14 research outputs found
Het totaal overziende
No full textOverzicht van waterbouwkundige innovaties, uitgegeven naar aanleiding van het emiritaat van prof. J.F. Agema. 1. Vrijling, J.K., Het totaal overziende; 2. Verkerk, H., Afsluiting Zuiderzee; 3. Agema, J.F., Dijkherstel oostelijk Zuid-Beveland; 4. Estourgie, A.L.P., Aanleg nieuwe havenmond Hoek van Holland; 5. Verbeek, G., Bijzonder materieel bij de uitvoering van de stormvloedkering in de Oosterschelde; 6. Struik, P., Optimalisatie van het ontwerp van de compartimenteringswerken in de Oosterschelde; 7. Altink, H., Alternatieven en keuze koelwatersysteem, Madras, IndiaHydraulic EngineeringCivil Engineering and Geoscience
The truth of personal names
No full textPortuguese-speakers, when asked about their personal names, often respond with a notion of the
‘truth of’ their names. Basing itself on ethnographic data collected by the author in Macao (southern
China), Bahia (Brazil), and Portugal, the article interprets this notion of truth as a form of ontological
weighing that postulates the unitariness of the person by reference to a subjection to a bureaucratic
order and to a cultural and linguistic universe associated to it
European Waste Statistics data for a Circular Economy Monitor: Opportunities and limitations from the Amsterdam Metropolitan Region
No full textAs appointed in the EU Circular Economy Action Plan, cities and regions in EU member countries start accompanying their circular economy strategies by monitoring frameworks, often called Circular Economy Monitors (CEM). Having the task to assess the performance towards the achievement of set targets and to steer decision-making, CEMs need to rely on a multitude of statistics and datasets. Waste statistics play an important role in circular economy monitoring as they provide insights into the remaining linear part of the economy. The collection of waste statistics is mandated by the European Commission which provides general guidelines on data collection and processing. The Netherlands has one of the most detailed waste registries among the EU countries. The country's largest metropolitan region, Amsterdam, is currently building a CEM which tracks progress over time towards the set goals, highlights which areas need improvement and estimates target feasibility. This paper uses the Amsterdam CEM as a case-study to explore how the existing system of waste registration in the Netherlands is able to support decision-making. The data is explored with the help of four queries that relate to the CEM's goals and require data mapping to be answered. The data mapping and analysis process has revealed several limitations present in the waste data collection and a number of gaps present in current circular economy research and data analysis. At the same time, the available data already supports significant insights into the status quo of the current waste system and provides opportunities for circular economy monitoring.Environmental Technology and Desig
The labour movement in Newcastle during the Great War, 1914-1918
No full textThis thesis is an attempt to tell the story of the labour movement in Newcastle during the First World War. The period was chosen because of its interest and because it was remote enough in time to be unclouded by contemporary prejudices. The author was provoked into considering the topic by Professor James Hagan of Wollongong University, who was writing a history of the New South Wales Labor Party. He complained that there was nothing written on the A.L.P. in Newcastle although it was the largest non-capital city in Australia, except J.C. Docherty's Honours Thesis on the Newcastle Conscription debates. The challenge was interesting, due to a long-standing involvement in Labor Party politics in Newcastle, and a curiosity whether the local perspective has been accurately reflected in the history written from the state and federal levels
The contribution of data mining to information science
No full textThe information explosion is a serious challenge for current information institutions. On the other hand, data mining, which is the search for valuable information in large volumes of data, is one of the solutions to face this challenge. In the past several years, data mining has made a significant contribution to the field of information science. This paper examines the impact of data mining by reviewing existing applications, including personalized environments, electronic commerce, and search engines. For these three types of application, how data mining can enhance their functions is discussed. The reader of this paper is expected to get an overview of the state of the art research associated with these applications. Furthermore, we identify the limitations of current work and raise several directions for future research
Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: A position statement of the ESC working group on myocardial and pericardial diseases
No full textIn this paper the Working Group on Myocardial and Pericardial Disease proposes a revised definition of dilated cardiomyopathy (DCM) in an attempt to bridge the gap between our recent understanding of the disease spectrum and its clinical presentation in relatives, which is key for early diagnosis and the institution of potential preventative measures. We also provide practical hints to identify subsets of the DCM syndrome where aetiology directed management has great clinical relevance. © The Author 2016
SARS-COV-2 viral RNA detection through oligonucleotide-capped nanoporous anodic alumina supports.
