189,740 research outputs found
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Two types of electronic states in one-dimensional crystals of finite length
No full textExact and general results on the electronic states in one-dimensional crystals bounded at tau and tau + L, where L = Na, N is a positive integer, and a is the potential period, are presented. Corresponding to each energy band of the Bloch wave, there are N - 1 states in the finite crystal whose energies are dependent on L but not on tau and map the energy band exactly. There is always one and only one electronic state corresponding to each band gap of the Bloch wave, whose energy is dependent on r but not on L. This state is either a constant-energy confined band-edge state or a surface state in the band gap. (C) 2002 Elsevier Science (USA).Physics, MultidisciplinarySCI(E)0ARTICLE122-3030
Bioleaching of marmatite flotation concentrate with a moderately thermoacidophilic iron-oxidizing bacterial strain
No full textBioleaching of a marmatite flotation concentrate with a moderately thermoacidophilic iron-oxidizing bacterial strain (MLY) was investigated in batch experiments. Experimental results showed that the dissolution rate of marmatite was influenced markedly by pH, temperature, pulp density and particle size of ore. The bioleaching of the concentrate by the moderate thermophile was more effective when carried out under the higher acidity and temperature compared with Acidithiobacillus ferrooxidans. The adapted strain of the moderate thermophile could provide more rapid and complete oxidation of marmatite than its original strain and in the sterile control. (c) 2005 Elsevier Ltd. All rights reserved
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A novel soluble brain-specific protein (Sy-1):identification and partial characterization
No full textA novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in rat brain and, in a partially identical form, in mouse brain. In rat brain the antigen is more concentrated in the brainstem than in the forebrain and cerebellum. On the basis of immunological, physico-chemical and biological criteria Sy-1 differs from other, already described, brain-specific proteins
Les Upanisad sont-elles une interprétation de données mystiques ? A propos de l'hypothèse de M. R. C. Zaehner dans « At Sundry Times »
No full textHoàng-sy-Quy Hoàng-Son. Les Upanisad sont-elles une interprétation de données mystiques ? A propos de l'hypothèse de M. R. C. Zaehner dans « At Sundry Times ». In: Revue de l'histoire des religions, tome 174, n°1, 1968. pp. 27-37
Food Value of the Rotifer, Brachionus plicatilis, Enriched with Synechocystis sp. SY-4, for the Larvae of Flounder, Paralichthys olivaceus
No full textP(論文)藍藻Synechocystis sp. SY-4で栄養強化したシオミズツボワムシのヒラメ仔魚に対する餌料価値を検討した。試験区は,SY-4で培養を行ったワムシ給餌区(S-R),SY-4とドコサ・ユーグレナで併用培養を行ったワムシ給餌区(SE-R),SY-4とナンノクロロプシスで併用培養を行ったワムシ給餌区(SN-R),ドコサ・ユーグレナで培養を行ったワムシ給餌区(E-R)およびナンノクロロプシスで培養を行ったワムシ給餌区(N-R)の5区を設けた。その結果,SY-4とドコサ・ユーグレナで併用培養を行ったワムシを給餌したSE-R区で,最も大きい成長がみられ,生残率も94.9%(日齢30)と高くなることが認められた。また,SY-4とナンノクロロプシスで併用培養を行ったワムシを給餌したSN-R区においても大きな成長がみられ,生残率も94.4%(日齢30)と高くなることが認められた。Larva rearing of the flounder, Paralichthys olivaceus, was conducted in order to evaluate the food value of the rotifer, Brachionus Nicatilis, enriched with a blue-green alga, Synechocystis sp. SY-4. The dietary value of rotifers enriched with SY-4 (S-R), SY-4 and Euglena gracilis enriched with DHA (SE-R) or SY-4 and Nannochtorolsis ocutata (SN-R) was compared with that of rotifers enriched with Euglena gracilis (E-R) or Nannochloropsis oculata (N-R) by feeding these rotifers to larval flounder for 25 days. The rotifers enriched with these microalgae after culture with Tetraselmis tetrathele was given to the larvae. The growth of larvae fed SE-R was better than others (SE-R 10.8 mm.vs. S-R 9.2 mm, SN-R 10.0 mm, E-R 8.5 mm and N-R 9.8 mm in average T.L.), although the survival rate of the larvae fed E-R was better than others (E-R 94.9 % vs. S-R 88.8 %, SE-R 92.0 %, SN-R 94.4 % and.N-R 94.7 %). Perhaps the content of ω3 HUFA in S-R was not enough for larval flounder. However, the dietary value was effectively improved due to incorporation of ω3 HUFA by thecombination culture with Euglena gracilisdepartmental bulletin pape
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
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A biomarker-directed phase 2 trial of SY-1425, a selective retinoic acid receptor alpha agonist, in adult patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)
No full textTPS7071
Background: SY-1425 (tamibarotene) is an orally available, synthetic retinoid approved in Japan for the treatment of relapsed/refractory (R/R) APL. SY-1425 is a more potent and selective retinoic acid receptor alpha (RARα) agonist with improved pharmacologic properties compared to all-trans retinoic acid (ATRA) including increased half-life and lack of metabolism by CYP26A1 resulting in extended relative exposures. SY-1425 binding to RARα relieves pathogenic repression of myeloid differentiation. Super-enhancers associated with RARA and upregulation of RARA expression correlate with increased sensitivity to SY-1425 in vitro and predict for response to SY-1425 with induced differentiation and reduced proliferation in RARA-high PDX AML models, but not in RARA-low models. SY-1425 also induces the RARα target gene DHRS3 in RARA-high AML cell lines. This study is designed to demonstrate pharmacodynamic (PD) and clinical effects of SY-1425 in non-APL AML and MDS patients (pts) positive for the RARA super-enhancer associated biomarker or exploratory RARA pathway biomarker, IRF8. Methods: This study is enrolling pts with R/R AML, R/R higher-risk MDS, newly-diagnosed AML ≥60 yrs unlikely to respond to or tolerate standard therapy, and transfusion dependent lower-risk MDS pts without del 5q who are unlikely to respond to or have failed ESAs. Pts must be biomarker positive based on centralized testing of tumor cells from blood. All pts receive SY-1425 at 6 mg/m
2
/day PO with continuous twice daily dosing. Primary objectives are to characterize the activity of SY-1425 by ORR in AML and higher-risk MDS pts or transfusion independence in lower-risk MDS pts. Secondary objectives include event-free and relapse-free survival, duration of response, overall survival, hematologic improvement and safety. PD evaluation includes induction of DHRS3 and expression of myeloid differentiation markers. Target enrollment is 80 pts. This trial opened in September 2016. Through a protocol amendment, SY-1425 treatment in combination with azacitidine will also be evaluated. ClinicalTrials.gov identifier: NCT02807558
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