dahl [at] mpib-berlin.mpg.de)
We aimed at improving the reliability and validity of MR-based locus coeruleus detection. Leveraging a meta-analytical approach, we aggregated across previously published maps of the locus coeruleus (Betts et al., 2017; Dahl et al., 2019; Keren et al., 2009; Liu et al., 2019; Tona et al., 2017; Ye et al., 2020) to derive a biologically plausible volume of interest (meta mask) that shows high agreement across investigations. We freely share the locus coeruleus meta mask with the scientific community.
For a description of the methods, please see:
https://doi.org/10.1101/2020.11.16.2023256
Sex and training differences in mental rotation: a behavioral and neurophysiological comparison of gifted achievers, gifted underachievers and average intelligent achievers
No full text
- …