No full text[EN] We describe herein a sensor containing nanoporous anodic alumina (NAA) as sensing platform to identify SARSCOV-2 RNA using a gating mechanism. The system is based on NAA that contains a fluorescent dye (Rhodamine B; RhB) and is capped with an oligonucleotide sequence that hybridize specifically a region of SARS-CoV-2 genome. In the presence of RNA from SARS-COV-2 virus, the oligonucleotide of the surface is displaced, uncapping the pores, and producing a delivery of RhB. The detection of the virus is achieved measuring the fluorescence of the fluorophore. The nanosensor demonstrates to be highly sensitive and selective in aqueous buffers and in biological media, having a limit of detection (LOD) of 50 ± 30 copies mL-1 of SARS-CoV-2 RNA extracted from patients. Moreover, preliminary results using 18 real nasopharyngeal swab samples indicate the potential of the system to differentiate between infected and non-infected patients. Compared to the conventional RT-PCR method, in our system there is no need for sample pretreatment or RNA isolation, providing diagnostic outcomes within 60 mins while maintaining a high level of reliabilityThis study was sponsored by the Spanish Government (projects
PID2021-126304OB-C41 (DOROTHY), PID2021-128141OB-C22
(ANTIVIBEM), and PID2021-122875OB-100 (MCUI/AEI/ FEDER,
UE)), the Generalitat Valenciana (project no.2 RD 180/2020, CIPROM/
2021/007), Supera COVID-19 Fund (DIACOVID project), the Universitat
Polit`ecnica de Val`encia− Instituto de Investigacion ¿ Sanitaria La Fe (IISLaFe) (SARS-COV-2-SEEKER and VISION-COV projects). This research
project has received funding from the European Union s HORIZON-CL4-
2022 research and innovation programme under grant agreement ID
101093042, PHOTONGATE project. Funded by the European Union.
Views and opinions expressed are however those of the author(s) only
and do not necessarily reflect those of the European Union or European
Research Council. Neither the European Union nor th e granting authority can be held responsible for them. This work was supported by the
European Research Council (ERC) via Advanced Grant (101052997, EDISON). Also, the project has received funding from the European
Union s HORIZON-CL4-2022 research and innovation programme
under grant agreement ID 101093042, PHOTONGATE project. A.L.P.
thanks the Ministerio de Universidades for his predoctoral grant
(FPU20/05297). E. C. thanks the Instituto de Salud Carlos III (Miguel
Servet 2023 CP23/00086). Scheme 1 was done with BioRender.com.
The Medicaments Research Ethics Committee, CEIm of University and
Polytechnic La Fe Hospital of Valencia (2021-012-1) approved the use of
samples from human patients.López-Palacios, Alba;Aranda-Sobrino, MN.;Caballos-Gómez, María Isabel;Hernández-Montoto, Andy;Calbuig, E.;Gómez-Ruiz, MD.;Tormo-Mas, M.... (2025). SARS-COV-2 viral RNA detection through oligonucleotide-capped nanoporous anodic alumina supports. Sensors and Actuators Reports. 9. https://doi.org/10.1016/j.snr.2025.100298S
Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition
No full textIntroduction: Primary heart involvement in systemic sclerosis may cause morpho-functional and electrical cardiac abnormalities and is a common cause of death. The absence of a clear definition of primary heart involvement in systemic sclerosis limits our understanding and ability to focus on clinical research. We aimed to create an expert consensus definition for primary heart involvement in systemic sclerosis. Methods: A systematic literature review of cardiac involvement and manifestations in systemic sclerosis was conducted to inform an international and multi-disciplinary task force. In addition, the nominal group technique was used to derive a definition that was then subject to voting. A total of 16 clinical cases were evaluated to test face validity, feasibility, reliability and criterion validity of the newly created definition. Results: In total, 171 publications met eligibility criteria. Using the nominal group technique, experts added their opinion, provided statements to consider and ranked them to create the consensus definition, which received 100% agreement on face validity. A median 60(5–300) seconds was taken for the feasibility on a single case. Inter-rater agreement was moderate (mKappa (95% CI) = 0.56 (0.46–1.00) for the first round and 0.55 (0.44–1.00) for the second round) and intra-rater agreement was good (mKappa (95% CI) = 0.77 (0.47–1.00)). Criterion validity showed a 78 (73–84)% correctness versus gold standard. Conclusion: A preliminary primary heart involvement in systemic sclerosis consensus-based definition was created and partially validated, for use in future clinical research. © The Author(s) 2021
Consensus on the assessment of systemic sclerosis–associated primary heart involvement: World Scleroderma Foundation/Heart Failure Association guidance on screening, diagnosis, and follow-up assessment
No full textIntroduction: Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients. Methods: A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were categorized into relevant domains (conventional radiology, electrocardiography, echocardiography, cardiac magnetic resonance imaging, laboratory, and others) and presented to experts and one patient research partner, who discussed the data and added their opinion. This led to the formulation of overarching principles and guidance statements, then reviewed and voted on for agreement. Consensus was attained when the mean agreement was ⩾7/10 and of ⩾70% of voters. Results: Among 2650 publications, 168 met eligibility criteria; the data extracted were discussed over three meetings. Seven overarching principles and 10 guidance points were created, revised and voted on. The consensus highlighted the importance of patient counseling, differential diagnosis and multidisciplinary team management, as well as defining screening and diagnostic approaches. The initial core evaluation should integrate history, physical examination, rest electrocardiography, trans-thoracic echocardiography and standard serum cardiac biomarkers. Further investigations should be individually tailored and decided through a multidisciplinary management. The overall mean agreement was 9.1/10, with mean 93% of experts voting above 7/10. Conclusion: This consensus-based guidance on screening, diagnosis and follow-up of systemic sclerosis primary heart involvement provides a foundation for standard of care and future feasibility studies that are ongoing to support its application in clinical practice. © The Author(s) 2023
The role of biological rhythms and blood glucose levels in maintaining a positive mood state.
No full textA thesis submitted in partial fulfilment of the requirements of the University of
Wolverhampton for the degree of Doctor of PhilosophyAlthough the effects of both the menstrual and circadian cycles on mood have been well documented, the question of whether the two interact to influence mood has not yet been addressed, despite evidence for such an interaction on other variables. Blood sugar level is a major contributor to the mediation of mood and is easily regulated by dietary intervention; there is also evidence that it is influenced by both the menstrual and circadian cycles. The present research takes a positive psychological approach to managing mood; the aims were to identify where natural variations in mood occur in relation to its underlying physiology, taking an applied approach to suggest ways of effectively managing positive mood and maintaining psychological well-being. A series of studies was carried out to measure fluctuations in mood in relation to biological rhythms, and in response to cognitively demanding situations and simple interventions. Mood was measured throughout the research using the UWIST Mood Adjective Checklist. The most consistent results were in relation to the Energetic Arousal dimension. This was shown to be influenced by both the menstrual cycle and the time of day, as well as an interaction between these two factors, and was consistently related to changes in blood glucose levels. Energetic Arousal also appeared to be more sensitive to the effectsof the suggested interventions. Diurnal changes in mood throughout the course of a normal day were more evident among women in their premenstrual to menstrual phases, and also become more apparent in response to cognitive tasks. Trait Anxiety was a mediating factor in how individuals reacted to such tasks. Mood was closely related to blood glucose levels, and raising blood glucose to a robust but safe level effectivelyenhanced positive mood in cognitively demanding situations. Oral contraceptives generally tended to eliminate menstrual cycle-related effects on mood and responses to intervention. It was concluded that mood states among healthy women are influenced by a complex interplay between biological rhythms, physiological states, individual differences and the context in which these moods take place. Simple interventions that can easily be incorporated into one’s daily routine may be efficacious in maintaining a positive mood state, which has beneficial implications for psychological well-being
